Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T14352 | Autotaxin-IN-1
化合物 T14352
|
1619971-30-0 | 98% |
|
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat... | ||||
T10481L | BAY 73-6691
化合物 T10481L
|
794568-92-6 | 98% |
|
BAY 73-6691 is an inhibitor of brain penetrant PDE9A. | ||||
T13232 | TyK2-IN-2
化合物 T13232
|
2098466-94-3 | 98% |
|
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα). | ||||
T38108 | Fulvic Acid
黄腐酸
|
479-66-3 | 98% |
|
Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物,是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化,破坏预先形成的AB17-42三聚体,并结合到磷酸二酯酶5A (PDE5A)的催化位点,可以调节机体免疫系... | ||||
T15766 | Lirimilast
化合物 T15766
|
329306-27-6 | 98% |
|
Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties... | ||||
TN1843 | Kushenol K
苦参醇K
|
101236-49-1 | 98% |
|
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s... | ||||
T16976 | TAK-915
化合物 T16976
|
1476727-50-0 | 98% |
|
TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than... | ||||
T10416 | Autotaxin-IN-4
化合物 T10416
|
2156655-86-4 | 98% |
|
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. | ||||
T10417 | Autotaxin-IN-5
化合物 T10417
|
2156655-99-9 | 98% |
|
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. | ||||
T15640 | K134
化合物 T15640
|
189362-06-9 | 98% |
|
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively. | ||||
T16272 | Naproxen etemesil
化合物 T16272
|
385800-16-8 | 98% |
|
Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naprox... | ||||
T10994L2 | Deltasonamide 2 (TFA)
化合物 T10994L2
|
2235358-74-2 | 98% |
|
Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. | ||||
T10350 | Apremilast-d5
化合物 T10350
|
1258597-47-5 | 98% |
|
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rele... | ||||
T9805 | BAY 2666605
化合物BAY 2666605
|
2275774-60-0 | 99.98% |
|
BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂,IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。 | ||||
TN2159 | Robustine
大叶桉亭
|
2255-50-7 | 99.97% |
|
Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱,在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。 | ||||
T0080 | Trapidil
唑嘧胺
|
15421-84-8 | 99.96% |
|
Trapidil (Avantrin) 是一种抗血小板药物,是一种血管扩张剂,有特异性血小板衍生生长因子。 | ||||
T2205 | Acefylline
茶碱乙酸
|
652-37-9 | 99.95% |
|
Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物,是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂,也是一种支气管扩张剂,可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。 | ||||
T1681 | Aminophylline
氨茶碱
|
317-34-0 | 99.94% |
|
Aminophylline (Phyllocontin) 是一种竞争性非选择性磷酸二酯酶抑制剂,具有支气管扩张作用。它是竞争性的腺苷受体拮抗剂,有用于哮喘研究的潜力。 | ||||
T1096 | Milrinone
米力农
|
78415-72-2 | 99.93% |
|
Milrinone (Win 47203) 是一种 PDE3抑制剂,也是一种强心药、血管舒张药。 | ||||
TN6120 | Nauclefine
牛蒡子苷
|
57103-51-2 | 99.92% |
|
Nauclefine (Parvine) 是一种植物吲哚生物碱天然产物,可通过 PDE3A-SLFN12 依赖性死亡途径诱导多种癌细胞的凋亡。 Nauclefine 结合 PDE3A 但不抑制 PDE3A 的磷酸二酯酶活性。 |