NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product Name	CAS No.	Purity
T79930	Sanggenon A 桑根酮A	76464-71-6	98%
T79930	Sanggenon A通过调控BV2和RAW264.7细胞中的NF-κB及HO-1/Nrf2信号途径，展现了抗炎效果。该化合物明显抑制了由脂多糖(LPS)引起的一氧化氮产生。
T79932	Eudebeiolide B 化合物 Eudebeiolide B	1934299-51-0	98%
T79932	Eudebeiolide B，一种自荔枝草分离得的化合物，能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成，适用于研究与破骨细胞相关的疾病。
T79933	(−)-N-Hydroxyapiosporamide 化合物 (−)-N-Hydroxyapiosporamide	1205676-02-3	98%
T79933	(−)-N-Hydroxyapiosporamide (NHAP)为生物碱类NF-κB抑制剂，表现出体外及体内抗肿瘤活性，常用于结直肠癌(CRC)研究。
T79999	NF-κB-IN-13 化合物 NF-κB-IN-13	117596-92-6	98%
T79999	NF-κB-IN-13（compound 12）在RAW264.7巨噬细胞中显著抑制了LPS诱导的NF-κB激活以及NO生成，表现出其抗炎效果。
T80062	Mitogen-activated protein kinase 1 化合物 Mitogen-activated protein kinase 1	137632-08-7	98%
T80062	Mitogen-activated protein kinase1 (MAPK1) 能够激活下游的 p38/NF-κB 通路，并调控多种与脓毒症相关的疾病细胞过程。此外，MAPK1 通过磷酸化催化底物蛋白，起到调节底物蛋白活性开关的作用。
T80208	Tripeptide-41 化合物 Tripeptide-41	1093241-16-7	98%
T80208	Tripeptide-41(CG-Lipoxyn)作为一种生物活性肽，具备降低脂肪积聚的功能，常见于化妆品成分应用。
T82022	IVMT-Rx-3 化合物 IVMT-Rx-3		98%
T82022	IVMT-Rx-3是针对SDCBP的PDZ1和PDZ2结构域，特别是MDA-9/Syntenin的抑制剂。该化合物能够中断MDA-9/Syntenin与Src之间的互动，减少NF-κB的激活，并且降低MMP-2/MMP-9的表达量，从而抑制了黑色素瘤的转移。
T82049	IR-Crizotinib 化合物 IR-Crizotinib	2387927-74-2	98%
T82049	IR-Crizotinib是一种结合了近红外染料IR-786和Crizotinib的复合物，能穿透血脑屏障及在小鼠颅内荧光定位GBM。作为NIK抑制剂，其IC50值为3.381 μM，既能有效抑制胶质瘤细胞体外生长及侵袭，也适用于体内研究，对癌症治疗具有研究意义。
T82665	CTP-NBD 化合物 CTP-NBD	1268513-27-4	98%
T82665	CTP-NBD (CTP-NBD) 是一种具有细胞渗透性的特异性 NFκB (NFκB) 抑制剂，常用于结肠炎研究。
T83052	Anti-inflammatory agent 60 化合物 Anti-inflammatory agent 60		98%
T83052	Anti-inflammatory agent 60 (compound 21) 的 IC50 值针对一氧化氮生成为 12.95 μM。此化合物通过浓度依赖性方式降低 iNOS、phosphorylated p65 以及 β-catenin 的表达。
TN4038	Eupatolide 泽兰内酯	6750-25-0	98%
TN4038	Eupatolide 是从 Inula japonica 的花中分离出来的，具有抗炎活性。 Eupatolide 可用于研究乳腺癌细胞对 TRAIL 的耐药性。
TN3587	Capillarisin 化合物 TN3587	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN1806	Isotetrandrine 异汉防己甲素	477-57-6	98%
TN1806	Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of...
TN1485	Chicanine 襄五脂素	78919-28-5	98%
TN1485	Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
TN2095	Pomiferin 橙桑黄酮	572-03-2	98%
TN2095	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has a...
TMA1777	Hydrangenol 8-O-glucoside 化合物 TMA1777	67600-94-6	98%
TMA1777	Hydrangenol 8-O-glucoside may have anti-inflammary activity.
TN3410	Anatabine 化合物 TN3410	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4633	Neocryptotanshinone II 化合物 TN4633	27468-20-8	98%
TN4633	Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-ÎºB and iNOS signaling pathways.
TN4263	Isoangustone A 化合物 TN4263	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T4366	Quinovic acid 化合物 T4366	465-74-7	98%
T4366	Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...