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Search Results for " unfolded protein response "

18

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4304	Azoramide	Apoptosis; PERK	Apoptosis
	Azoramide 是一种小分子调节剂，具有未折叠蛋白反应的抗糖尿病活性。
T8464	RA-9	Apoptosis; DUB	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	RA-9 是一种高选择性蛋白酶体相关的 DUBs 抑制剂，具有良好的毒性和抗癌活性。它阻断泛素依赖性蛋白降解而不影响 20S 蛋白酶体蛋白水解活性。它诱导卵巢癌细胞内质网应激反应，选择性诱导卵巢癌细胞株和供体原代培养细胞凋亡。
T9110	Ceapin-A7	Others	Others
	Ceapin-A7 是内质网应激 ATF6α信号的选择性阻断剂(IC50:0.59 μM)，可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。
T9349	IXA4	IRE1	Cell Cycle/Checkpoint
	IXA4 是一种高选择性、无毒的 IRE1/XBP1s 激活剂，通过激活 IRE1 来减少 APP 的分泌。它刺激的 IRE1 激活也增强了胰腺功能。
T39980	ErSO	Others	Others
	ErSO 是一种通过 ERα 受体的，预期未折叠蛋白反应 (UPR) 的特异性激活剂。 ErSO 可用于抗癌研究。
T10706	CCI-006	Mitochondrial Metabolism	Metabolism
	CCI-006 是一种 MLL 重排白血病细胞的选择性抑制剂和化学增敏剂。它能够抑制线粒体呼吸，造成 MLL-r 白血病细胞亚群中无法克服的线粒体去极化和促凋亡未折叠蛋白反应。
T14080	AA147 ATF6-activator-147	Others	Others
	AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂，能够选择性激活未折叠蛋白反应的 ATF6臂。
T24928	UPR-IN-17# UPR inhibitor-17#,UPR IN 17#,UPR inhibitor 17#
	UPR-IN-17# is an effective pan-inhibitor of the unfolded protein response.
T39981	(±)-ErSO
	(±)-ErSO is the racemic form of ErSO. ErSO is a selective anticipatory activator of the unfolded protein response (a-UPR).
T10102	3,6-DMAD hydrochloride	Others	Others
	3,6-DMAD hydrochloride is an inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response.
T64231	3,6-DMAD hydrochloride
	3,6-DMAD hydrochloride 是一种未折叠蛋白质应答 (IRE1α-XBP1) 通路的抑制剂。
T71151	Z36
	Z36 is a novel Bcl-xL inhibitor, upregulating the expression levels of FAM134B, LC3, and Atg9, inducing autophagy along with autophagic cell death, resulting in ER stress and the unfolded protein response (UPR).
T22104	ML-291
	ML291 is a sufonamidebenzamide compound that induces the unfolded protein response (UPR) and overwhelms the adaptive capacity of UPR, resulting in apoptosis in various solid cancer models. It activates the PERK/eIF2a/CHOP apoptotic pathway of UPR and reduces leukemic cell burden [1].
T14553	BHPI	Others	Others
	BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression. Elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis.
T62108	ErSO-DFP
	ErSO-DFP 是一种预期的未折叠蛋白反应 (a-UPR) 激活剂。ErSO-DFP 能够提高对雌激素受体α+ (ERα+) 癌细胞的选择性，选择性高于 ErSO。ErSO-DFP 具有抗肿瘤作用，能够明显消除小鼠模型中 MCF-7 肿瘤。
T79062	IRE1α kinase-IN-8	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-8，作为苯并杂环甲醛衍生物，是一种高效的IRE-1α抑制剂，主要用于研究未折叠蛋白反应或受调节的IRE1依赖性衰减(RIDD)相关疾病。
T79063	IRE1α kinase-IN-9	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-9（compound 2）为一种有效IRE-1α抑制剂，其平均IC50值小于0.1 μM。该化合物适用于探究未折叠蛋白反应（UPR）及调控IRE1依赖性衰减（RIDD）相关疾病的研究。
T72543	BOLD-100 free base NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base
	BOLD-100 (NKP-1339; IT-139) free base 是一款钌基抗癌药物。作为GRP78应激诱导上调的抑制剂，它破坏内质网(ER)的稳态，从而诱发ER应激和未折叠蛋白反应(UPR)。此外，BOLD-100 free base 干预了内质网应激反应、溶酶体动力学以及细胞自噬(autophagy)间的复杂交互作用。

化合物

Cat.No: T4304

Target: Apoptosis, PERK

Cat.No: T8464

Target: Apoptosis, DUB

Cat.No: T9110

Target: Others

Cat.No: T9349

Target: IRE1

Cat.No: T39980

Target: Others

Cat.No: T10706

Target: Mitochondrial Metabolism

Cat.No: T14080

Synonym: ATF6-activator-147

Target: Others

Cat.No: T24928

Synonym: UPR inhibitor-17#,UPR IN 17#,UPR inhibitor 17#

Cat.No: T39981

3,6-DMAD hydrochloride

Cat.No: T10102

Target: Others

3,6-DMAD hydrochloride

Cat.No: T64231

Cat.No: T71151

Cat.No: T22104

Cat.No: T14553

Target: Others

Cat.No: T62108

IRE1α kinase-IN-8

Cat.No: T79062

Target: IRE1

IRE1α kinase-IN-9

Cat.No: T79063

Target: IRE1

BOLD-100 free base

Cat.No: T72543

Synonym: NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base

Cat. No.	Product Name	Target	Signaling Pathways
TQ0302	Thapsigargin 毒胡萝卜素	Apoptosis; SARS-CoV; Calcium Channel	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Thapsigargin 属于天然产物，是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂，也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: TQ0302

Synonym: 毒胡萝卜素

Target: Apoptosis, SARS-CoV, Calcium Channel

Cat.No: T36954

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