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Search Results for " trauma "

17

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4065	Fluorescein Sodium 荧光素钠,Fluorescite,VST-1001,Acid yellow 73,VST1001,VST 1001	Others	Others
	Fluorescein Sodium (VST-1001) 是一种具有代表性的绿色荧光示踪剂，广泛用于医学、生物应用和肿瘤感染组织的示踪剂，也可作为实用绿色荧光探针的支架。
T28978	Tirilazad mesylate U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate	Antiviral	Immunology/Inflammation
	Tirilazad mesylate (U 74006F) 是一种非糖皮质激素，是一种脂质过氧化抑制剂，具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化，可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤，抑制狗体内毒素的作用，降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。
T27509	GW-493838 GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X	Adenosine Receptor	GPCR/G Protein; Neuroscience
	GW-493838是一种有效的腺苷 A1A 受体激动剂，用于治疗血脂异常和神经性疼痛，对创伤或手术引起的疱疹后神经痛或周围神经损伤具有镇痛效果。
TP1309	Gastric mucin	Antibacterial; Antibiotic	Microbiology/Virology
	Gastric mucin 是一种能保护胃肠道免受酸、蛋白酶、致病微生物和机械创伤影响的糖蛋白。
T111959	IFB-088 acetate
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T67614	Tranexamic Acid (Random Configuration)
	Tranexamic acid is a medication used to treat or prevent excessive blood loss from major trauma, surgery, tooth removal, nose bleeds, and heavy menstruation.
T11327L	FR 167653 free base	Others	Others
	FR 167653 free base is an orally active p38 MAPK inhibitor and is effective in treating inflammation, relieving trauma, and ischemia-reperfusion injury in vivo. It also is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MA
T40602	Z-LEHD-FMK TFA
	Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, offering protection against detrimental reperfusion injury and moderating apoptosis. Additionally, Z-LEHD-FMK TFA demonstrates its neuroprotective potential in a rat model of spinal cord trauma.
T60435	Propacetamol
	Propacetamol 是可代谢为 paracetamol 的前体药物，是一种镇痛剂，可用于术后疼痛、急性创伤和胃肠道疾病。
T22554	Adenosine Kinase Inhibitor (hydrate)	Others	Others
	Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associa
T61258	HFI-419
	HFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma, and stroke [1].
T11327	FR 167653 FR 167653 sulfate	p38 MAPK	MAPK
	FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR 167653 , an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
T68297	Dilmapimod tosylate
	Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and...
T76372	TRAF6 peptide
	TRAF6 peptide 是一种特异性的TRAF6-p62相互作用抑制剂。TRAF6 peptide 能消除 NGF 依赖性TrkA 泛素化。TRAF6 peptide 在诸如阿尔茨海默症 (AD)、帕金森、ALS、头部外伤、癫痫和中风等神经系统性疾病中具有较好的研究潜力。
T78221	TRAF6 peptide TFA	E1/E2/E3 Enzyme	Ubiquitination
	TRAF6 peptide TFA是一种抑制TRAF6-p62相互作用的特异性分子，可抑制NGF依赖的TrkA泛素化，展现在阿尔茨海默症（AD）、帕金森病、ALS、创伤性脑损伤、癫痫和中风等神经系统疾病研究中的应用潜力。
T78301	Aselizumab HuDreg-55
	Aselizumab (HuDreg-55)是一种针对L-选择素(L-selectin)的人源化IgG4单克隆抗体。L-选择素(CD62L)，作为循环中性粒细胞表面的一种细胞黏附分子，负责调控细胞向受损组织的趋化作用。应用Aselizumab可能会导致患者经历高发感染率及白细胞减少的副作用。
T73989	Tirilazad
	Tirilazad是一种21-氨基类固醇非糖皮质激素，具有抑制脂质过氧化的能力。它对于脑或脊髓中因创伤、中风、缺血再灌注损伤所致的损害有减轻作用。此外，Tirilazad还展现出针对新型肺炎病毒的抗病毒活性，并在缺血性中风中提供神经保护，适用于蛛网膜下腔出血研究场景。

化合物

Fluorescein Sodium

Cat.No: T4065

Synonym: 荧光素钠,Fluorescite,VST-1001,Acid yellow 73,VST1001,VST 1001

Target: Others

Tirilazad mesylate

Cat.No: T28978

Synonym: U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate

Target: Antiviral

Cat.No: T27509

Synonym: GW 493838X,GW 493838,GW493838,GW493838X,GW-493838X

Target: Adenosine Receptor

Cat.No: TP1309

Target: Antibacterial, Antibiotic

IFB-088 acetate

Cat.No: T111959

Tranexamic Acid (Random Configuration)

Cat.No: T67614

FR 167653 free base

Cat.No: T11327L

Target: Others

Cat.No: T40602

Cat.No: T60435

Adenosine Kinase Inhibitor (hydrate)

Cat.No: T22554

Target: Others

Cat.No: T61258

Cat.No: T11327

Synonym: FR 167653 sulfate

Target: p38 MAPK

Dilmapimod tosylate

Cat.No: T68297

Cat.No: T76372

TRAF6 peptide TFA

Cat.No: T78221

Target: E1/E2/E3 Enzyme

Cat.No: T78301

Synonym: HuDreg-55

Cat.No: T73989

Cat. No.	Product Name	Target	Signaling Pathways
T5145	Oxytocin acetate Oxytocic hormone acetate,α-Hypophamine acetate,Oxytocin acetate (50-56-6 free base),醋酸催产素	Oxytocin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Oxytocin acetate (α-Hypophamine acetate) 是哺乳动物的神经垂体激素，是多效的下丘脑肽，是催产素受体的配体，有助于分娩、哺乳和亲社会行为。它可作为一种压力应对分子，具有抗炎、抗氧化剂和保护作用。
T4454	Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid	Antioxidant	oxidation-reduction
	Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸，从菜豆中分离得到。它可减少膜磷脂的过氧化，并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。
T3O2749	L-Leucine (S)-Leucine,Leu,L-亮氨酸,亮氨酸	mTOR	PI3K/Akt/mTOR signaling
	L-Leucine ((S)-Leucine) 是必需的支链氨基酸，能够激活 mTOR 信号通路。
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
T32326	Juvabione
	Juvabione is the methyl ester of todomatuic acid, both of which are sesquiterpenes (C15) found in the wood of true firs of the genus Abies. They exist as part of a mixture of sesquiterpenes based on the bisabolane scaffold. Sesquiterpenes of this family,

天然产物

Oxytocin acetate

Cat.No: T5145

Synonym: Oxytocic hormone acetate,α-Hypophamine acetate,Oxytocin acetate (50-56-6 free base),醋酸催产素

Target: Oxytocin Receptor

Traumatic Acid

Cat.No: T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid

Target: Antioxidant

Cat.No: T3O2749

Synonym: (S)-Leucine,Leu,L-亮氨酸,亮氨酸

Target: mTOR

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Cat.No: T32326

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