Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Difluprednate (Myser) 是一种可用于术后眼睛疼痛和炎症的皮质类固醇。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 147 | 现货 | ||
10 mg | ¥ 196 | 现货 | ||
25 mg | ¥ 316 | 现货 | ||
50 mg | ¥ 455 | 现货 | ||
100 mg | ¥ 745 | 现货 | ||
200 mg | ¥ 1,130 | 现货 | ||
500 mg | ¥ 1,990 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 273 | 现货 |
产品描述 | Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain. |
体外活性 | The difluprednate emulsion formulation begin by suspending DFBA in a variety of oils (castor, cottonseed, medium-chain fatty acid triglyceride, oleic, olive, peanut, and soybean). [1] Difluprednate ophthalmic emulsion's active metabolite, 6α,9-difluoroprednisolone 17-butyrate (DFB), has the lowest Ki value (611 nM) for the glucocorticoid receptor and is significantly more active than prednisolone, which has a Ki value of 3.4 nM. [2] |
体内活性 | Difluprednate emulsion is rapidly deacetylated in the aqueous humor to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug's active metabolite, which has a similar corticosteroid activity profile. Radio-labeled difluprednate is instilled in the right eyes of pigmented rabbits in a separate study examining DFBA excretion. Difluprednate (0.05% emulsion) results in higher aqueous humor concentrations than the suspension form in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically significant inhibition of inflammation compared to saline in a rabbit model, with the anti-inflammatory response proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three concentration (0.002%, 0.01%, and 0.05%) in a dose-dependent manner in rats, and difluprednate 0.05% shows statistically superior anti-inflammatory activity compared to Betamethasone (0.1%). [1] |
别名 | Myser, Epitopic, 二氟孕甾丁酯, CM 9155 |
分子量 | 508.55 |
分子式 | C27H34F2O7 |
CAS No. | 23674-86-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 24 mg/mL (47.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (98.32 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 1.9664 mL | 9.8319 mL | 19.6637 mL | 49.1594 mL |
5 mM | 0.3933 mL | 1.9664 mL | 3.9327 mL | 9.8319 mL | |
10 mM | 0.1966 mL | 0.9832 mL | 1.9664 mL | 4.9159 mL | |
20 mM | 0.0983 mL | 0.4916 mL | 0.9832 mL | 2.458 mL | |
DMSO | 50 mM | 0.0393 mL | 0.1966 mL | 0.3933 mL | 0.9832 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Difluprednate 23674-86-4 Others Myser Epitopic inhibit Phospholipase CM9155 二氟孕甾丁酯 Inhibitor CM 9155 CM-9155 inhibitor