首页工具

登录

搜索结果

Search Results for " (r)-isomer "

59

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T26744	BAY-598 R-isomer BAY598 R-isomer,BAY 598 R-isomer
	BAY-598 R-异构体是BAY589的R-异构体，它可用作参考化合物。它是是赖氨酸N-甲基转移酶（SMYD2）的抑制剂，对SMYD2比蛋白酶激活的受体1（PAR1）具有选择性。
T12617	(R)-CR8 trihydrochloride CR8, (R)-Isomer trihydrochloride	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) 是一种 CDK1/2/5/7/9 抑制剂，可作为分子胶降解剂，具有神经保护活性，可诱导细胞凋亡。
T11650	INCB3344 R-isomer	Others	Others
	INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.
T63166L	(S, R)-LSN 3318839 (S, R)-LSN 3318839(Isomer-2764704-18-7)	Glucagon Receptor	GPCR/G Protein

T12617L	(R)-CR8 (R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	(R)-CR8 ((R)-Isomer) 是 Roscovitine 类似物，是CDK1/2/5/7/9抑制剂。它作为一种分子胶降解剂来消耗细胞周期蛋白 K。它诱导细胞凋亡并具有神经保护作用。
T70544	MKC-963 (R-isomer)
	MKC-963 is a platelet aggregation inhibitor and autoinducer of CYP3A4.
T71236	Oxybutynin R-isomer HCl
	Oxybutynin R-isomer , also known as Aroxybutynin, is a muscarinic receptor antagonist. Aroxybutynin is the optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blo...
T6183	ISRIB (trans-isomer) ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer)是一种 PERK 的高效抑制剂，可有效逆转 eIF2α 磷酸化的作用，IC50值为 5 nM。
T33384	Midodrine (R-isomer HCl) ProAmatine,Midodrine,ST-1085,Gutron,Amatine
	Midodrine is a vasopressor/antihypertensive agent for the treatment of symptomatic postural hypotension.
T69703	BAY-6035-R-isomer
	BAY-6035 is an inhibitor of the methylation of MEKK2 peptide.
TD0058	6-TRITC 四甲基罗丹明-6-异硫氰酸（单一化合物）,R isomer [Tetramethylrhodamine-6-isothiocyanate]
	6-TRITC can bind to various antibody proteins, and the antibody does not lose its specificity of binding to certain antigens, and has a strong yellow-green fluorescence in alkaline solution.
T5517	(R)-Carisbamate	Others	Others
	(R)-Carisbamate 是 Carisbamate 的 R-异构体。 Carisbamate 是一种实验性抗惊厥药。
T26914L	(R)-AZD 9639	Others	Others
	(R)-AZD 9639 是 AZD 9639 的 R型异构体。AZD 9639 是一种新型呼吸道合胞病毒（RSV）融合抑制剂，具有抗病毒活性。
T22413	(R)-Viloxazine Hydrochloride	Others	Others
	(R)-Viloxazine Hydrochloride 是 Viloxazine 的 R 型异构体，Viloxazine 是一种选择性去甲肾上腺素再摄取抑制剂（NRI），可用作抗抑郁药。
T50052	1,2-diphenylpropan-2-amine	Others	Others
	1,2-diphenylpropan-2-amine 是Remacemide 的（S，R）-异构体单盐酸盐代谢产物。1,2-diphenylpropan-2-amine 具有抗惊厥作用。
T1021	(R)-Lansoprazole Dexlansoprazole,右旋兰索拉唑,T 168390,TAK 390,R-(+)-Lansoprazole	Proton pump	Membrane transporter/Ion channel
	(R)-Lansoprazole (T 168390) 是Lansoprazole 的R 型异构体。Lansoprazole 是口服有效的质子泵抑制剂，能抑制胃酸生成。Lansoprazole 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂)，能透过血脑屏障。
T68002L	(R)-Naroparcil 4-[4-[(5-Thio-α-D-xylopyranosyl)thio]benzoyl]benzonitrile(Isomer-120819-70-7)	Others	Others
	(R)-Naroparcil 是 Naroparcil 的异构体。 Naroparcil 是一种4-甲基伞形酮基 β-D-木糖苷类似物，与血管平滑肌细胞增殖有关，在 Wessler 淤滞模型中抑制血栓的形成。
T63898	Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-	PPAR	DNA Damage/DNA Repair; Metabolism
	Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-是一种PPARα/γ双激动剂，EC50 分别为 0.358μM 和1.21μM。Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-是Aleglitazar 的R 型异构体。
T29905	Alprenolol tartrate, (R)-
	Alprenolol tartrate, (R)-, is the R isomer of Alprenolol tartrate.
T17307	(R)-Ofloxacin DR3354,D-Ofloxacin,DR-3354,DR 3354,(R)-氧氟沙星,(R)-(+)-Ofloxacin,(+)-Ofloxacin	Others	Others
	(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections.
T12611	R 80123	Others	Others
	R 80123 is a highly selective inhibitor of phosphodiesterase,is the Z-isomer of R 79595
T21265	(R)-Amlodipine D-Amlodipine,(R)-(+)-Amlodipine,(+)-Amlodipine
	(R)-Amlodipine is the R isomer of Amlodipine, a medication used to prevent chest pain and lower blood pressure.
T13442	(R)-BAY1238097	Others	Others
	(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a selective BET inhibitor.
T70780	BW 737C89
	BW 737C89 is a highly potent dopamine D1 receptor antagonist; BW-737C is the (S)-isomer; BW-736C is the (R)-isomer.
T12621	(R)-FT671	Others	Others
	(R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective inhibitor of USP7 (IC50 of 52 nM)
T29671	Adrafinil, (R)- UNII-Z61JQF40LJ,Adrafinil (R)-,R-(+)-Adrafinil
	Adrafinil, (R)- is the R isomer of Adrafinil -- a eugeroic that was formerly used to promote alertness, attention, wakefulness, mood, and other parameters, particularly in the elderly.
T31176	Dabelotine, (R)- UNII-3NZJ1HNE7Y
	Dabelotine, (R)- 是 Dabelotine 的 R 型异构体。Dabelotine 是一种肾上腺素能受体激动剂,可用于研究痴呆症。
T26266	TH-162 L-PIA,(R)-PIA,(R)- PIA,(R)-PIA,L-2-N6-(Phenylisopropyl)adenosine
	TH-162, also known as (R)-PIA and Adenosine, N-(1-methyl-2-phenylethyl)-, (R)-, is an agonist of the A1 adenosine receptor. Affinity for adenosine receptors is approx. 100× that of the (+)-isomer.
T21234	(R)-Dihydrolipoic acid
	(R)-Dihydrolipoic acid is a R-isomer of Dihydrolipoic acid. It is optically active, but only the R-enantiomer is biochemically significant. The lipoic acid/dihydrolipoic acid pair participate in a variety of biochemical transformations.
T37227	(±)8(9)-DiHET
	Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
T17951	Fmoc-Gly-Gly-D-Phe-OtBu	Others	Others
	Fmoc-Gly-Gly-D-Phe-OtBu, an ADC cleavable linker, is utilized in the synthesis of antibody-drug conjugates. It is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu [1].
T61309	(R)-Oxybutynin
	(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3].
T72820	(R)-Casopitant (R)-GW679769
	(R)-Casopitant ((R)-GW679769) 是Casopitant 的异构体。Casopitant 是一种 NK(1)-受体拮抗剂。Casopitant 可用于化疗引起的恶心和呕吐的研究。
T72913	(R)-MLN-4760
	(R)-MLN-4760 是 MLN-4760 的活性较低的 R 型异构体，是一种ACE2抑制剂，IC50值为 8.4 μM。
T36840	(R)-Omeprazole (sodium salt)
	(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer . (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 μM).
T38031	(R)-KT109 (R)-KT109
	(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 .
T62881	(R)-BAY-899
	(R)-BAY-899 是一种 BAY-899 的 R 型异构体。其中 BAY-899 是一种选择性的、口服具有活力的促黄体生成激素受体 (LH-R) 拮抗剂，作用于 hLH (人 LH) (IC50: 185 nM) 和 rLH (大鼠 LH) (IC50: 46 nM)。
T35467	(±)18-HETE
	(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure. 18-HETE has negligible effects on ATPase activity. 18(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles.
T70430	XK469
	XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent.
T71736	AMG-628, (R)-
	AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
T73507	NS1219 (R)-SPD502
	NS1219 ((R)-SPD502) 是 NS 1209 的异构体。NS1209 是一种选择性AMPA 受体拮抗剂，具有神经保护活性。NS1209 可用于中风、神经性疼痛和癫痫的研究。
T36608	(±)8-HEPE
	(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.[1][2] Reference：[1]. Shing, T.K.M., Gibson, K.H., Wiley, J.R., et al. First total synthesis of a barnacle hatching factor 8(R)-hydroxy-eicosa-5(Z),9(E),11(Z)-pentaenoic acid. Tetrahedron Letters 35, 1067-1070 (1994).[2]. Hill, E...
T38148	(S)-KT109 (S)-KT109
	(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 .
T72663	(Rac)-Etavopivat (Rac)-FT-4202
	(Rac)-Etavopivat((Rac)-FT-4202) 是Etavopivat 异构体。Etavopivat 是一种具有口服活性的的红细胞丙酮酸激酶-R (PKR) 激活剂，可以用于镰状细胞病和其他血红蛋白疾病研究。
T71483	Streptonigrin (racemate)
	Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.
T12634	(R)-NVS-ZP7-4	Others	Others
	(R)-NVS-ZP7-4 是 NVS-ZP7-4 的 R 型异构体。 NVS-ZP7-4 是一个报道用于探测内质网锌水平影响的化学分子，是一种锌转运体 SLC39A7(ZIP7)的抑制剂，并研究 ZIP7 作为 Notch 通路中的一种新的可成药节点。
T37651	5(S),6(R)-11-trans DiHETE
	5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE...
T72654	(R)-PD 0325901CL
	(R)-PD 0325901CL为PD 0325901CL的异构体，后者为一种用于癌症研究的有丝分裂原活化蛋白激酶(MEK)选择性抑制剂，能够在体外和体内抑制癌细胞生长。
T83924	(R)-(+)-Deoxyarbutin
	(R)-(+)-Deoxyarbutin 是 deoxyarbutin 的一个异构体，同时也是一种酪氨酸酶抑制剂。在 21 µM 的浓度下，它能够抑制酪氨酸酶的活性。(R)-(+)-Deoxyarbutin (1%) 能够使无毛的深色、中等和浅色皮肤豚鼠的皮肤变亮。
T35465	(±)16-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits pro...

化合物

BAY-598 R-isomer

Cat.No: T26744

Synonym: BAY598 R-isomer,BAY 598 R-isomer

(R)-CR8 trihydrochloride

Cat.No: T12617

Synonym: CR8, (R)-Isomer trihydrochloride

Target: Apoptosis, CDK

INCB3344 R-isomer

Cat.No: T11650

Target: Others

(S, R)-LSN 3318839

Cat.No: T63166L

Synonym: (S, R)-LSN 3318839(Isomer-2764704-18-7)

Target: Glucagon Receptor

Cat.No: T12617L

Synonym: (R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8

Target: Apoptosis, CDK

MKC-963 (R-isomer)

Cat.No: T70544

Oxybutynin R-isomer HCl

Cat.No: T71236

ISRIB (trans-isomer)

Cat.No: T6183

Synonym: ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB

Target: Apoptosis, PERK, Autophagy

Midodrine (R-isomer HCl)

Cat.No: T33384

Synonym: ProAmatine,Midodrine,ST-1085,Gutron,Amatine

BAY-6035-R-isomer

Cat.No: T69703

Cat.No: TD0058

Synonym: 四甲基罗丹明-6-异硫氰酸（单一化合物）,R isomer [Tetramethylrhodamine-6-isothiocyanate]

(R)-Carisbamate

Cat.No: T5517

Target: Others

Cat.No: T26914L

Target: Others

(R)-Viloxazine Hydrochloride

Cat.No: T22413

Target: Others

1,2-diphenylpropan-2-amine

Cat.No: T50052

Target: Others

(R)-Lansoprazole

Cat.No: T1021

Synonym: Dexlansoprazole,右旋兰索拉唑,T 168390,TAK 390,R-(+)-Lansoprazole

Target: Proton pump

Cat.No: T68002L

Synonym: 4-[4-[(5-Thio-α-D-xylopyranosyl)thio]benzoyl]benzonitrile(Isomer-120819-70-7)

Target: Others

Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-

Cat.No: T63898

Target: PPAR

Alprenolol tartrate, (R)-

Cat.No: T29905

Cat.No: T17307

Synonym: DR3354,D-Ofloxacin,DR-3354,DR 3354,(R)-氧氟沙星,(R)-(+)-Ofloxacin,(+)-Ofloxacin

Target: Others

Cat.No: T12611

Target: Others

Cat.No: T21265

Synonym: D-Amlodipine,(R)-(+)-Amlodipine,(+)-Amlodipine

Cat.No: T13442

Target: Others

Cat.No: T70780

Cat.No: T12621

Target: Others

Adrafinil, (R)-

Cat.No: T29671

Synonym: UNII-Z61JQF40LJ,Adrafinil (R)-,R-(+)-Adrafinil

Dabelotine, (R)-

Cat.No: T31176

Synonym: UNII-3NZJ1HNE7Y

Cat.No: T26266

Synonym: L-PIA,(R)-PIA,(R)- PIA,(R)-PIA,L-2-N6-(Phenylisopropyl)adenosine

(R)-Dihydrolipoic acid

Cat.No: T21234

Cat.No: T37227

Fmoc-Gly-Gly-D-Phe-OtBu

Cat.No: T17951

Target: Others

Cat.No: T61309

Cat.No: T72820

Synonym: (R)-GW679769

Cat.No: T72913

(R)-Omeprazole (sodium salt)

Cat.No: T36840

Cat.No: T38031

Synonym: (R)-KT109

Cat.No: T62881

Cat.No: T35467

Cat.No: T70430

Cat.No: T71736

Cat.No: T73507

Synonym: (R)-SPD502

Cat.No: T36608

Cat.No: T38148

Synonym: (S)-KT109

(Rac)-Etavopivat

Cat.No: T72663

Synonym: (Rac)-FT-4202

Streptonigrin (racemate)

Cat.No: T71483

Cat.No: T12634

Target: Others

5(S),6(R)-11-trans DiHETE

Cat.No: T37651

(R)-PD 0325901CL

Cat.No: T72654

(R)-(+)-Deoxyarbutin

Cat.No: T83924

Cat.No: T35465

Cat. No.	Product Name	Target	Signaling Pathways
T5302	(R)-pyrrolidine-2-carboxylic acid D-脯氨酸,D-Proline	Others; Endogenous Metabolite	Metabolism; Others
	(R)-pyrrolidine-2-carboxylic acid (D-Proline) 是天然氨基酸 L -脯氨酸的异构体。D -氨基酸在人类血浆和唾液中含量相对较高。这些氨基酸可能是细菌来源，但也有证据表明它们是通过氨基酸消旋酶活性内源性产生的。
T74193	(R)-IDHP
	(R)-IDHP为IDHP异构体，属于丹参代谢物。该化合物能通过抑制血管平滑肌细胞电压依赖性钙通道与受体操作钙通道的Ca2+释放和Ca2+内流，发挥血管松弛作用，适用于心脑血管疾病研究。

天然产物

(R)-pyrrolidine-2-carboxylic acid

Cat.No: T5302

Synonym: D-脯氨酸,D-Proline

Target: Others, Endogenous Metabolite

Cat.No: T74193

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼