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Search Results for " 11β-hsd1 "

33

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10160	11β-HSD1-IN-1	Dehydrogenase	Metabolism
	11β-HSD1-IN-1是1β 羟类固醇脱氢酶Ⅰ型（11β-HSD1，IC50:52nM）的抑制剂，用于治疗疼痛。
T64321	Octyl-beta-D-glucopyranoside Octyl glucoside,11β-HSD1-IN-11	Others	Others
	Octyl-beta-D-glucopyranoside (11β-HSD1-IN-11) 是一种非离子洗涤剂，广泛应用于生物技术，生化应用，膜蛋白的增溶和结晶的研究中。
T72814	11β-HSD1-IN-12	Dehydrogenase	Metabolism
	11β-HSD1-IN-12 是一种11β-HSD1抑制剂。11β-HSD1 可从非活性形式再生活性糖皮质激素，在调节细胞内糖皮质激素浓度方面很重要。11β-HSD1-IN-12 可用于肥胖和代谢综合征的研究。
T67903	11β-HSD1 inibitor 17	Dehydrogenase	Metabolism
	11β-HSD1 inibitor 17 是11β-羟基类固醇脱氢酶（11β-HSD1）抑制剂。
T72022	11β-HSD1 inibitor 19
	11β-HSD1 inibitor 19 对 hHSD1 和 mHSD1 显示抑制活性，IC50 为 16 nM 和 10 nM。
T60149	11β-HSD1-IN-11	Dehydrogenase	Metabolism
	11β-HSD1-IN-11 是一种有效的、具有竞争性的 11- β-羟基类固醇脱氢酶1 (11β-HSD1)抑制剂，对大鼠和人的 11β-HSD1具有抑制作用，IC50 分别为 0.34 μM 和 0.13 μM。11β-HSD1- in -11是一种作为的化合物。11β-HSD1-IN-11是一种参与调节各种生理过程的激素，例如代谢、炎症和应激反应。11β-HSD1-IN-11是治疗代谢紊乱、肥胖和某些炎症状况的潜在化合物。
T65743	11β-HSD1-IN-8
	11β-HSD1-IN-8 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65743，CAS号为 386704-15-0。
T72911	11β-HSD1-IN-9
	11β-HSD1-IN-9 (化合物 c4a) 是有效对人源和鼠源11β-HSD1的抑制剂，其 IC50 值分别为 0.48 µM 和 1.3 µM。此化合物与大鼠11β-HSD1之间存在竞争性相互作用，适用于研究肥胖、高血糖和认知障碍。
T72859	11β-HSD1-IN-10
	11β-HSD1-IN-10 (化合物 c3a) 是一种针对11β-HSD1的有效抑制剂，具有对人IC50值为1.8 µM。可应用于肥胖、高血糖和认知障碍研究。
T61593	11β-HSD1-IN-6
	11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs). These enzymes are responsible for catalyzing the conversion of the active glucocorticoids, corticosterone or cortisol, to their respective inactive forms, 11-dehydrocorticosterone (11-DHC) and cortisone. The compound 11β-HSD1-IN-6 specifically targets and inhibits 11β-HSD-1, effectively modulating the interconversion of these glucocorticoids. [1]
T67622	11β-HSD1-IN-7
	11β-HSD1-IN-7 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67622，CAS号为 728-86-9。
T3542	BVT-14225 BVT 14225	Dehydrogenase	Metabolism
	BVT-14225 是一种选择性的11β羟基类固醇脱氢酶1型(11β-HSD1)抑制剂(IC50:52 nM)。
T14388	AZD 4017	Dehydrogenase	Metabolism
	AZD 4017 是高效的、选择性的11β-HSD1抑制剂，IC50为 7 nM。
T2057	BVT 2733	Dehydrogenase	Metabolism
	BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病具有潜在的研究价值。
T63569	HSD-016
	HSD-016 是选择性的、有效的、口服具有活力的 1 型 11β-羟类固醇脱氢酶（11β-HSD1）抑制剂，能够作用于人 11β-HSD1 (IC50: 11 nM)、小鼠 11β-HSD1 (IC50: 1 nM)、大鼠 11β-HSD1 (IC50: 8 nM)。HSD-016 能够用于研究 2 型糖尿病。
T77606	WAY-311610	Dehydrogenase	Metabolism
	WAY-311610是一种11β-羟基类固醇脱氢酶HSD11B1抑制剂，抑制11β-HSD1酶，IC = 0.34μM。可用于研究神经性疼痛、炎症性疼痛和枕神经痛。
T64349	Necroptosis-IN-3 Cyclohexanecarboxamide, N-(2-thienylmethyl)-	Necroptosis	Apoptosis
	Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-)(Compound 69) 是一种坏死性凋亡 (necroptosis) 抑制剂，抑制 TNF-α 诱导的坏死性凋亡。Necroptosis-IN-3(Compound 69) 也抑制 11β-HSD1。
T14383	AZD8329	Dehydrogenase	Metabolism
	AZD8329 是一种可选择且高效的人重组11β-HSD1 和离体人脂肪细胞11ß-HSD1 的抑制剂，是大鼠11β-HSD1 (IC50 - 89nM)和狗重组11β-HSD1的抑制剂。AZD8329在体外实验中对11β-HSD1的亲和力高于人重组11β-HSD2和17β- hsd1和17β-HSD3酶。AZD8329具有降低脂肪组织和肝脏样品中11β-HSD1的活性。
T16510	PF-915275	Dehydrogenase	Metabolism
	PF-915275 是口服有效的人 11β-羟基类固醇脱氢酶1型选择性抑制剂，Ki 为 2.3 nM，在 HEK293 细胞中的EC50为 15 nM 。它对人和猴原代肝细胞中可的松向皮质醇的转化具有剂量依赖性，EC50分别为 20 nM 和 100 nM。
T26794	BI-135585
	BI-135585 is a potent and selective inhibitor of 11β-HSD1.
T12663	(Rac)-BMS-816336	Dehydrogenase	Metabolism
	(Rac)-BMS-816336 (Compound 6n) 是 BMS-816336 的外消旋体。(Rac)-BMS-816336 是人和小鼠 11β-羟类固醇脱氢酶 1 型 (11β-HSD1) 的有效抑制剂，其 IC50分别为 10 nM 和 68 nM，并具有良好的代谢稳定性。
T0293	Metyrapone 美替拉酮,甲吡酮,NSC-25265,Su-4885	Others; P450; Dehydrogenase; Autophagy	Autophagy; Metabolism; Others
	Metyrapone (NSC-25265) 是 STEROID 11-BETA-MONOOXYGENASE 酶抑制剂。它被用作库欣综合征诊断中下丘脑-垂体反馈机制的测试。
T23845	BVT-116429
	BVT-116429 is an inhibitor of 11β-HSD1.
T60203	INCB13739
	INCB13739是一种具有口服活性、高效、选择性及组织特异性的11β-HSD1抑制剂，对11β-HSD1酶的IC50为3.2 nM，对11β-HSD1 PBMC的IC50为1.1 nM。适用于2型糖尿病(T2DM)和肥胖的研究。
T26617	AMG-221 AMG221
	AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice.
T28796	SKI2852 SK I2852,SKI-2852
	SKI2852 is a highly Potent, selective, and orally bioavailable inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM.
T26724	AZD-9164 bromide AZD9164,AZD-9164,AZD 9164
	AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fed blood glucose and insulin levels
T71243	ASP3662
	ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11β-HSD1. The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neuropathic and dysfunctional pain, as observed in fibromyalgia. ASP3662 inhibited human, mouse and rat 11β-HSD1 but not human 11β-HSD2, in vitro. ASP3662 inhibited in vitro conversion of glucocorticoid from its inactive to active form in extracts of rat brain and spinal cord.
T72249	BMS-823778 hydrochloride
	BMS-823778 hydrochloride为一种高效、选择性的口服11β-HSD1抑制剂，其对人11β-HSD1的IC50值为2.3 nM。
T80817	WAY-328127
	WAY-328127是一种活性分子，适用于生化反应研究。
T70509	INU-101
	INU-101 is an 11β-HSD1 inhibitor. In KKAy mice, ob/ob mice, and ZDF rats, oral administration of INU-101 led to enhanced insulin sensitivity and the lowering of the fasting level of glucose in the blood. INU-101 therefore shows promise as a potential treatment for type 2 diabetes and metabolic syndrome.
T70763	KR-67607
	KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 rever...
T26528	ABT-384
	ABT-384 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.

化合物

11β-HSD1-IN-1

Cat.No: T10160

Target: Dehydrogenase

Octyl-beta-D-glucopyranoside

Cat.No: T64321

Synonym: Octyl glucoside,11β-HSD1-IN-11

Target: Others

11β-HSD1-IN-12

Cat.No: T72814

Target: Dehydrogenase

11β-HSD1 inibitor 17

Cat.No: T67903

Target: Dehydrogenase

11β-HSD1 inibitor 19

Cat.No: T72022

11β-HSD1-IN-11

Cat.No: T60149

Target: Dehydrogenase

11β-HSD1-IN-8

Cat.No: T65743

11β-HSD1-IN-9

Cat.No: T72911

11β-HSD1-IN-10

Cat.No: T72859

11β-HSD1-IN-6

Cat.No: T61593

11β-HSD1-IN-7

Cat.No: T67622

Cat.No: T3542

Synonym: BVT 14225

Target: Dehydrogenase

Cat.No: T14388

Target: Dehydrogenase

Cat.No: T2057

Target: Dehydrogenase

Cat.No: T63569

Cat.No: T77606

Target: Dehydrogenase

Necroptosis-IN-3

Cat.No: T64349

Synonym: Cyclohexanecarboxamide, N-(2-thienylmethyl)-

Target: Necroptosis

Cat.No: T14383

Target: Dehydrogenase

Cat.No: T16510

Target: Dehydrogenase

Cat.No: T26794

(Rac)-BMS-816336

Cat.No: T12663

Target: Dehydrogenase

Cat.No: T0293

Synonym: 美替拉酮,甲吡酮,NSC-25265,Su-4885

Target: Others, P450, Dehydrogenase, Autophagy

Cat.No: T23845

Cat.No: T60203

Cat.No: T26617

Synonym: AMG221

Cat.No: T28796

Synonym: SK I2852,SKI-2852

AZD-9164 bromide

Cat.No: T26724

Synonym: AZD9164,AZD-9164,AZD 9164

Cat.No: T71243

BMS-823778 hydrochloride

Cat.No: T72249

Cat.No: T80817

Cat.No: T70509

Cat.No: T70763

Cat.No: T26528

Cat. No.	Product Name	Target	Signaling Pathways
T2869	Emodin Frangula emodin,大黄素	SARS-CoV; Casein Kinase; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Stem Cells
	Emodin (Frangula emodin) 是蒽醌衍生物，有抗SARS-CoV 作用。它阻断 SARS 冠状病毒刺突蛋白和血管紧张素转化酶 2 的相互作用。它抑制酪蛋白激酶 2 ，具有抗炎和抗癌作用。它可改善饮食诱导的肥胖小鼠的代谢紊乱。

天然产物

Cat.No: T2869

Synonym: Frangula emodin,大黄素

Target: SARS-CoV, Casein Kinase, Autophagy

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