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34

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1550	Thiamphenicol 甲砜霉素,Dextrosulphenidol,Thiophenicol	Antibacterial; Antibiotic	Microbiology/Virology
	Thiamphenicol (Dextrosulphenidol) 是 Chloramphenicol 的甲基磺酰基衍生物，是一种广谱抗菌类抗生素。它与 50S 核糖体亚基结合，抑制蛋白质合成并具有抑菌作用，特别针对革兰氏阴性，革兰氏阳性需氧和厌氧菌。
T64767	(23S,50S)-50-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-23-(tert-butoxycarbonyl)-2,2-dimethyl-4,21,26,35,44-pentaoxo-3,30,33,39,42-pentaoxa-22,27,36,45-tetraazahenpentacontan-51-oic acid
	(23S,50S)-50-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-23-(tert-butoxycarbonyl)-2,2-dimethyl-4,21,26,35,44-pentaoxo-3,30,33,39,42-pentaoxa-22,27,36,45-tetraazahenpentacontan-51-oic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64767。
T6715	Valnemulin hydrochloride 盐酸沃尼妙林,Valnemulin HCl	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Valnemulin hydrochloride (Valnemulin HCl) 是截短侧耳素抗生素，与 50s 核糖体亚基中的肽基转移酶结合来抑制细菌中的蛋白质合成。
T1747	Tedizolid TR 700,特地唑胺,DA-7157,泰地唑利,Torezolid	MAO; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; Neuroscience
	Tedizolid (DA-7157)是一种新型恶唑烷酮类抗生素，可与核糖体50S 亚基的23S 核糖体 RNA 结合抑制细菌的蛋白质合成。
T3265	Azathramycin Desmethyl Azithromycin,阿奇霉素 A,6-Demethylazithromycin,去甲基阿奇霉素,Azaerythromycin A,Azaerythromycin	Antibacterial; Antibiotic	Microbiology/Virology
	Azathramycin (Desmethyl Azithromycin) 是一种可靶向核糖体的抗生素。
T9845	Thrombin inhibitor 5
	Thrombin inhibitor 5 (compound 385) 是一种凝血酶抑制剂，IC50范围为 0.1 μM~1 μM，可用于静脉血栓栓塞的研究。
T6448	Clindamycin hydrochloride 盐酸克林霉素,Sobelin HCl,Cleocin,Clindamycin HCl,Clinimycin HCl	Antibacterial; Antibiotic	Microbiology/Virology
	Clindamycin hydrochloride (Clinimycin HCl) 是一种半合成的林可胺类抗生素，作用于50S ribosomal 抑制蛋白质合成。
T1557	Acetylspiramycin Spiramycin II,Foromacidin B,乙酰螺旋霉素,ASPM,Spiramycin B	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Acetylspiramycin (Spiramycin B) 是口服大环内酯抗生素，由多种链霉菌产生，是螺旋霉素的乙酰化衍生物。它是对革兰氏阳性菌有效的抗菌试剂。它也是一种抗原虫剂，有效抵抗寄生虫感染。
T2331	Solithromycin 索利霉素,OP-1068,CEM-101	Antibacterial; Antibiotic	Microbiology/Virology
	Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。
T11836	Lefamulin acetate BC-3781 acetate,醋酸来法莫林	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Lefamulin acetate (BC-3781 acetate) 是具有口服活性的抗生素。它是用于人体细菌感染的全身研究的半合成截短侧耳素。它与 50S 细菌核糖体的肽基转移酶peptidyl transferase 中心结合抑制蛋白质合成，并阻止了转移RNA 与肽转移的结合。
T22297	Clindamycin hydrochloride monohydrate Clindamycin alcoholate	Antibiotic	Microbiology/Virology
	Clindamycin hydrochloride monohydrate（Clindamycin alcoholate）是一种口服蛋白质合成抑制剂，具有在金黄色葡萄球菌中以亚抑制浓度(sub-MICs)抑制毒力因子表达的能力。其抗性来源于50S核糖体亚基（23S rRNA）的抗生素结合位点通过酶促甲基化。此外，Clindamycin hydrochloride monohydrate能显著减少杀白细胞毒素（PVL）、毒性休克-葡萄球菌毒素（TSST-1）或α-溶血素（Hla）的产生。
T3125	Amikacin sulfate Amikacin Sulfate Salt,阿米卡霉素硫酸,硫酸阿米卡星	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Amikacin sulfate 是一种氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它抑制大多数革兰氏阴性细菌，还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
T8404	Kasugamycin hydrochloride hydrate Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate)) 是一种能结合 30s 和 70s 核糖体，但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸破坏 tRNA 结合并抑制典型翻译起始。
T6382	Amikacin disulfate 硫酸阿米卡星,Pierami,阿米卡星硫酸盐,BAY-416651 sulfate,BB-K8,Amikacin sulfate	Antibacterial; Antibiotic	Microbiology/Virology
	Amikacin disulfate (BAY-416651 sulfate) 是氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它对大多数革兰氏阴性细菌都有效。它还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
T22707	Dalfopristin (mesylate) (112362-50-2 free base) Dalfopristin (mesylate)	Others	Others
	Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Strep
T71199	CGP7040
	CGP7040 is a rifamycin analogue, is a protein 50S ribosomal subunit inhibitor that was being developed by Novartis.
T4543	Telithromycin HMR3647,泰利霉素,Ketek,RU66647	Antibacterial; Antibiotic	Microbiology/Virology
	Telithromycin (HMR3647) 是一种社区获得性肺炎抗生素。
T71810	Thiamphenicol palmitate
	Thiamphenicol palmitate is a Prodrug of Thiamphenicol, inhibiting the 50S subunit of the bacterial ribosome and protein translation.
T71449	Capreomycin free base
	Capreomycin is a polypeptide antibiotic originally isolated from S. capreolus. It is active against M. tuberculosis (MIC = 10 µg/ml). Capreomycin binds to both the 30S and 50S ribosomal subunits, inhibiting protein synthesis.
T60518	Tolmetin sodium
	Tolmetin sodium 是非甾体抗炎药，是口服有效的COX 抑制剂，对人 COX-1 的IC50值为 0.35 μM 和对人 COX-2 的IC50值为0.82 μM。
T21501	5,15-DPP
	5,15-Diphenylporphyrin (5,15-DPP) 是一种选择性STAT3-SH2拮抗剂，其对于STAT3 和 STAT1 的IC50值分别为 0.28 μM 和 10 μM。
T75755	Histatin 5 TFA
	Histatin 5 TFA 抑制宿主基质金属蛋白酶MMP-2和MMP-9活性，IC50s 分别为 0.57 和 0.25 μM。
T40676	Erythromycin A dihydrate
	Erythromycin dihyrate dihydrate is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin dihyrate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid.
T62047	pan-HER-IN-1
	pan-HER-IN-1 (Compound C5) 是不可逆的、口服有效的广谱HER 抑制剂。pan-HER-IN-1抑制EGFR、HER4、EGFRT790M/L858R 和HER2的活性，IC50分别为 0.38、1.6、2.2 和 3.5 nM。pan-HER-IN-1可以诱导细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T31671	Erythrityl Tetranitrate Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle
	Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin. Like many nitrate esters, ETN acts as a vasodilator, and was the active ingredient in the original "sustained release" tablets, made in the early 50s. Ingesting ETN or prolonged skin contact can lead to absorption and what is known as a "nitro headache".
T61754	TMX-4116
	TMX-4116为酪蛋白激酶1α (CK1α) 降解剂，具有显著的选择性，尤其是在MOLT4、Jurkat 和 MM.1S 细胞系中，其对CK1α的降解活性强，DC50值低于200 nM。因此，TMX-4116被用于多发性骨髓瘤相关研究。
T37433	Erythromycin lactobionate
	Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.[1] It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l).[2] Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications.[3],[4] Erythromyc...
T36706	Bottromycin A2
	Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively. 1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Go...
T60471	Lanicemine dihydrochloride
	Lanicemine (AZD6765) dihydrochloride 是NMDA 通道的低捕获拮抗剂，Ki 值为 0.56-2.1 μM，在CHO 和爪蟾卵母细胞的IC50分别为 4-7 μM 和 6.4 μM。Lanicemine (AZD6765) dihydrochloride 具有持续的抗抑郁功效。
T37432	Erythromycin A N-oxide
	Erythromycin A N-oxide is a potential impurity found in commercial preparations of erythromycin. Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can af...
T62046	HDAC6-IN-5
	HDAC6-IN-5 (化合物 11b) 是有效的、血脑屏障通透性的 HDAC6抑制剂(IC50= 0.025 μM)。HDAC6-IN-5 抑制 AChE 活性和 Aβ1-42自聚集和，IC50分别为 0.88 和 1.1 μM。HDAC6-IN-5 能够促进神经突起生长，且无明显神经毒性。
T60658	hMAO-B/MB-COMT-IN-2
	hMAO-B/MB-COMT-IN-2 是MAO-B/MB-COMT 的双重抑制剂，对hMAO-B 和MB-COMT 的IC50值分别为 4.27 μM 和 2.69 μM。hMAO-B/MB-COMT-IN-2 保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD) 等的研究。
T6383	Amikacin hydrate 阿米卡星水合物,BAY416651 hydrate	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Amikacin hydrate (BAY416651 hydrate) 是氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
T73822	GGTI-286 TFA
	GGTI-286 TFA 是一种高效的细胞通透性 GGTase I 抑制剂，(IC50为 2 μM。在 NIH3T3 细胞中，GGTI-286 TFA 对 Rap1A 香叶香叶基化的抑制作用高于 H-Ras 的法尼化作用 (IC50s=2 和 >30 μM)。GGTI-286 TFA 还能有效抑制 K-Ras4B 刺激，IC50为 1 μM。

化合物

Cat.No: T1550

Synonym: 甲砜霉素,Dextrosulphenidol,Thiophenicol

Target: Antibacterial, Antibiotic

(23S,50S)-50-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-23-(tert-butoxycarbonyl)-2,2-dimethyl-4,21,26,35,44-pentaoxo-3,30,33,39,42-pentaoxa-22,27,36,45-tetraazahenpentacontan-51-oic acid

Cat.No: T64767

Valnemulin hydrochloride

Cat.No: T6715

Synonym: 盐酸沃尼妙林,Valnemulin HCl

Target: Others, Antibacterial, Antibiotic

Cat.No: T1747

Synonym: TR 700,特地唑胺,DA-7157,泰地唑利,Torezolid

Target: MAO, Antibacterial, Antibiotic

Cat.No: T3265

Synonym: Desmethyl Azithromycin,阿奇霉素 A,6-Demethylazithromycin,去甲基阿奇霉素,Azaerythromycin A,Azaerythromycin

Target: Antibacterial, Antibiotic

Thrombin inhibitor 5

Cat.No: T9845

Clindamycin hydrochloride

Cat.No: T6448

Synonym: 盐酸克林霉素,Sobelin HCl,Cleocin,Clindamycin HCl,Clinimycin HCl

Target: Antibacterial, Antibiotic

Acetylspiramycin

Cat.No: T1557

Synonym: Spiramycin II,Foromacidin B,乙酰螺旋霉素,ASPM,Spiramycin B

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T2331

Synonym: 索利霉素,OP-1068,CEM-101

Target: Antibacterial, Antibiotic

Lefamulin acetate

Cat.No: T11836

Synonym: BC-3781 acetate,醋酸来法莫林

Target: ribosome, Antibacterial, Antibiotic

Clindamycin hydrochloride monohydrate

Cat.No: T22297

Synonym: Clindamycin alcoholate

Target: Antibiotic

Amikacin sulfate

Cat.No: T3125

Synonym: Amikacin Sulfate Salt,阿米卡霉素硫酸,硫酸阿米卡星

Target: ribosome, Antibacterial, Antibiotic

Kasugamycin hydrochloride hydrate

Cat.No: T8404

Synonym: Ksg (hydrochloride hydrate),春雷霉素盐酸盐一水合物

Target: Antibacterial, Antibiotic

Amikacin disulfate

Cat.No: T6382

Synonym: 硫酸阿米卡星,Pierami,阿米卡星硫酸盐,BAY-416651 sulfate,BB-K8,Amikacin sulfate

Target: Antibacterial, Antibiotic

Dalfopristin (mesylate) (112362-50-2 free base)

Cat.No: T22707

Synonym: Dalfopristin (mesylate)

Target: Others

Cat.No: T71199

Cat.No: T4543

Synonym: HMR3647,泰利霉素,Ketek,RU66647

Target: Antibacterial, Antibiotic

Thiamphenicol palmitate

Cat.No: T71810

Capreomycin free base

Cat.No: T71449

Tolmetin sodium

Cat.No: T60518

Cat.No: T21501

Cat.No: T75755

Erythromycin A dihydrate

Cat.No: T40676

Cat.No: T62047

Erythrityl Tetranitrate

Cat.No: T31671

Synonym: Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle

Cat.No: T61754

Erythromycin lactobionate

Cat.No: T37433

Cat.No: T36706

Lanicemine dihydrochloride

Cat.No: T60471

Erythromycin A N-oxide

Cat.No: T37432

Cat.No: T62046

hMAO-B/MB-COMT-IN-2

Cat.No: T60658

Amikacin hydrate

Cat.No: T6383

Synonym: 阿米卡星水合物,BAY416651 hydrate

Target: Others, Antibacterial, Antibiotic

Cat.No: T73822

Cat. No.	Product Name	Target	Signaling Pathways
T16552	Pleuromutilin Mutilin 14-glycolate,Drosophilin B,截短侧耳素	Antibacterial; Antibiotic	Microbiology/Virology
	Pleuromutilin (Drosophilin B) 通过与细菌的 50S 核糖体亚基结合来抑制细菌蛋白质的合成。
T1205	Chloramphenicol Chlornitromycin,Levomycetin,Chloromycetin,氯霉素	ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Chloramphenicol (Chloromycetin) 是一种广谱抗生素，有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基，对肽基转移酶有活性，抑制肽键的形成。
T1032	Erythromycin 红霉素,E-Mycin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Erythromycin (E-Mycin) 是由放线菌产生的大环内酯类抗生素。它结合细菌的 50S 核糖体亚基，通过阻断转肽和易位反应来抑制 RNA 依赖性蛋白的合成。
T1214	Ribostamycin sulfate Vistamycin sulfate,硫酸核糖霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Ribostamycin sulfate (Vistamycin sulfate) 是一种广谱抗菌剂, 在30S 和50S 核糖体亚基结合抑制细菌蛋白质合成, 还抑制蛋白二硫键异构酶分子伴侣活性, 用于药代动力学和肾毒性研究。
T2762	Kasugamycin hydrochloride Kasumin,盐酸春雷霉素	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Kasugamycin hydrochloride (Kasumin) 是一种能结合 30s 和 70s 核糖体，但不能结合 50s 亚基的抗生素。它模拟 mRNA 核苷酸以破坏 tRNA 结合并抑制经典翻译起始。
T11233	Erythromycin thiocyanate	Antibacterial	Microbiology/Virology
	Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .Erythromycin thiocyanate

天然产物

Cat.No: T16552

Synonym: Mutilin 14-glycolate,Drosophilin B,截短侧耳素

Target: Antibacterial, Antibiotic

Chloramphenicol

Cat.No: T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin,氯霉素

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Cat.No: T1032

Synonym: 红霉素,E-Mycin

Target: ribosome, Antibacterial, Antibiotic

Ribostamycin sulfate

Cat.No: T1214

Synonym: Vistamycin sulfate,硫酸核糖霉素

Target: Antibacterial, Antibiotic

Kasugamycin hydrochloride

Cat.No: T2762

Synonym: Kasumin,盐酸春雷霉素

Target: Antibacterial, Antibiotic, Antifungal

Erythromycin thiocyanate

Cat.No: T11233

Target: Antibacterial

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