Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCPA (2-chloro-N(6)cyclopentyladenosine) 是一种有效的选择性腺苷 A1 受体激动剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 638 | 现货 | ||
5 mg | ¥ 1,580 | 现货 | ||
10 mg | ¥ 2,320 | 现货 | ||
25 mg | ¥ 3,950 | 现货 | ||
50 mg | ¥ 5,530 | 现货 | ||
100 mg | ¥ 7,530 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,730 | 现货 |
产品描述 | CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor |
靶点活性 | A1 receptor:40 nM |
体外活性 | CCPA suppressed the mRNA and protein expressions of CnAβ and exerted antihypertrophic effects to a greater degree than CsA. The inhibition of CCPA on cardiomyocyte hypertrophy was counteracted by the A1 receptor antagonist DPCPX[1]. |
体内活性 | CCPA (CCPA) was synthesized as a potential high affinity ligand for A1 adenosine receptors. Binding of [3H]PIA to A1 receptors of rat brain membranes was inhibited by CCPA with a Ki-value of 0.4 nM, compared to a Ki-value of 0.8 nM for the parent compound N6-cyclopentyladenosine (CPA)[2]. |
别名 | 2-chloro-N(6)cyclopentyladenosine, 2-氯-N6-环戊基腺苷, 2-CHLORO-N-CYCLOPENTYLADENOSINE |
分子量 | 369.8 |
分子式 | C15H20ClN5O4 |
CAS No. | 37739-05-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (148.73 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7042 mL | 13.5208 mL | 27.0416 mL | 67.6041 mL |
5 mM | 0.5408 mL | 2.7042 mL | 5.4083 mL | 13.5208 mL | |
10 mM | 0.2704 mL | 1.3521 mL | 2.7042 mL | 6.7604 mL | |
20 mM | 0.1352 mL | 0.676 mL | 1.3521 mL | 3.3802 mL | |
50 mM | 0.0541 mL | 0.2704 mL | 0.5408 mL | 1.3521 mL | |
100 mM | 0.027 mL | 0.1352 mL | 0.2704 mL | 0.676 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CCPA 37739-05-2 GPCR/G Protein Neuroscience Adenosine Receptor 2-chloro-N(6)cyclopentyladenosine 2 Chloro N6 cyclopentyladenosine 2-Chloro-N-6-cyclopentyladenosine 2-氯-N6-环戊基腺苷 2-CHLORO-N-CYCLOPENTYLADENOSINE 2ChloroN6cyclopentyladenosine Inhibitor inhibitor inhibit