NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Cat. No.	Product Name	CAS No.	Purity
TN3537	Braylin 化合物 TN3537	6054-10-0	98%
TN3537	Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
TN3539	Broussonin A 化合物 TN3539	73731-87-0	98%
TN3539	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN1104	Cyanidin 3-sambubioside chloride 矢车菊素-3-桑布双糖苷	33012-73-6	98%
TN1104	Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
TN3839	Desoxo-narchinol A 化合物 TN3839	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TMA1890	Icariside F2 淫羊藿次苷F2	115009-57-9	98%
TMA1890	Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-ÎºB inhibitory effects, wit...
TN1598	Dunnianol 红花八角醇	139726-29-7	98%
TN1598	Dunnianol 显示出抗炎活性和适度的抗菌活性。
T12828	Salicortin 特里杨甙	1887055-63-1	98%
T12828	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity...
TN1484	Cheilanthifoline 碎叶紫堇碱	483-44-3	98%
TN1484	Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation o...
TN2775	2-Methoxystypandrone 化合物 TN2775	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 6,4'-二羟基-7-甲氧基二氢黄酮	189689-32-5	98%
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物，具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的...
TN4604	Myricanone 化合物 TN4604	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN3620	Celaphanol A 化合物 TN3620	244204-40-8	98%
TN3620	Celaphanol A shows moderate inhibition in both NF-ÎºB activation and nitric oxide production, suggests that it is a possible inhibitor of the NF-kappaB pathway a...
TN2075	Pimaric acid 海松酸	127-27-5	98%
TN2075	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human ...
TN4420	Latifolin 化合物 TN4420	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN4490	Manassantin B 化合物 TN4490	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
TN3922	Effusanin E 化合物 TN3922	76470-15-0	98%
TN3922	Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN4213	Hirsutenone 化合物 TN4213	41137-87-5	98%
TN4213	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN5019	Siegeskaurolic acid 化合物Siegeskaurolic acid	52645-97-3	98%
TN5019	Siegeskaurolic acid 是一种具有抗炎活性的天然产物。
TN4194	Heliangin 化合物 TN4194	13323-48-3	98%
TN4194	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells...
TN1834	Kobusin 自旋七叶素	36150-23-9	98%
TN1834	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammat...