46
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T33626 |
Nelipepimut-S
NeuVax vaccine,E75 peptide,NeuVax |
||
Nelipepimut-S, as an immunogenic peptide from the HER2 protein, is highly expressed in breast cancer. | |||
T9520 |
ALC-0159
|
Others | Others |
ALC-0159 是聚乙二醇的脂质结合物,是一种疫苗赋形剂。 | |||
T20293 |
Phenoxyethanol
NSC 1864,乙二醇苯醚,NSC-1864,NSC1864 |
Others; Antibacterial | Microbiology/Virology; Others |
Phenoxyethanol (NSC-1864) 是广谱抗菌剂,被用作化妆品、疫苗和纺织品中的防腐剂。它是呼吸作用氧化磷酸化的解偶联剂,竞争性地抑制苹果酸脱氢酶。 | |||
TP1938 |
RS 09
|
TLR | Immunology/Inflammation |
RS 09 是一种 LPS 肽模拟物,是 TLR4 激动剂佐剂,可在疫苗环境中增加抗体产量。 | |||
T4027 |
KIN1148
|
Influenza Virus | Microbiology/Virology |
KIN1148 是一种新型小分子佐剂,是IRF3激动剂,用于增强流感疫苗效率。 | |||
T14513 |
BBIQ
|
TLR | Immunology/Inflammation |
BBIQ 是一种有效且选择性的 toll 样受体 7 (TLR7) 激动剂,对人 TLR7 的 EC50 为 59.1 nM。BBIQ 还是一种功能强大的疫苗佐剂,可增强机体的先天免疫应答。 | |||
T8886 |
NITD-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂,可抑制 DENV RdRp 介导的 RNA 延伸。 | |||
T9277 |
ALC-0315
|
||
ALC-0315是一种可电离的氨基脂质,已与其他脂质组合用于形成脂质纳米颗粒。脂质纳米颗粒已经用于 mRNA (COVID-19) 疫苗的研究。 | |||
T35941 |
DC-Chol hydrochloride
Cholesteryl 3β-N-(dimethylaminoethyl)carbamate hydrochloride,DC-Chol (hydrochloride),DC-Cholesterol hydrochloride,Cholesteryl 3β-N-(dimethylaminoethyl)carbamate |
Beta Amyloid | Neuroscience |
DC-Chol hydrochloride(DC-Cholesterol hydrochloride) 在适当的实验条件下能抑制 Aβ40 纤维的形成且以剂量依赖性的方式显著抑制氧化hCT的淀粉样蛋白形成。DC-Chol hydrochloride可诱导改善和平衡的免疫力,能够促进乙型肝炎疫苗的研究。 | |||
TP1166 |
ZINC77292789
Fmoc-Thr[GalNAc(Ac)3-α-D]-OH,Fmoc-Thr(Ac₃AcNH-α-Gal)-OH |
Others | Others |
ZINC77292789 (Fmoc-Thr[GalNAc(Ac)3-α-D]-OH) 是制备基于三聚体 MUC1 免疫显性基序抗原的候选抗癌疫苗的起始材料,可制备含有 βGalNAc-Thr 作为 Tn 抗原异构体的合成 MUC1 糖肽,可诱导针对肿瘤细胞的抗体产生。 | |||
T19590 |
Trehalose 6-behenate
|
Others | Others |
Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant. | |||
TP2380 |
Elpamotide
|
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Elpamotide is a vaccine consisting of a VEGFR2-169 peptide. | |||
T38550 |
Onilcamotide
|
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Onilcamotide, a cancer vaccine derived from the C-terminal peptide of the RhoC protein, exhibits potential immunomodulating and antineoplastic activities. | |||
T82462 |
Enterotoxin STp (E. coli)
|
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Enterotoxin STp (E. coli), 热稳定肠毒素,适用于疫苗研究领域。 | |||
T38567 |
STh
|
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STh, also known as Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide containing three disulfide bridges. It serves as an antigen of significance in the quest for a comprehensive enterotoxigenic Escherichia coli (ETEC) vaccine. | |||
T38619 |
GSK1795091
CRX-601 |
||
GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines. | |||
T19410 |
M2e, human
|
Others | Others |
M2e, human, a vaccine candidate for human influenza A, encompasses the 23 extracellular residues of M2 (the third integral membrane protein of influenza A) and exhibits remarkable conservation across all strains, highlighting its potential as a broadly protective option. | |||
T75270 |
Genevant CL1
|
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Genevant CL1 是一种脂质,可用于 mRNA 脂质纳米颗粒 (LNP) 疫苗递送。 | |||
T81645 |
NPNA hexamer
|
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NPNA hexamer是一种与疟疾研究和孢子疫苗开发相关的肽。 | |||
T82930 |
Autoinducing Peptide I
|
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Autoinducing Peptide I为金黄色葡萄球菌分泌的环状八肽,主要用于疫苗研究领域。 | |||
T38636 |
Monophosphoryl lipid A
Glucopyranosyl lipid A |
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Monophosphoryl lipid A (MPLA), also known as Glucopyranosyl lipid A, is an agonist of toll-like receptor 4. Derived from the cell wall of nonpathogenic Salmonella, MPLA is a valuable compound for research on immunization and vaccine development. | |||
T72016 |
ST101036
|
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MC activators have recently been described as safe and effective vaccine adjuvants. ST101036 exhibited high degranulation potency in both human and mouse MCs. | |||
T38936 |
KRAS G13D peptide, 25 mer
KRAS G13D peptide, 25 mer |
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KRAS G13D peptide, a 25-mer sequence, is derived from the KRAS activating oncogene mutation and serves as an immune potentiator. This peptide possesses immunogenic properties and can be utilized for the development of a KRAS vaccine. | |||
T72688 |
STING agonist-20
|
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STINGagonist-20 是一种有效的STING 激动剂,用于合成 XMT-2056。STINGagonist-20 可作为疫苗佐剂,用于癌症以及其他炎症,免疫性疾病的研究。 | |||
T82048 |
IRGRILHDGAYSLTLQGLGIH
|
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IRGRILHDGAYSLTLQGLGIH是一种针对大鼠HER2/neu的多表位II类肽。它主要应用于HER2-DC1疫苗的II类研究领域。 | |||
T83224 |
AADvac 1
|
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AADvac1 是一款针对Tau(294–305)的阿尔茨海默病肽疫苗,其通过与KLH缀合,表现出生物活性。 | |||
T75027 |
G0-C14
|
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G0-C14,一种阳离子类脂烷基修饰的聚氨基胺(PAMAM)树状大分子,适用于巨噬细胞靶向纳米颗粒(NPs)系列的制备,并可用于活性分子与疫苗递送。 | |||
T81112 |
SPPHPSPAFSPAFDNLYYWDQ
|
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SPPHPSPAFSPAFDNLYYWDQ 为多表位 II 类大鼠HER2/neu 肽,适用于 HER2-DC1 II 类疫苗研究。 | |||
T81111 |
SPPHPSPAFSPAFDNLYYWDQ TFA
|
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SPPHPSPAFSPAFDNLYYWDQ TFA,一种II类大鼠HER2/neu多表位肽,应用于II类HER2-DC1疫苗的研究。 | |||
T74916 | ODN M362 | ||
ODN M362 是一种 C 类寡核苷酸,是 TLR-9激动剂,可用作疫苗佐剂。ODN M362 诱导癌细胞凋亡(apoptosis)。 | |||
T74902 |
ODN 1018
|
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ODN 1018 (1018 ISS)为一种寡脱氧核苷酸,兼具TLR-9激动剂与合成免疫刺激序列的特性,广泛应用作疫苗佐剂。序列为5′-TGACTGTGAACGTTCGAGATGA-3′。 | |||
T74909 |
ODN 2395
|
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ODN 2395为C类寡核苷酸,作为疫苗佐剂和TLR9激动剂应用。其序列为5'-tcgtcgttttcggcgc:gcgccg-3'。(注:碱基为硫代磷,ODN 2395特征为包含部分回文序列cggcgc:gcgccg) | |||
T74315 |
16:0 EPC chloride
|
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16:0 EPC chloride,一种P-O-乙基衍生的饱和阳离子脂质,可用作DNA与RNA转染剂,亦作为疫苗制备及促进药物递送的辅助佐剂。 | |||
T74903 |
ODN 1668
|
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ODN 1668,一种B类CpG ODN(寡脱氧核苷酸),作为TLR-9激动剂,充当免疫刺激序列并可用作疫苗佐剂。序列为5’-tccatgacgttcctgatgct-3’。 | |||
T74908 |
ODN 2336
|
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ODN 2336 是 A 类 CpG ODN(寡脱氧核苷酸),是一种有效的 TLR9激动剂。ODN 2336 诱导 IFN-α 的产生。ODN 2336 上调 IP-10 mRNA 和 IL-18mRNA 的表达。ODN 2336 可用作疫苗的佐剂。 | |||
T74910 | ODN 24888 | ||
ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN),对TLR7/TLR9介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和NF-κB 激活,抑制IL-6的释放。ODN 24888 参与免疫和炎症应答,可作为疫苗佐剂使用。 | |||
T74905 |
ODN 2007
|
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ODN 2007是一种B类CpG ODN(寡脱氧核苷酸),兼具Toll样受体(TLR)配体功能。作为免疫调节剂和疫苗佐剂,它能够增强哺乳动物、鱼类及人类的免疫反应。其序列为5'-TCGTCGTTGTCGTTTTGTCGTT-3'。 | |||
T79707 |
Cholicamideβ
|
Necroptosis | Apoptosis |
Cholicamideβ(compound 6)为自组装小分子癌症疫苗佐剂,能够形成细胞毒性低的病毒样颗粒。该化合物与肽抗原结合,可增强树突状细胞的抗原呈递能力,并激活抗原特异性T细胞反应。Cholicamideβ还能引发细胞凋亡(apoptosis)和坏死(necrosis)。 | |||
T81388 |
Propiolactone
Betaprone,β-propiolactone,2-Oxetanone |
SARS-CoV | Microbiology/Virology |
Propiolactone (β-propiolactone; 2-Oxetanone) 作为一种病毒化学灭活剂,能够使病毒失去传染性。以1:1000 (v:v) 的比例与SARS-CoV共孵育,Propiolactone可用于制备流感病毒疫苗中的抑菌剂(Flu-BPL)。 | |||
T76016 |
M2e, human TFA
|
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M2e, human TFA 由 23 个 M2 (流感病毒A 的第三个完整膜蛋白) 胞外残基组成,在所有人流感病毒 A 株中都有显著的保守性。M2e, human TFA 是一种有效且多用途的疫苗候选,可预防人类流感病毒 A 株。 | |||
T74326 | αGalCer-RBD | ||
αGalCer-RBD 是一种佐剂脂蛋白结合物。αGalCer-RBD 可诱导对 SARS-CoV-2及其变异毒株的有效免疫。αGalCer-RBD 结合物诱导 RBD 特异性、产生细胞因子的 T 细胞发育。αGalCer-RBD 有望成为一种有效的 COVID-19 疫苗候选化合物。α-Galactosylceramide (αGalCer) 是一种有效的不变自然杀伤 T 细胞 (iNKT) 激动剂。 | |||
T64277 |
ODN 1585
|
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ODN 1585 是一种有效的 IFN 和 TNFα 产生诱导剂,也是一种 NK (natural killer) 的有效刺激剂,可用做疫苗佐剂。ODN 1585 能够增强 CD8+ T 细胞的功能,包括 CD8+ T 细胞介导的 IFN-γ 的产生。ODN 1585 可以诱导小鼠已建立的黑色素瘤消退,对小鼠的疟疾也表现出完全的保护作用。ODN 1585 能够用于研究急性骨髓性白血病 (AML) 和疟疾。 | |||
T75102 | COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP) | ||
COVID-19 Spike Protein mRNA 用于表达新型冠状病毒肺炎刺突蛋白,关键于 RNA 传递、翻译效率与细胞活力的检测。该蛋白定位于病毒膜表面,主导病毒与宿主细胞膜受体的结合及膜融合,促使 COVID-19 病毒入侵细胞。同时,它是宿主中和抗体作用的主要位点与疫苗开发的核心靶标。 | |||
T74052 |
Polyinosinic-polycytidylic acid potassium
|
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Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) 是双链 RNA 的合成类似物,是一种TLR3和视黄酸诱导型基因 I 受体 (RIG-I 和MDA5) 的激动剂。Polyinosinic-polycytidylic acid potassium 可以用作疫苗佐剂,以增强先天性和适应性免疫反应,并改变肿瘤的微环境,还可以直接触发癌细胞发生凋亡 (Apoptosis)。 | |||
T75116 | COVID-19 Spike Protein mRNA-LNP | ||
COVID-19 Spike Protein mRNA-LNP 是一种RNA传递系统,利用脂质纳米粒(LNP)封装COVID-19 Spike Protein mRNA,提高翻译效率与细胞活性。COVID-19 Spike Protein,位于新冠病毒膜表面,负责与宿主细胞受体结合和膜融合,是病毒进入细胞的关键因素,同时也是疫苗设计与宿主中和抗体生成的核心靶点。 | |||
T74067 |
Poly (I:C):Kanamycin (1:1) (sodium)
|
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Poly (I:C):Kanamycin (1:1) sodium 是 Poly (I:C) 和 Kanamycin 的等比例复合物。Poly(I:C) sodium 是双链 RNA 的合成类似物,是一种TLR3和视黄酸诱导型基因 I 受体 (RIG-I 和MDA5) 的激动剂。Poly(I:C) sodium 可以用作疫苗佐剂,增强先天性和适应性免疫反应,并诱导癌细胞凋亡。Kanamycin 是一种具有口服活性的抗菌剂(革兰氏阴性/阳性细菌),可抑制易位并通过与 70 S 核糖体亚基结合引起错误编码。Kanamycin 对结核分枝杆菌(敏感和耐药)和肺炎克雷伯菌均表现出良好的抑制活性,可用于结核病和肺炎的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2232 |
Soyasaponin Ab
|
NOS; NF-κB; COX | Immunology/Inflammation; Neuroscience; NF-κB |
Soyasaponin Ab 是一种大豆皂苷。Soyasaponin Ab 在 3T3-L1 脂肪细胞中通过下调 PPARγ 产生抗肥胖的作用。 | |||
TN2230 |
Soyasaponin Ba
大豆皂苷 BA,大豆皂苷Ba |
Others | Others |
Soyasaponin Ba 是一种大豆皂苷,分离自菜豆类,可用作醛糖还原酶抑制剂。 | |||
TN4804 |
Platycoside A
|
Antifection | Microbiology/Virology |
Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice. | |||
T38838 |
QS-21
Stimulon,QS-21 |
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QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
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9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... |