NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product Name	CAS No.	Purity
T72871	IMD-biphenylC 化合物 IMD-biphenylC	2928463-42-5	98%
T72871	IMD-biphenylC是一款新型NF-κB免疫调节剂二聚体，能够有效抑制肿瘤增殖，并诱导较低的全身性炎症反应，同时减轻佐剂的毒性。
T72926	IMD-vanillin 化合物 IMD-vanillin	2928463-38-9	98%
T72926	IMD-vanillin是一新型的咪唑喹啉酮类化合物，作为NF-κB途径的免疫调节二聚体。
T72927	IMD-catechol 化合物 IMD-catechol	2928463-39-0	98%
T72927	IMD-catechol为一种创新的NF-κB免疫调节剂二聚体，能够增强CT26小鼠结肠癌模型的疗效，同时降低辅助毒性至最低。
T74799	NF-κB-IN-8 化合物 NF-κB-IN-8	2924565-59-1	98%
T74799	NF-κB-IN-8 是一种化合物，其作用机制为竞争性抑制 LPS 与 MD-2 之间的相互作用。该化合物通过与 MD-2 结合，有效降低炎症因子的产生，并能够抑制 ALP 的酶活性。因此，NF-κB-IN-8 在急性肺损伤（ALI）等炎症性疾病的研究中具有潜在应用价值。
TN4683	Nyasol 化合物 TN4683	96895-25-9	98%
TN4683	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN2163	Rubioncolin C 钩毛茜草素 C	132242-52-5	98%
TN2163	Rubioncolin C shows good cytotoxicity with IC50 value of 1.53 μM and NF-κB inhibitory activity with IC50 value of 2.97 μM.
TN5250	Vomifoliol 化合物 TN5250	23526-45-6	98%
TN5250	Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major ...
TN1832	Kanzonol C 化合物Kanzonol C	151135-82-9	98%
TN1832	Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sho...
TN1009	Epimagnolin B 表木兰脂素 B	1134188-26-3	98%
TN1009	Epimagnolin B 是一种双环氧木质素，分离自木兰中。它能够抑制 LPS 激活的小胶质细胞中 NO 的产生。它具有抗过敏以及抗炎作用。
TN2588	11-Hydroxytephrosin 化合物 TN2588	72458-85-6	98%
TN2588	11-Hydroxytephrosin inhibits NF-kappaB activity.
TN1212	2-Hydroxyeupatolide 2ALPHA-羟基泽兰内酯	72229-33-5	98%
TN1212	2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and m...
TN4064	Flavoglaucin 化合物 TN4064	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN4094	Gallocatechin gallate 化合物 TN4094	5127-64-0	98%
TN4094	Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN3397	Alpinumisoflavone 化合物 TN3397	34086-50-5	98%
TN3397	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 5-羟基-7,8-二甲氧基黄烷酮	113981-49-0	98%
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的，具有抗炎活性。
TN1793	Isorhamnetin 3-O-galactoside 异鼠李素-3-O-半乳糖苷	6743-92-6	98%
TN1793	Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN4489	Manassantin A 化合物 TN4489	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN4956	Scandoside 化合物 TN4956	18842-99-4	98%
TN4956	Scandoside exerts anti-inflammatory effect via suppressing NF-ÎºB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation...
TN5149	Tirotundin 化合物 TN5149	56377-67-4	98%
TN5149	Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activati...
TN4286	Isodunnianol 化合物 TN4286	139726-30-0	98%
TN4286	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...