HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product Name	CAS No.	Purity
TN4160	Goniothalamin 化合物Goniothalamin	17303-67-2	98%
TN4160	Goniothalamin 在各种癌细胞系中诱导细胞凋亡并具有胃保护活性。
TN4604	Myricanone 化合物 TN4604	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T6804	Chetomin 化合物Chetomin	1403-36-7	98%
T6804	Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T11355	Gamitrinib TPP 化合物 T11355	1131626-46-4	98%
T11355	Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor exhibiting potent anti-cancer activity. Additionally, Gamitrinib TPP functions as a mitochondrial matr...
T6442	CH5138303 化合物CH5138303	959763-06-5	98%
T6442	CH5138303 是一种可口服的 Hsp90 抑制剂，Kd 为 0.48 nM。
TN3070	4beta-Hydroxywithanolide E 化合物 TN3070	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T11356	Gamitrinib TPP hexafluorophosphate 化合物 T11356	1131626-47-5	98%
T11356	Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functio...
T15671	KU-32 化合物 T15671	956498-70-7	98%
T15671	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
T16719	Radicicol 根赤壳菌素	12772-57-5	98%
T16719	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: ...
T5008	Teprenone 替普瑞酮	6809-52-5	99.96%
T5008	Teprenone (Geranylgeranylacetone) 是一种热休克蛋白诱导剂，有抗溃疡作用。
T6305	SNX2112 化合物SNX2112	908112-43-6	99.95%
T6305	SNX2112 (PF 04928473) 是一种具有口服活性的 Hsp90 抑制剂，Kd 为 16 nM。
T2309	Ganetespib 化合物Ganetespib	888216-25-9	99.95%
T2309	Ganetespib (STA-9090) 是一种热休克蛋白 90 抑制剂，通过抑制 HIF-1α 和 STAT3 对大肠癌具有抗血管生成作用。它还具有细胞毒性。
T6297	Alvespimycin hydrochloride 阿螺旋霉素盐酸盐	467214-21-7	99.94%
T6297	Alvespimycin hydrochloride (BMS 826476) 是一种Hsp90抑制剂，结合到 Hsp90，EC50为 62±29 nM。
T3454	VER-49009 化合物VER-49009	558640-51-0	99.93%
T3454	VER-49009 (CCT 129397) 是一种有效的 Hsp90 抑制剂，IC50值为 25 nM，Kd 值为 78 nM。
T13554	Arimoclomol maleate 化合物Arimoclomol maleate	289893-26-1	99.9%
T13554	Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 Hsp 表达来保护运动神经元，进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除
T39321	CC-99677 化合物CC-99677	1887069-10-4	99.87%
T39321	CC-99677 (Gamcemetinib) 是一种一种用于自身免疫性疾病的选择性靶向共价MAPKAPK2(MK2)抑制剂，通过亲核芳族取代(SNAr)机制将生化效力转化为LPS活化的单核细胞THP-27细胞中热休克蛋白27(HSP1)磷酸化的有效抑制所显示的细胞效力。CC-99677 在大鼠实验中展现出在生化(IC ...
T2908	Palmitic acid 棕榈酸	57-10-3	99.87%
T2908	Palmitic acid (Cetylic acid) 属于天然产物，是一种常见的饱和脂肪酸，在动物、植物和微生物中均存在。Palmitic acid 具有抗肿瘤活性。
T28824	SNX0723 化合物SNX0723	1073969-18-2	99.86%
T28824	SNX0723 是一种 Hsp90 抑制剂，具有抗疟原虫活性。SNX0723 对 HsHsp90 和 PfHsp90 具有高结合亲和力，Ki 分别为 4.4 和 47 nM。SNX0723 抑制肝期伯氏疟原虫 ANKA 寄生虫，EC50 为 3.3 μM。
T2258	VER-50589 化合物VER50589	747413-08-7	99.85%
T2258	VER-50589 是一种 Hsp90抑制剂，Kd 值为 4.5 nM，IC50值为 21 nM。
T6284	Onalespib 化合物Onalespib	912999-49-6	99.82%
T6284	Onalespib (AT13387) 是一种合成的、口服生物可利用的热休克蛋白 90 (Hsp90) 小分子抑制剂，Kd 值为 0.71 nM。具有潜在的抗肿瘤活性。它选择性地与 Hsp90 结合，从而抑制其伴侣功能并促进参与肿瘤细胞增殖和存活的致癌信号蛋白的降解。