NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product Name	CAS No.	Purity
TN1764	Incensole acetate 因香酚乙酸酯	34701-53-6	98%
TN1764	Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation.
TN3219	7,8-Didehydrocimigenol 化合物 TN3219	150972-72-8	98%
TN3219	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN2451	Isosalvianolic acid B 异丹酚酸B	930573-88-9	98%
TN2451	Isosalvianolic acid B is a natural from Salviae miltiorrhizae
TN3708	Coronarin D 化合物 TN3708	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
TN4652	Niazimicin 化合物 TN4652	147821-49-6	98%
TN4652	Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
TN5011	Shizukaol B 化合物 TN5011	142279-40-1	98%
TN5011	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
T13625	Coronalolic acid 化合物 T13625	268214-52-4	98%
T13625	Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
T21577	Narasin (sodium salt) 海南霉素	58331-17-2	98%
T21577	Narasin (sodium salt) (HainanMycin) 通过神经胶质瘤细胞中的 ER 应激诱导肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 介导的细胞凋亡，并通过抑制 IκBα 的磷酸化来抑制 NF-κB 信号传导。
T10318	Anatabine dicitrate 化合物 T10318	T10318	98%
T10318	Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β...
TN2164	Rubipodanone A 化合物Rubipodanone A	2170211-22-8	98%
TN2164	Rubipodanone A is a natural product
TN4774	Physalin A 化合物 TN4774	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN1846	Kushenol W 苦参醇W	254886-76-5	98%
TN1846	Kushenol W is a natural product
TN4437	Licorisoflavan A 化合物 TN4437	129314-37-0	98%
TN4437	Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
TN1347	8-Prenylkaempferol 化合物8-Prenylkaempferol	28610-31-3	98%
TN1347	8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN3298	8alpha-Hydroxyhirsutinolide 化合物 TN3298	1394156-45-6	98%
TN3298	8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-ÎºB activity with the IC(50) value of 1.9 uM.
TN2177	Sanggenol L 桑根醇L	329319-20-2	98%
TN2177	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apopto...
TN2178	Sanggenone H 桑根酮H	86450-80-8	98%
TN2178	Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α² and inhibited the NF-κB nuclear translocation in LPS-stimulated m...
TN2327	Zedoarondiol 化合物Zedoarondiol	98644-24-7	98%
TN2327	Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
T72869	IMD-biphenylA 化合物 IMD-biphenylA	2928463-40-3	98%
T72869	IMD-biphenylA是NF-κB免疫调节二聚体中的新型咪唑喹啉酮类化合物，具有增强小分子免疫增强剂免疫佐剂性的能力。
T72870	IMD-biphenylB 化合物 IMD-biphenylB	2928463-41-4	98%
T72870	IMD-biphenylB作为NF-κB免疫调节剂二聚体，具有抑制肿瘤增殖的功能，并能诱导低全身炎症反应，同时减少佐剂毒性。