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Search Results for " 5-ht6 "

53

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T61807	5-HT6/7 antagonist 1	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT6/7 antagonist 1是一种 5-HT6/7/2A 和 D2 受体双重拮抗剂，可用于研究痴呆和阿尔兹海默症。
T3183	SAX-187 WAY 181187,WAY181187	5-HT Receptor	GPCR/G Protein; Neuroscience
	SAX-187 (SAX-187) 是一种有效的选择性5-HT6受体激动剂，Ki 为 2.2 nM，EC50为 6.6 nM。它介导 5-HT6 受体依赖性信号通路，可作为特异性激动剂。
T8720	PRX-07034 hydrochloride PRX-07034	5-HT Receptor	GPCR/G Protein; Neuroscience
	PRX-07034 hydrochloride 是一种有效的高度选择性5-HT6受体拮抗剂，Ki 为 4-8 nM，IC50为 19 nM，可用于增强工作记忆和认知灵活性的研究。
T30798	Cerlapirdine PF05212365,P -05212365,SAM-531,SAM531,PF-05212365,SAM 531,WAY-262,531	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cerlapirdine (PF-05212365) 是一种选择性 5-羟色胺 6 (5-HT6) 受体的完全拮抗剂，用于治疗与阿尔茨海默病和精神分裂症相关的认知障碍。
T79325	5-HT6 agonist 1	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT6 agonist 1 (Compound 19)为一种5-HT6激动剂 (Ki: 5 nM)，展现出抗抑郁样特性并能改善认知缺陷，同时能抑制血小板聚集，具备高代谢稳定性。
T61837	5-HT6/5-HT2AR antagonist-1
	5-HT6/5-HT2AR antagonist-1 is a powerful and effective compound that acts as a dual antagonist for both the 5-HT6 and 5-HT2A receptors. It exhibits high potency with K i values of 11 nM and 39 nM for the respective receptors [1].
T61207	5-HT6/5-HT2A receptor ligand-1
	5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in neurological and psychiatric disorders [1].
T61220	5-HT6/5-HT2A receptor ligand-2
	5-HT6/5-HT2A receptor ligand-2 (化合物 42) 是一种可透过血脑屏障的5-HT6/5-HT2A 的双拮抗剂 ,Ki 值分别为 25 nM 和 32 nM。5-HT6/5-HT2A receptor ligand-2 具有促认知特性。
T13007	ST1936 oxalate	5-HT Receptor	GPCR/G Protein; Neuroscience
	ST1936 oxalate 是一种 5-HT6 受体的选择性纳摩尔亲和激动剂，对人5-HT6、5-HT7和 5-HT2B 受体的 Ki 值分别为 13、168 和 245 nM。
T4118	SB 271046 hydrochloride SB 271046A	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 271046 hydrochloride (SB 271046A) 是高效、选择性和具有口服活性的5-HT6受体拮抗剂，对大鼠、猪和人的pKi 分别为 9.02、8.55 和 8.81。它增加额叶皮层中的细胞外天冬氨酸和谷氨酸并表现出抗惊厥活性，EC50为 0.16 μM。它对 5-HT6 受体、结合位点和离子通道的选择性超过 200 倍。
T11948	Masupirdine free base Masupirdine,SUVN-502 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	Masupirdine free base（SUVN-502 free base）是一种可口服且可穿过血脑屏障的 5-HT6 受体拮抗剂，对人类 5-HT6 受体的 Ki 值为 2.04 nM。Masupirdine free base 具有高效性和选择性且对多种靶点都具有抑制作用。Masupirdine free base 可用于研究像阿尔茨海默病类的神经系统疾病。
T10053	5HT6-ligand-1	5-HT Receptor	GPCR/G Protein; Neuroscience
	5HT6-ligand-1 是一种具有口服活性的 5-HT6 受体配体 (Ki = 1.43 nM)。
T1774	Intepirdine RVT-101,SB 742457,GSK-742457	5-HT Receptor	GPCR/G Protein; Neuroscience
	Intepirdine (GSK-742457) 是5-HT6受体拮抗剂，pKi 为9.63，用于研究阿尔茨海默病治疗的试验。
T7103	idalopirdine Lu AE58054	5-HT Receptor	GPCR/G Protein; Neuroscience
	Idalopirdine (Lu AE58054) 是一种选择性的5-HT6 受体拮抗剂，Ki 为 0.83 nM。
T11949	Masupirdine mesylate SUVN-502 mesylate,SVN-502 mesylate	5-HT Receptor	GPCR/G Protein; Neuroscience
	Masupirdine mesylate (SUVN-502 mesylate) 是一种具有选择性且可穿越血脑屏障的 5-HT6 受体拮抗剂。Masupirdine mesylate 可用于研究阿尔茨海默病和痴呆等神经系统疾病。
T11183	EMDT	5-HT Receptor	GPCR/G Protein; Neuroscience
	EMDT是一种选择性 5-HT6 激动剂，具有抗抑郁作用。
T23396	ST1936 ST 1936 oxalate	5-HT Receptor	GPCR/G Protein; Neuroscience
	ST1936 (ST 1936 oxalate) 是一种具有选择性和高效性的 5-HT6 受体激动剂，抑制人 5-HT6、5-HT7 和 5-HT2B 受体，通过完全激活克隆的人 5-HT6 受体来刺激 cAMP、Ca2+、ERK1/2 和 Fyn 激酶。
T26085	rilapine Rilapinum
	Rilapine is an atypical antipsychotic with high affinity for the 5-HT6 receptor.
T23318L	SB 258585	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 258585 是一种选择性 5-HT6受体拮抗剂。SB 258585 对人重组5-HT6受体的细胞系中的单个受体群体亲和力很高。SB 258585 可用于标记重组和天然5-HT6受体，可用于检测认知增强和抗精神病活性。
T12262L1	NPS ALX Compound 4a hydrochloride(1:1)	5-HT Receptor	GPCR/G Protein; Neuroscience
	NPS ALX Compound 4a hydrochloride(1:1)是一种有效、选择性的 5-羟色胺受体 6 (5-HT6) 受体拮抗剂，IC50 值为 7.2 nM，且具有高亲和力，Ki 值为 0.2 nM。
T22936	Idalopirdine Hydrochloride Lu AE58054盐酸盐,Lu AE58054 Hydrochloride,Idalopirdine HCl	5-HT Receptor	GPCR/G Protein; Neuroscience
	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) 是一种选择性的5-HT6 受体拮抗剂，Ki 为 0.83 nM。
T31592	E6801 E 6801,E-6801	5-HT Receptor	GPCR/G Protein; Neuroscience
	E6801是一种新型选择性5-HT6受体激动剂，具有广泛的生物活性。E6801可用于研究痴呆、帕金森病、抑郁症、肥胖症癫痫，焦虑等多种疾病。
T50090	3-(2-phenylethynyl)pyridine	Others	Others
	3-(2-phenylethynyl)pyridine 是一种吡啶衍生物，是人体中各种受体的配体，包括多巴胺 D2受体、sigma-1受体和5-HT6受体，已被研究用于治疗各种神经疾病，包括精神分裂症、抑郁症和阿尔茨海默病。
T12262	NPS ALX Compound 4a	5-HT Receptor	GPCR/G Protein; Neuroscience
	NPS ALX Compound 4a is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T12262L	NPS ALX Compound 4a dihydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T12843	SB-399885 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
T23029	MS 245 oxalate	Others	Others
	MS 245 oxalate is a 5-HT6 antagonist.
T23318	SB 258585 hydrochloride	Others	Others
	SB 258585 hydrochloride is a 5-HT6 receptor antagonist.
T23527	WAY208466 dihydrochloride WAY 208466 dihydrochloride	Others	Others
	5-HT6 agonist
T62082	FPPQ
	FPPQ 是一种 5-HT3 和 5-HT6 受体的双重拮抗剂，他们的 Ki 值分别为 0.9 nM 和 3 nM，表现出抗精神病和促认知活性。
T23350	SGS518 oxalate SGS 518 oxalate	Others	Others
	SGS518 oxalate is a 5-HT6 antagonist.
T24716	Ro 04-6790 dihydrochloride
	Ro 04-6790 dihydrochloride is an effective and selective antagonist of the serotonin 5-HT6 receptor.
T23240	Ro 04-6790	Others	Others
	Ro 04-6790 is a 5-HT6 receptor antagonist.
T22763	EMD 386088 hydrochloride	Others	Others
	EMD 386088 hydrochloride is a 5-HT6 receptor agonist.
T28768	SGS-518 SGS518,LY-483518,LY 483518,LY483518
	SGS-518 is a selective antagonist of the 5-HT6 receptor.
T83289	5-HT6R antagonist 2
	5-HT6R antagonist 2 (compound 29)为高选择性5-HT6受体拮抗剂，具备潜在的中枢神经系统(CNS)治疗应用。
T28594	Ro 63-0563 Ro-63-0563,Ro63-0563
	Ro 63-0563 is a potent, 5-HT6 receptors selective antagonist.
T30230	AVN-211 CD-008-0173,AVN 211
	AVN-211 (CD-008-0173) is a novel and highly selective 5-HT6 receptor small molecule antagonist for the treatment of Alzheimer's disease.
T23214	R 1485 dihydrochloride	Others	Others
	5-HT6 antagonist,selective and high affinity
T26691	AVN-322 AVN 322
	AVN-322 is a 5-HT6 receptor antagonist. 5-HT6R antagonists improves cognition in animal models of cognitive impairment.
T4375	Methiothepin maleate Metitepine,甲替平	5-HT Receptor	GPCR/G Protein; Neuroscience
	Methiothepin maleate (Metitepine) 是一种 5-HT1、5-HT6、5-HT7 血清素受体拮抗剂，可阻断血清素自身受体。
T27455	GSK-215083 GSK215083
	GSK-215083 is a PET radioligand for the 5-HT6 receptor. GSK 215083 is a quinoline based compounds and acts by antagonising the 5-HT6 receptor. GSK-215083 binds to receptors 5-hydroxytrypamine-6 (5HT6) in the striatum and 5-hydroxytryptamine-2A (5HT2A) in
T28689	SB357134 SB-357134,SB 357134
	SB357134 is a potent, selective and orally active antagonist of 5-HT6 receptor and shows nootropic effects in animal studies.
T68353	BVT-74316
	BVT-74316 is an orally administered antagonist of the serotonin 6 receptor (5-HT6) being developed by Proximagen
T71593	AVN-101 free base
	AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
T63038	WAY-181187 oxalate
	WAY-181187 (SAX-187) oxalate 是一种选择性的、有效的 5-HT6 受体的激动剂 (Ki: 2.2 nM; EC50: 6.6 nM)。WAY-181187 oxalate 是一种特异性激动剂，介导 5-HT6 受体依赖性信号通路（如 cAMP，Fyn 和 ERK1/2 激酶）。
T22044	BGC 20-761
	BGC20-761 是一种选择性的5-HT6和多巴胺受体 (dopamine receptor) 拮抗剂，对人 5-HT6，5-HT2A，D2 受体的Ki 值分别为 20，69，和 140 nM。BGC20-761 可增强长期记忆。BGC20-761 具有作为抗精神病药物的潜在效用。
T78648	MAO-B-IN-3	Monoamine Oxidase	Neuroscience
	MAO-B-IN-3是一种选择性MAO-B抑制剂，具有可逆性，IC50为96 nM。该化合物还可与5-HT6R结合，Ki值为696 nM，适用于阿尔茨海默病研究。
T1951	Asenapine Maleate Org 5222 maleate,Org 5222,马来酸阿塞那平,阿塞那平马来酸盐	5-HT Receptor	GPCR/G Protein; Neuroscience
	Asenapine Maleate (Org 5222 maleate) 是5-HT 和D2的拮抗剂，Ki 值分别为 0.03-4.0 nM, 1.3 nM。它也是抗精神病药物，用于治疗与双相 1 型障碍相关的精神分裂症和躁狂或混合发作。
T69104	SAX-187 hydrochloride
	SAX-187 hydrochloride is a potent and selective 5-HT6 receptor agonist. SAX-187 hydrochloride possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (SAX-187 hydrochloride: EC50=6.6 nM, Emax=93%). In the rat frontal cortex, acute administration of SAX-187 hydrochloride (3-30 mg/kg, subcutaneous (s.c.)) significantly increased extracellular GABA concentrations without altering the levels of glutamate or norepinephrine.

化合物

5-HT6/7 antagonist 1

Cat.No: T61807

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T3183

Synonym: WAY 181187,WAY181187

Target: 5-HT Receptor

PRX-07034 hydrochloride

Cat.No: T8720

Synonym: PRX-07034

Target: 5-HT Receptor

Cat.No: T30798

Synonym: PF05212365,P -05212365,SAM-531,SAM531,PF-05212365,SAM 531,WAY-262,531

Target: 5-HT Receptor

5-HT6 agonist 1

Cat.No: T79325

Target: 5-HT Receptor

5-HT6/5-HT2AR antagonist-1

Cat.No: T61837

5-HT6/5-HT2A receptor ligand-1

Cat.No: T61207

5-HT6/5-HT2A receptor ligand-2

Cat.No: T61220

Cat.No: T13007

Target: 5-HT Receptor

SB 271046 hydrochloride

Cat.No: T4118

Synonym: SB 271046A

Target: 5-HT Receptor

Masupirdine free base

Cat.No: T11948

Synonym: Masupirdine,SUVN-502 free base

Target: 5-HT Receptor

Cat.No: T10053

Target: 5-HT Receptor

Cat.No: T1774

Synonym: RVT-101,SB 742457,GSK-742457

Target: 5-HT Receptor

Cat.No: T7103

Synonym: Lu AE58054

Target: 5-HT Receptor

Masupirdine mesylate

Cat.No: T11949

Synonym: SUVN-502 mesylate,SVN-502 mesylate

Target: 5-HT Receptor

Cat.No: T11183

Target: 5-HT Receptor

Cat.No: T23396

Synonym: ST 1936 oxalate

Target: 5-HT Receptor

Cat.No: T26085

Synonym: Rilapinum

Cat.No: T23318L

Target: 5-HT Receptor

NPS ALX Compound 4a hydrochloride(1:1)

Cat.No: T12262L1

Target: 5-HT Receptor

Idalopirdine Hydrochloride

Cat.No: T22936

Synonym: Lu AE58054盐酸盐,Lu AE58054 Hydrochloride,Idalopirdine HCl

Target: 5-HT Receptor

Cat.No: T31592

Synonym: E 6801,E-6801

Target: 5-HT Receptor

3-(2-phenylethynyl)pyridine

Cat.No: T50090

Target: Others

NPS ALX Compound 4a

Cat.No: T12262

Target: 5-HT Receptor

NPS ALX Compound 4a dihydrochloride

Cat.No: T12262L

Target: 5-HT Receptor

SB-399885 hydrochloride

Cat.No: T12843

Target: 5-HT Receptor

Cat.No: T23029

Target: Others

SB 258585 hydrochloride

Cat.No: T23318

Target: Others

WAY208466 dihydrochloride

Cat.No: T23527

Synonym: WAY 208466 dihydrochloride

Target: Others

Cat.No: T62082

Cat.No: T23350

Synonym: SGS 518 oxalate

Target: Others

Ro 04-6790 dihydrochloride

Cat.No: T24716

Cat.No: T23240

Target: Others

EMD 386088 hydrochloride

Cat.No: T22763

Target: Others

Cat.No: T28768

Synonym: SGS518,LY-483518,LY 483518,LY483518

5-HT6R antagonist 2

Cat.No: T83289

Cat.No: T28594

Synonym: Ro-63-0563,Ro63-0563

Cat.No: T30230

Synonym: CD-008-0173,AVN 211

R 1485 dihydrochloride

Cat.No: T23214

Target: Others

Cat.No: T26691

Synonym: AVN 322

Methiothepin maleate

Cat.No: T4375

Synonym: Metitepine,甲替平

Target: 5-HT Receptor

Cat.No: T27455

Synonym: GSK215083

Cat.No: T28689

Synonym: SB-357134,SB 357134

Cat.No: T68353

AVN-101 free base

Cat.No: T71593

WAY-181187 oxalate

Cat.No: T63038

Cat.No: T22044

Cat.No: T78648

Target: Monoamine Oxidase

Asenapine Maleate

Cat.No: T1951

Synonym: Org 5222 maleate,Org 5222,马来酸阿塞那平,阿塞那平马来酸盐

Target: 5-HT Receptor

SAX-187 hydrochloride

Cat.No: T69104

Cat. No.	Product Name	Target	Signaling Pathways
T21499	Dimebolin Latrepirdine,Dimebon,Dimebone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Dimebolin (Latrepirdine) 是一种 5-HT6 拮抗剂。
T3369	Nuciferine (-)-Nuciferine,VLT 049,荷叶碱,Sanjoinine E	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Nuciferine ((-)-Nuciferine) 是一种在埃及蓝睡莲和水芙蓉中发现的生物碱，是5-HT2A、5-HT2B 和5-HT2C 拮抗剂，IC50分别为 478 nM、1 μM 和 131 nM。它也是5-HT7的反向激动剂，IC50为 150 nM。

天然产物

Cat.No: T21499

Synonym: Latrepirdine,Dimebon,Dimebone

Target: 5-HT Receptor

Cat.No: T3369

Synonym: (-)-Nuciferine,VLT 049,荷叶碱,Sanjoinine E

Target: Dopamine Receptor, 5-HT Receptor

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