Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lefamulin (BC-3781) 是一种半合成化合物,可抑制细菌生长所需的细菌蛋白质的合成。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,320 | 现货 | ||
25 mg | ¥ 6,890 | 现货 | ||
50 mg | ¥ 9,330 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 25,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,490 | 现货 |
产品描述 | Lefamulin (BC-3781) is a semi-synthetic compound that inhibits the synthesis of bacterial protein, which is required for bacteria to grow. |
体内活性 | Lefamulin exhibits a unique mechanism of action through inhibition of protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer. Lefamulin displays activity against gram-positive and atypical organisms associated with CABP (i.e., Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae), with an expanded gram-positive spectrum including Staphylococcus aureus (i.e., methicillin-resistant, vancomycin-intermediate, and heterogeneous strains) and vancomycin-resistant Enterococcus faecium. Lefamulin was also shown to retain activity against multidrug-resistant Neisseria gonorrhoeae and Mycoplasma genitalium. Lefamulin exhibits time-dependent killing, and the pharmacodynamic target best associated with antibacterial activity is ?AUC0-24?/MIC (minimum inhibitory concentration [MIC]). |
别名 | BC-3781 |
分子量 | 507.73 |
分子式 | C28H45NO5S |
CAS No. | 1061337-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (98.48 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9696 mL | 9.8478 mL | 19.6955 mL | 49.2388 mL |
5 mM | 0.3939 mL | 1.9696 mL | 3.9391 mL | 9.8478 mL | |
10 mM | 0.197 mL | 0.9848 mL | 1.9696 mL | 4.9239 mL | |
20 mM | 0.0985 mL | 0.4924 mL | 0.9848 mL | 2.4619 mL | |
50 mM | 0.0394 mL | 0.197 mL | 0.3939 mL | 0.9848 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lefamulin 1061337-51-6 Others BC-3781 BC 3781 BC3781 Inhibitor inhibitor inhibit