PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat. No.	Product Name	CAS No.	Purity
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol 化合物 TN2844	126253-41-6	98%
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
TN2799	20-Deoxyingenol 3-angelate 化合物 TN2799	75567-38-3	98%
TN2799	20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant pl...
T14328	AS2521780 化合物 T14328	1214726-89-2	98%
T14328	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
T17299	(-)-Indolactam V 化合物 T17299	90365-57-4	98%
T17299	(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-...
T16526	Phorbol 12,13-dibutyrate 化合物 T16526	37558-16-0	98%
T16526	Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
T21260	Psychosine 鞘氨醇半乳糖苷	2238-90-6	98%
T21260	Psychosine (Galactosylsphingosine) 是一种 PKC 抑制剂，是半乳糖脑苷脂酶 (GALC) 酶的底物，是 Krabbe 病的潜在生物标志物。Psychosine 具有很强的细胞毒性，可诱导多种细胞死亡。
T15637	K-252b 化合物 T15637	99570-78-2	98%
T15637	K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in ...
T15638	K-252c 化合物 T15638	85753-43-1	98%
T15638	K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotry...
T14831	Bryostatin 1 苔藓抑素1	83314-01-6	98%
T14831	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
TN4300	Isojacareubin 化合物 TN4300	50597-93-8	98%
TN4300	Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
T40101	(±)-1,2-Diolein 甘油1,2-二油酸酯	2442-61-7	98%
T40101	(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) 是一种PKC 激活剂，可以增加肌小管 Ca2+内流。
T13384	Y-33075 化合物 T13384	199433-58-4	98%
T13384	Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
T16848	SB-218078 化合物 T16848	135897-06-2	98%
T16848	SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
T10555	BJE6-106 化合物 T10555	1564249-38-2	98%
T10555	BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-depende...
TN4431	Leucosceptoside A 米团花苷A	83529-62-8	98%
TN4431	Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidas...
TN3517	Bisacurone 化合物 TN3517	120681-81-4	98%
TN3517	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
T13605	Cercosporin 尾孢菌素	35082-49-6	98%
T13605	Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelengt...
TN4271	Isochamaejasmine 异狼毒素	93859-63-3	98%
TN4271	Isochamaejasmine 分离自 S. chamaejasme L. 中分离出来，可抑制 NF-κB 活化。 Isochamaejasmine 通过抑制 Bcl-2 家族蛋白的活性诱导白血病细胞凋亡，可用于抗癌研究。
T16671	PS315 化合物 T16671	1221964-50-6	98%
T16671	PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative ...
TN3655	Cimiside E 化合物 TN3655	154822-57-8	98%
TN3655	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...