首页工具

登录

搜索结果

Search Results for " gpx "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T67970	GPX-100 13-deoxydoxorubicin	Others	Others
	GPX-100 (13-deoxydoxorubicin) 是蒽环类抗肿瘤抗生素多柔比星的类似物。GPX-100 插入DNA 并与拓扑异构酶II 相互作用，从而抑制DNA 复制和修复以及RNA 和蛋白质合成。
T68928	GPX100 HCl
	GPX-100 is a n analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
T77759	GPX4-IN-6	GPX	oxidation-reduction
	GPX4-IN-6 是一种小分子共价 GPX4 抑制剂（IC50: 0.12 μM），具有抗肿瘤活性。GPX4-IN-6 可促使铁死亡，用于治疗=和预防三阴性乳腺癌 (TNBC)。
T77755	GPX4-IN-5	GPX	oxidation-reduction
	GPX4-IN-5 是一种小分子共价 GPX4 抑制剂（IC50: 0.12 μM），具有抗肿瘤活性。GPX4-IN-5 可促使铁死亡，可用于预防和治疗三阴性乳腺癌 (TNBC)。
T69668	CCW 28-3
	CCW 28-3 is a novel potent covalent BRD4 degrader, degrading BRD4 in a proteasome- and RNF4-dependent manner without inhibiting RNF4 autoubiquitination activity.
T74846	GPX4-IN-4	Glutathione Peroxidase	Metabolism
	GPX4-IN-4（Compound 24）作为一种GPX4抑制剂，具有显著效能，主要应用于癌症领域的科学研究。
T83780	GPX4 24 Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
	GPX4 24是(1S,3R)-RSL3的衍生物，具有抑制谷胱甘肽过氧化物酶4（GPX4）的作用。它能够在浓度依赖的方式中与4T1小鼠乳腺癌细胞中的GPX4形成共价结合。在GPX4依赖的HT-1080成纤维细胞中，GPX4 24诱导铁死亡（EC50 = 0.16 µM）。当以200 mg/kg剂量给予小鼠时，它能够增加小鼠肾脏和血浆中丙二醛（MDA）的水平。
T73235	GPX4-IN-2
	GPX4-IN-2 是一种有效的 GPX4抑制剂。GPX4 显示出抗增殖活性。GPX4-IN-2具有癌症研究的潜力。
T63729	GPX4-IN-3
	GPX4-IN-3 (26a) 作为一种有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂，其能选择性诱导铁死亡（ferroptosis）。在1 μM浓度下，该化合物能抑制GPX4活性达71.7%。
T79777	GPX4-IN-7	Ferroptosis	Apoptosis
	GPX4-IN-7 (Compound 31)，一种靛玉红衍生物，作为结肠癌铁死亡的诱导剂，对HCT-116细胞显示出卓越的抗肿瘤效果，IC50为0.49 μM。该化合物通过促进GPX4降解和脂质ROS积累，有效触发铁死亡。
T74796	PROTAC GPX4 degrader-1
	PROTACGPX4 degrader-1 (DC-2) 是GPX4的PROTAC 降解剂，其在HT1080 细胞中的DC50值为 0.03 μM。
T21899	Misonidazole SR-1354,SR1354,Ro 7-0582	GPX	oxidation-reduction
	Misonidazole 是一种缺氧肿瘤细胞放射增敏剂，具有抗菌活性。
T69669	Camsirubicin HCl
	Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.
T36516	RC574 RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor ...
T63768	Antitumor agent-78
	Antitumor agent-78 能够抑制 GPx-4 和升高 COX2 ，进而导致铁下垂 (ferroptosis)。Antitumor agent-78 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3)，抑制肿瘤细胞上皮间质转化 (EMT) 过程。Antitumor agent-78 表现出抗肿瘤效果，并能够抑制癌细胞的生长和迁移。
T11357	Gamma-glutamylcysteine TFA γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)	IL Receptor	Immunology/Inflammation
	Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
T62814	Antitumor agent-77
	Antitumor agent-77 对癌细胞的生长和迁移具有抑制作用，具有抗癌作用。Antitumor agent-77 能够抑制 GPx-4 和提高 COX2 引发铁下垂。Antitumor agent-77 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3)，阻碍肿瘤细胞上皮间质转化 (EMT) 过程。
T36515	RC363
	RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT2...

化合物

Cat.No: T67970

Synonym: 13-deoxydoxorubicin

Target: Others

Cat.No: T68928

Cat.No: T77759

Target: GPX

Cat.No: T77755

Target: GPX

Cat.No: T69668

Cat.No: T74846

Target: Glutathione Peroxidase

Cat.No: T83780

Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

Cat.No: T73235

Cat.No: T63729

Cat.No: T79777

Target: Ferroptosis

PROTAC GPX4 degrader-1

Cat.No: T74796

Cat.No: T21899

Synonym: SR-1354,SR1354,Ro 7-0582

Target: GPX

Camsirubicin HCl

Cat.No: T69669

Cat.No: T36516

Synonym: RC574

Antitumor agent-78

Cat.No: T63768

Gamma-glutamylcysteine TFA

Cat.No: T11357

Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

Target: IL Receptor

Antitumor agent-77

Cat.No: T62814

Cat.No: T36515

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼