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17

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1473	Trilostane 曲洛斯坦,Win 24540,曲洛司坦	Dehydrogenase	Metabolism
	Trilostane (Win 24540) 是一种3 β-羟化类固醇脱氢酶抑制剂，能够作用于库兴氏综合征。
T30808	CG500354 CG-500354,CG 500354
	CG500354 plays a tumor suppressive role through the cAMP/CREB signaling pathway and is a novel inducer of neural differentiation and growth arrest in primary HUMAN GBM derived cells.
T39342	4-Maleimidosalicylic acid
	4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells.
T74010	(Rac)-Mono(3,5,5-trimethylhexyl) phthalate
	(Rac)-Mono(3,5,5-trimethylhexyl) phthalate 为常见邻苯二甲酸酯增塑剂的关键代谢物，具备免疫抑制功能。
T81947	Laxiflorin B-4	ERK	MAPK
	Laxiflorin B-4为改性Laxiflorin B，其对ERK1/2的亲和力更高，具备更强的抗肿瘤活性。
T4134L	OTS514 OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis; TOPK	Apoptosis; MAPK
	OTS514 (OTS514 Hydrochloride) 是一种高效的 TOPK 抑制剂，IC50为 2.6 nM。它强效抑制 TOPK 阳性的肿瘤细胞生长，还可诱导细胞周期停滞和凋亡。
T64004	DX3-234
	DX3-234 是氧化磷酸化 (OXPHOS) 抑制剂。在胰腺癌的 Pan02 同基因模型中，DX3-234 具有明显的肿瘤抑制活性。
T81555	Pancreastatin (33-49), porcine
	Pancreastatin (33-49), porcine，一种来自猪胰腺的肽片段，体外显示出抑制胰岛素的活性，并增强葡萄糖启动作用。
TP1557	Urocortin II, human TFA
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor. Human urocortin II exhibits mild motor-suppressive effects and delayed anxiolytic-like effects，suggesting a time-depen
T73508	FLDP-5
	FLDP-5 为一种可透过血脑屏障的姜黄素类似物，能够诱导活性氧（ROS）产生、DNA损伤及细胞周期S期阻滞。此外，FLDP-5 在抑制LN-18细胞增殖和迁移方面表现出显著的抗肿瘤活性。
T80966	Topsalysin PRX-302
	Topsalysin为PSA激活的前体蛋白质，同时是与人前列腺特异性抗原融合的孔隙形成蛋白（合成原气溶素）。研究显示Topsalysin能够抑制小鼠模型中的肿瘤生长。
T78291	Tregalizumab BT-061
	Tregalizumab为人源化抗CD4单克隆抗体（IgG1型），体外能选择性激活调节性T细胞（Tregs）功能。适用于研究自身免疫性疾病（因Treg功能不足）及过敏反应。
T82711	CKS-17
	CKS-17为一合成逆转录病毒包膜肽，其氨基酸序列高度保守，在多种动物及人类逆转录病毒跨膜包膜蛋白中均可见。作为免疫调节表位，CKS-17展现出对众多免疫功能的抑制作用。
T72909	D-(+)-Sorbose
	D-(+)-Sorbose，一种 D-Sorbose 的活性对映异构体，可抑制双糖酶活性并对大鼠餐后血糖和胰岛素水平有抑制作用。D-Sorbose 作为甜味剂有助于预防相关疾病，如 2 型糖尿病。
T35460	β-Endorphin (rat)
	β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagon...
T35771	Destruxin B2
	Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 ...
T36593	TEI-9648
	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons...

化合物

Cat.No: T1473

Synonym: 曲洛斯坦,Win 24540,曲洛司坦

Target: Dehydrogenase

Cat.No: T30808

Synonym: CG-500354,CG 500354

4-Maleimidosalicylic acid

Cat.No: T39342

(Rac)-Mono(3,5,5-trimethylhexyl) phthalate

Cat.No: T74010

Cat.No: T81947

Target: ERK

Cat.No: T4134L

Synonym: OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514

Target: Apoptosis, TOPK

Cat.No: T64004

Pancreastatin (33-49), porcine

Cat.No: T81555

Urocortin II, human TFA

Cat.No: TP1557

Cat.No: T73508

Cat.No: T80966

Synonym: PRX-302

Cat.No: T78291

Synonym: BT-061

Cat.No: T82711

Cat.No: T72909

β-Endorphin (rat)

Cat.No: T35460

Cat.No: T35771

Cat.No: T36593

Cat. No.	Product Name	Target	Signaling Pathways
T3382	Wilforlide A Abruslactone A,雷公藤内酯甲,3-Epiabruslactone A,Regelide	Tyrosinase	Proteases/Proteasome
	Wilforlide A (3-Epiabruslactone A) 是一种具有生物活性的三萜，从雷公藤中分离得到，具有抗炎和免疫抑制活性。
TN1560	Dehydroeffusol 去氢厄弗酚,5-Ethenyl-1-Methylphenanthrene-2,7-Diol,Dehydro Effusol	MMP; ERK; GPR; Others	Endocrinology/Hormones; GPCR/G Protein; MAPK; Others; Proteases/Proteasome
	Dehydroeffusol (Dehydro Effusol) 通过选择性诱导肿瘤抑制性内质网应激和中度细胞凋亡来抑制胃癌细胞生长和致瘤性，具有抗癌、抗焦虑和镇静作用。
TN3482	Bakkenolide B	NOS; COX	Immunology/Inflammation; Neuroscience
	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN2181	Sarmentosin	Others	Others
	Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum glutamate-pyruvate transaminase.
TN3125	5-Methoxycanthin-6-one	Others	Others
	5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosi

天然产物

Cat.No: T3382

Synonym: Abruslactone A,雷公藤内酯甲,3-Epiabruslactone A,Regelide

Target: Tyrosinase

Cat.No: TN1560

Synonym: 去氢厄弗酚,5-Ethenyl-1-Methylphenanthrene-2,7-Diol,Dehydro Effusol

Target: MMP, ERK, GPR, Others

Cat.No: TN3482

Target: NOS, COX

Cat.No: TN2181

Target: Others

5-Methoxycanthin-6-one

Cat.No: TN3125

Target: Others

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