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Search Results for " αvβ3 integrin "

32

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6812L	Cyclo(-RGDfK) TFA	Integrin	Cytoskeletal Signaling
	Cyclo(-RGDfK) TFA 是一种选择性整合素αvβ3的有效抑制剂，其IC50值为 0.94 nM。它通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。
T6812	Cyclo(-RGDfK) Cyclo (-RGDfK)	Integrin	Cytoskeletal Signaling
	Cyclo(-RGDfK) (Cyclo (-RGDfK)) 是一种选择性整合素αvβ3的有效抑制剂，IC50值为 0.94 nM。它通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。
TP1474	LXW7	Integrin	Cytoskeletal Signaling
	LXW7 是一种整合素αvβ3抑制剂，是含 Arg-Gly-Asp (RGD) 的环状肽，对αvβ3整联蛋白具有很高的结合亲和力，IC50为 0.68 μM。它可增强 VEGFR-2 磷酸化和 ERK1/2 活化，具有抗炎活性。
TP1879L1	P11 acetate	Integrin	Cytoskeletal Signaling
	P11 acetate 是一种整合素 αvβ3-玻连蛋白相互作用拮抗剂 (IC50 = 2.74 nM)。
T6813	Cyclo(RGDyK) trifluoroacetate Cyclo(RGDyK)	Integrin	Cytoskeletal Signaling
	Cyclo(RGDyK) trifluoroacetate 是一种选择性αVβ3整联蛋白抑制剂，IC50为 20 nM。
T6657	SB273005	Integrin	Cytoskeletal Signaling
	SB273005 是一种有效的整合素抑制剂，对 αvβ3 受体和 αvβ5 受体的 Ki 分别为 1.2 nM 和 0.3 nM。
T2494	Cilengitide 西仑吉肽,EMD 121974	Integrin; Autophagy	Autophagy; Cytoskeletal Signaling
	Cilengitide (EMD 121974) 是一种有效的 αvβ3/5 受体整合素抑制剂，可抑制 ανβ3和 ανβ5与玻连蛋白结合，IC50值分别为 4 和 79 nM。
TP1459L	Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)	Integrin	Cytoskeletal Signaling
	Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base) 是一种源自纤连蛋白的细胞结合区域的细胞结合蛋白结构域。
T16085	MK-0429 L-000845704	Others	Others
	MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).
TP2148	LXW7 TFA (1313004-77-1 free base) LXW7 TFA	Integrin	Cytoskeletal Signaling
	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3 integrin (IC50: 0.68 μM). It increases the phosphorylation of VEGFR-2 and activation of ERK1/2.
TQ0250	CWHM-12	Integrin	Cytoskeletal Signaling
	CWHM-12 是 αV 整合素的有效抑制剂，抑制αvβ8、αvβ3、αvβ6和αvβ1，IC50 为 0.2、0.8、1.5 和 1.8 nM。
TP2390	Maraciclatide NC-100692,NC 100692,NC100692
	Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin.
TP1879	HSDVHK-NH2 P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T8726	Cyclo(RGDyK)	Integrin	Cytoskeletal Signaling
	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
T15584	Integrin Antagonists 27	Others	Others
	Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.
T69460	TSRI265
	TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.
T11663	Integrin-IN-2	Others	Others
	Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.
T68462	D-Ornithine lactam
	D-Ornithine lactam is a building block. It has been used in the synthesis of hepatitis C virus non-structural protein 5B inhibitors, as well as αVβ3 integrin receptor antagonists.
T6806	Cilengitide TFA	Integrin; Autophagy	Autophagy; Cytoskeletal Signaling
	Cilengitide TFA 是一种选择性的 αvβ3和 αvβ5受体整合素抑制剂，IC50分别为 4 nM 和 79 nM。对 GP IIb/IIIa 的选择性约为 10 倍。
T10920	Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA	Others	Others
	Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3.
T76068	Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
	Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA 是一种环状RGD多肽，对αvβ3有高亲和性，能干扰细胞整合素之间的相互作用。此化合物能抑制胚胎干细胞(ESC)的多潜能性基因表达，并可在体内减少mESC的致瘤潜力，因此适用于肿瘤研究领域。
T75724	LXW7 TFA
	LXW7 TFA, 包含 Arg-Gly-Asp (RGD) 的环状肽，作为整合素αvβ3抑制剂，展示出对αvβ3整联蛋白高度的结合亲和力，其IC50值为0.68 μM。此外，LXW7 TFA 能够促进 VEGFR-2 磷酸化和 ERK1/2 激活，显示出抗炎活性。
T82516	E(c(RGDfK))₂
	E(c(RGDfK))是一种针对αvβ3整联蛋白的特异性结合片段，表现出对肿瘤的靶向作用。在人卵巢癌OVCAR-3异种移植肿瘤模型中，该化合物的摄取有所提升，适用于癌症研究领域。
T75990	Cyclo(Arg-Gly-Asp-D-Phe-Val)
	Cyclo(Arg-Gly-Asp-D-Phe-Val) 为一种整合素αvβ3抑制剂，具有抗肿瘤活性，并可用于急性髓系白血病的研究。
T76807	Etaracizumab
	Etaracizumab (LM 609)，一种αvβ3整合素IgG1单克隆抗体，具有抑制血管生成和黑色素瘤生长的作用，可用于抗癌研究。
T75835	HSDVHK-NH2 TFA
	HSDVHK-NH2 TFA 作为一种整合素 αvβ3-玻璃体结合蛋白的互作拮抗剂，其IC50值达到1.74 pg/mL (2.414 pM)。
TP1974	Obtustatin
	Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum
T83736	RTDLDSLRTYTL TFA
	RTDLDSLRTYTL是一种αVβ6整合素配体。它选择性地抑制纤维连接蛋白与αVβ6整合素的结合，相比之下，对于纤维连接蛋白与αVβ3或αVβ5以及纤维蛋白原与αIIβ3的结合则几乎不产生影响（IC50分别为0.02, >50, >50, 和 >50 µM）。此外，RTDLDSLRTYTL还能以浓度依赖的方式抑制HT-29结肠癌细胞与纤维连接蛋白的结合。
T74400	TC113
	TC113是一种与c(RGDyK)偶联的Gemcitabine。它通过整合素αvβ3可被A549细胞内化。此外，TC113对WM266.4和A549细胞表现出显著的抗增殖效果。
T78064	Synstatin (92-119) SSTN92-119	Integrin	Cytoskeletal Signaling
	Synstatin (92-119)为一种抗肿瘤化合物，它能够抑制血管生成与癌细胞侵袭，通过下调整合素αvβ3，降低VEGF与FGF-2的活化。
TP2098	Echistatin Echistatin, α1 isoform
	Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3)
T75761	Gly-Arg-Gly-Asp-Ser TFA GRGDS TFA
	Gly-Arg-Gly-Asp-Ser (TFA) 是一种与糖蛋白和骨桥蛋白在细胞结合域中起作用的五肽。该化合物能够与整合素整联蛋白受体αvβ3和αvβ5结合，其IC50值分别约为5 μM和6.5 μM。

化合物

Cyclo(-RGDfK) TFA

Cat.No: T6812L

Target: Integrin

Cat.No: T6812

Synonym: Cyclo (-RGDfK)

Target: Integrin

Cat.No: TP1474

Target: Integrin

Cat.No: TP1879L1

Target: Integrin

Cyclo(RGDyK) trifluoroacetate

Cat.No: T6813

Synonym: Cyclo(RGDyK)

Target: Integrin

Cat.No: T6657

Target: Integrin

Cat.No: T2494

Synonym: 西仑吉肽,EMD 121974

Target: Integrin, Autophagy

Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)

Cat.No: TP1459L

Target: Integrin

Cat.No: T16085

Synonym: L-000845704

Target: Others

LXW7 TFA (1313004-77-1 free base)

Cat.No: TP2148

Synonym: LXW7 TFA

Target: Integrin

Cat.No: TQ0250

Target: Integrin

Cat.No: TP2390

Synonym: NC-100692,NC 100692,NC100692

Cat.No: TP1879

Synonym: P11

Cat.No: T8726

Target: Integrin

Integrin Antagonists 27

Cat.No: T15584

Target: Others

Cat.No: T69460

Integrin-IN-2

Cat.No: T11663

Target: Others

D-Ornithine lactam

Cat.No: T68462

Cilengitide TFA

Cat.No: T6806

Target: Integrin, Autophagy

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

Cat.No: T10920

Target: Others

Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA

Cat.No: T76068

Cat.No: T75724

Cat.No: T82516

Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cat.No: T75990

Cat.No: T76807

Cat.No: T75835

Cat.No: TP1974

RTDLDSLRTYTL TFA

Cat.No: T83736

Cat.No: T74400

Synstatin (92-119)

Cat.No: T78064

Synonym: SSTN92-119

Target: Integrin

Cat.No: TP2098

Synonym: Echistatin, α1 isoform

Gly-Arg-Gly-Asp-Ser TFA

Cat.No: T75761

Synonym: GRGDS TFA

Cat. No.	Product Name	Target	Signaling Pathways
T36715	Tetrac Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tetrac (Tetraiodothyroacetic acid)是L-甲状腺素(T4)的衍生物，是一种甲状腺整合素受体拮抗剂。Tetrac通过阻断EGFR介导的结直肠癌细胞信号传导来诱导抗增殖。Tetrac 可阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3)在细胞表面甲状腺素整合素 αvβ3 受体上的作用。Tetra 具有抗血管生成、抗肿瘤活性和促凋亡活性。
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Cat.No: T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

Cat.No: T36295

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