p38 MAPK

p38 MAPKs (α, β, γ, and δ) are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/6, the p38 MAPK kinases. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. p38 MAPK is involved in regulation of HSP27, MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and several transcription factors including ATF-2, Stat1, the Max/Myc complex, MEF-2, Elk-1, and indirectly CREB via activation of MSK1.

Cat. No.	Product Name	CAS No.	Purity
TN1211	2-Hydroxy-3-methylanthraquinone 化合物2-Hydroxy-3-methylanthraquinone	17241-40-6	98%
TN1211	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
T16477	PF-03715455 化合物 T16477	1056164-52-3	98%
T16477	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715...
T10298L	AMG-548 化合物 T10298L	864249-60-5	98%
T10298L	AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38...
TN3711	Corylifol C 化合物 TN3711	775351-91-2	98%
TN3711	Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
T10298L2	AMG-548 dihydrochloride (864249-60-5 free base) 化合物 T10298L2	T10298L2	98%
T10298L2	AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective...
TL0014	Pinusolide 化合物 TL0014	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN3719	Cristacarpin 化合物 TN3719	74515-47-2	98%
TN3719	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
TN5050	Sprengerinin C 化合物 TN5050	88861-91-0	98%
TN5050	Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
T11327	FR 167653 化合物 T11327	158876-66-5	98%
T11327	FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and s...
TN3839	Desoxo-narchinol A 化合物 TN3839	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN2075	Pimaric acid 海松酸	127-27-5	98%
TN2075	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human ...
TN4490	Manassantin B 化合物 TN4490	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
TN1882	Lucidenic acid D 赤芝酸D	98665-16-8	98%
TN1882	Lucidenic acid D2 is a nartural product from G. lucidum AF.
T3229	Cytochalasin D 细胞松弛素D	22144-77-0	98%
T3229	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
TN2039	Panaxydol 人参环氧炔醇	72800-72-7	98%
TN2039	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MA...
T12871L	Talmapimod hydrochloride 化合物 T12871L	309915-12-6	98%
T12871L	Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fol...
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 化合物 TN3931	57719-81-0	98%
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN4162	Goshonoside F5 化合物 TN4162	90851-28-8	98%
TN4162	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
T36067	Bongkrekic acid 米酵菌酸	11076-19-0	98%
T36067	Bongkrekic acid (Bongkrekic Acid (ammonium salt)) 是一种由伯克霍尔德菌（Burkholderia gladioli）分泌的线粒体毒素，抑制腺嘌呤核苷酸转位酶（ANT）。Bongkrekic acid Bongkrekic acid 通过 p38、ERK、PAD4 和 P...
TMA0291	Dehydroglyasperin D 化合物 TMA0291	517885-72-2	98%
TMA0291	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...