首页工具

登录

搜索结果

Search Results for " sphingosine 1-phosphate (s1p) "

25

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T6923	Ozanimod 奥扎莫德,RPC-1063	S1P Receptor; LPL Receptor	GPCR/G Protein
	Ozanimod (RPC-1063) 是一种选择性S1P1和S1P5受体激动剂，在[35S]-GTPγS 结合实验中，EC50分别为 410 pM 和 11 nM。它可研究治疗克罗恩病、溃疡性结肠炎、多发性硬化症和复发性多发性硬化症的试验。
T83910	S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
	S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM)，同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内，S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中，由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平，并且在雌性大鼠中降低了心率。
T27864	LX-2931 LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305	S1P Receptor	GPCR/G Protein
	LX-2931(LX-3305) 是一种鞘氨醇-1-磷酸裂解酶（S1P）抑制剂，可用于治疗类风湿性关节炎。
T22102	ML-178 CYM50179	Others	Others
	ML-178 是一种二氯苯，是鞘氨醇-1-磷酸受体4（S1PR4）的强效选择性激动剂，EC50 为 46 nM，在25 μM 的浓度下对其他 S1P 受体没有影响。
T63047	SLP9101555	S1P Receptor; LPL Receptor	GPCR/G Protein
	SLP9101555 是一种有效且具有选择性的鞘氨醇激酶 2（SphK2）抑制剂，Ki 为90 nM。SLP9101555对SphK2具有很高的亲和力，是 SphK1 的 200 倍。SLP9101555 显著降低细胞外 S1P 鞘氨醇 1- 磷酸（S1P）水平。
T2539	Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德	TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel
	Fingolimod hydrochloride (FTY720) 是一种新型免疫调节剂，是一种 1-磷酸鞘氨醇(S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它诱导 S1P1 的内化，从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化，尤其是被 SK2 磷酸化，从而可与 S1PR1、3、4 和 5 结合
T14924	Cenerimod ACT-334441	S1P Receptor	GPCR/G Protein
	Cenerimod (ACT-334441) 是一种具有口服活性、选择性和高效性的磷酸鞘氨醇 1 受体（S1P1）激动剂（EC50：1 nM）。Cenerimod 对多种 S1P 的亚型具有抑制作用，可用于研究鼠类实验性自身免疫性脑脊髓炎 (EAE)和鼠类硬皮病。
T62552	Ozanimod hydrochloride
	Ozanimod (RPC-1063) hydrochloride 是一种鞘氨醇 1-磷酸 (S1P) 受体调节剂，能够高亲和力地选择性结合 S1P 受体亚型 1 (S1P1) 和 S1P5 (S1P5)。Ozanimod hydrochloride 能够调节 hS1P1 受体 (EC50: 1.03 nM) 和 hS1P5 受体 (EC50: 8.6 nM)。Ozanimod hydrochloride 能够用于研究复发性多发性硬化 (MS)。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T14930	Ceralifimod ONO-4641	Others	Others
	Ceralifimod (ONO-4641) is a potent agonist for sphingosine 1-phosphate receptors 1 and 5 (EC50s: 27.3, 334 pM for human S1P receptor 1 and 5).
T36833	A6770
	A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50= <0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50= <100 μM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
T28838	SPM-242 SPM 242
	SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and lymphocyte trafficking, by activat
T78160	SLB1122168 formic	LPL Receptor	GPCR/G Protein
	SLB1122168 formic为一种高效的Spns2介导的S1P释放抑制剂，其半抑制浓度（IC50）为94 nM。
T37955	Sphingosine-1-phosphate (d16:1) Sphingosine-1-phosphate (d16:1)
	C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.
T70613	SLP120701 HCl
	SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
T10387	ASP1126	Others	Others
	ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3).
T70614	SLR080811 HCl
	SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway has attracted significant attention because alteration of S1P levels is linked to several disease states including cancer, fibrosis, and sickle cell disease.
T70900	VT-ME6
	VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residues in the enzyme binding pocket.13,14 This compound is moderately potent (Ki = 8 lM) and displays three-fold selectivity for SphK2 over SphK1. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK...
T41145	TASP 0277308
	TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) and suppresses angiogenesisin vivo. TASP 0277308 also blocks VEGF-induced tube-formation of HUVECsin vitroand reverses or impairs the development of arthritis or mechano-allodynia.
T71301	Opaganib HCl
	ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a...
T64065	Siponimod hemifumarate
	Siponimod (BAF-312) hemifumarate 是一种选择性的、有效的鞘氨醇 -1- 磷酸 (S1P) 受体调节剂。Siponimod hemifumarate 对 S1P1 受体 (EC50: 0.39 nM) 和 S1P5 受体 (EC50: 0.98 nM) 的选择性高于 S1P2 (EC50>10000 nM)、S1P3 (EC50>1000 nM) 和 S1P4 (EC50: 750 nM) 。Siponimod hemifumarate 能够用于研究多发性硬化症 (MS)。
T37548	azido-FTY720 azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...
T83893	SLB1122168
	SLB1122168是Spns2的抑制剂，针对小鼠转运蛋白的IC50值为94 nM。该化合物在以10 mg/kg的剂量给药时，能降低循环中的淋巴细胞数量，但不影响小鼠的血浆S1P水平。
T38336	W140 (trifluoroacetate salt) W140 (trifluoroacetate salt)
	Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. W140 is an inactive enantiomer of W146, a selective S1P1 antagonist (Ki = 77 nM), that binds to the S1P1 receptor with a Ki of 4.6 μM (2a = W146; 2b = W...
T37187	D-erythro/L-threo Lysosphingomyelin (d18:1) D-erythro/L-threo Lysosphingomyelin (d18:1)
	Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O...

化合物

Cat.No: T6923

Synonym: 奥扎莫德,RPC-1063

Target: S1P Receptor, LPL Receptor

Cat.No: T83910

Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31

Cat.No: T27864

Synonym: LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305

Target: S1P Receptor

Cat.No: T22102

Synonym: CYM50179

Target: Others

Cat.No: T63047

Target: S1P Receptor, LPL Receptor

Fingolimod hydrochloride

Cat.No: T2539

Synonym: Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德

Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor

Cat.No: T14924

Synonym: ACT-334441

Target: S1P Receptor

Ozanimod hydrochloride

Cat.No: T62552

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Cat.No: T14930

Synonym: ONO-4641

Target: Others

Cat.No: T36833

Cat.No: T28838

Synonym: SPM 242

SLB1122168 formic

Cat.No: T78160

Target: LPL Receptor

Sphingosine-1-phosphate (d16:1)

Cat.No: T37955

Synonym: Sphingosine-1-phosphate (d16:1)

Cat.No: T70613

Cat.No: T10387

Target: Others

Cat.No: T70614

Cat.No: T70900

Cat.No: T41145

Cat.No: T71301

Siponimod hemifumarate

Cat.No: T64065

Cat.No: T37548

Synonym: azido-FTY720

Cat.No: T83893

W140 (trifluoroacetate salt)

Cat.No: T38336

Synonym: W140 (trifluoroacetate salt)

D-erythro/L-threo Lysosphingomyelin (d18:1)

Cat.No: T37187

Synonym: D-erythro/L-threo Lysosphingomyelin (d18:1)

Cat. No.	Product Name	Target	Signaling Pathways
T21500	Sphingosine-1-phosphate S1P	Endogenous Metabolite; S1P Receptor; LPL Receptor	GPCR/G Protein; Metabolism
	Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。
T7939	Fingolimod 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德	S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein
	Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。

天然产物

Sphingosine-1-phosphate

Cat.No: T21500

Synonym: S1P

Target: Endogenous Metabolite, S1P Receptor, LPL Receptor

Cat.No: T7939

Synonym: 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德

Target: S1P Receptor, PAK, LPL Receptor

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼