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Cat. No.	Product Name	Target	Signaling Pathways
T3521	γ-Secretase-IN-1 Compound E	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	γ-Secretase-IN-1 是一种高效的 γ-secretase 抑制剂，对T-47D 细胞显示部分抗增殖活性且抑制 β-amyloid(40)，β-amyloid(42)，和Notch γ-分泌酶裂解。
T11358	gamma-secretase modulator 1 N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	gamma-secretase modulator 1 是一种 γ 分泌酶的调节剂，可用于治疗阿尔茨海默病的研究。
T9641	Aβ42-IN-2	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aβ42-IN-2 是一种 γ-secretase 调节剂。Aβ42-IN-2 对 Αβ42 的 IC50 值为 6.5 nM 。Aβ42-IN-2 可用于阿尔茨海默症相关的研究。
T22678	3,5-Bis(4-nitrophenoxy)benzoic acid 3,5-二(4-硝基苯氧基)苯甲酸,Compound W	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) 是 γ-secretase 抑制剂。它导致 Aβ42 和 notch-1 Aβ-like peptide 25 (Nβ25) 的释放水平降低。它是母体血清中 3,3’-diiodothyronine sulfate (T2S) 的交叉反应物质，可作为胎儿甲状腺功能减退的标志物。
T63208	Aβ-IN-1	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aβ-IN-1 是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ-IN-1 在不抑制 CYP3A4 的情况下，在培养细胞中有效降低 Aβ42 水平，IC50值为 0.091 μM。Aβ-IN-1 显示出良好的药代动力学特征。
T11043	Dihydroergocristine mesylate 甲磺酸双氢麦角汀,DHEC (mesylate)	Beta Amyloid	Neuroscience
	Dihydroergocristine mesylate (DHEC (mesylate)) 是一种 γ-secretase (GSI) 的抑制剂，能够阿尔茨海默氏病淀粉样蛋白 β 肽 (amyloid-β) 的产生，与 γ-secretase 和 Nicastrin 结合的平衡解离常数 (Kd) 值分别为 25.7 nM 和 9.8 μM。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T13037	Sulindac sulfide cis-Sulindac sulfide	Raf; Others; AChR	MAPK; Neuroscience; Others
	Sulindac sulfide (cis-Sulindac sulfide) 是一种非甾体抗炎化合物，对COX-1具有很高的亲和力，是Ras 激活Raf-1的抑制剂。Sulindac sulfide 是 γ-secretase 的一个非竞争性抑制剂， IC50 为 20.2 μM。它是舒林酸的活性代谢物。
T3633	Crenigacestat LY3039478	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂，其在多种肿瘤细胞中的IC50为 ∼1nM。
T11359	gamma-secretase modulator 2	Others	Others
	gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease .γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
T61881	γ-Secretase modulator 12
	γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1].
T10443	Aβ42-IN-1 free base	Others	Others
	Aβ42-IN-1 free base是一种口服活性的γ-secretase调节剂，具有高暴露度。该化合物能显著降低小鼠脑中Aβ42的水平，IC50为0.091 μM，显示出在阿尔茨海默病研究中的潜力。
T10589L	BPN-15606	Others	Others
	BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavai
T10211	Aβ42-IN-1	Others	Others
	Aβ42-IN-1，化合物 1v，是一种新型有效且具有口服活性的 γ 分泌酶调节剂 (GSM)。 Aβ42-IN-1 在不抑制 CYP3A4 的情况下，在培养细胞中有效降低Aβ42水平，IC50值为 0.091 μM。Aβ42-IN-1 显示出良好的药代动力学特征。
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。

化合物

γ-Secretase-IN-1

Cat.No: T3521

Synonym: Compound E

Target: Beta Amyloid, Gamma-secretase

gamma-secretase modulator 1

Cat.No: T11358

Synonym: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine

Target: Gamma-secretase

Cat.No: T9641

Target: Gamma-secretase

3,5-Bis(4-nitrophenoxy)benzoic acid

Cat.No: T22678

Synonym: 3,5-二(4-硝基苯氧基)苯甲酸,Compound W

Target: Gamma-secretase

Cat.No: T63208

Target: Gamma-secretase

Dihydroergocristine mesylate

Cat.No: T11043

Synonym: 甲磺酸双氢麦角汀,DHEC (mesylate)

Target: Beta Amyloid

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Sulindac sulfide

Cat.No: T13037

Synonym: cis-Sulindac sulfide

Target: Raf, Others, AChR

Cat.No: T3633

Synonym: LY3039478

Target: Gamma-secretase

gamma-secretase modulator 2

Cat.No: T11359

Target: Others

γ-Secretase modulator 12

Cat.No: T61881

Aβ42-IN-1 free base

Cat.No: T10443

Target: Others

Cat.No: T10589L

Target: Others

Cat.No: T10211

Target: Others

Cat.No: T76393

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