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4

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1776	Plerixafor 普乐沙福,JM3100,AMD 3100,AMD-3329	Virus Protease; HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Plerixafor (AMD-3329) 是一种趋化因子受体拮抗剂，可阻断基质细胞衍生因子与细胞受体 CXCR4 的结合。它也是 CXCR7 的变构激动剂，是免疫刺激剂和造血干细胞动员剂，还抑制HIV-1和HIV-2的复制，EC50为 1-10 nM。
T3460	HhAntag	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。
T70229	Laromustine
	Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits 06-alkyl-guanine transferase, an enzyme involved with DNA repair.
T37831	CAY10641
	Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from thesn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.1CAY10641 is an inactive alcohol derivative of a highly potent (IC50= 12 nM) cPLA2α inhibitor.2The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in...

化合物

Cat.No: T1776

Synonym: 普乐沙福,JM3100,AMD 3100,AMD-3329

Target: Virus Protease, HIV Protease, CXCR

Cat.No: T3460

Target: Hedgehog/Smoothened, Smo

Cat.No: T70229

Cat.No: T37831

Cat. No.	Product Name	Target	Signaling Pathways
T3836	Eudesmin	MAPK; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Eudesmin 通过抑制S6K1信号通路来干扰成脂分化，具有抗肿瘤、抗炎和抗菌活性。
T6S1740	Nardosinone 苷松新酮,甘松新酮	Others	Others
	Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂，分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具，不仅可用于研究神经生长因子 (NGF) 的作用机理，而且可用于研究神经毒性物质的作用机理。
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol	MAPK; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK
	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.

天然产物

Cat.No: T3836

Target: MAPK, S6 Kinase

Cat.No: T6S1740

Synonym: 苷松新酮,甘松新酮

Target: Others

(2R,3S)-Dihydrodehydroconiferyl alcohol

Cat.No: TN2844

Target: MAPK, PKC

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