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15

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0204	Protriptyline hydrochloride 盐酸普罗替林,Protriptyline HCl	5-HT Receptor; AChE	GPCR/G Protein; Neuroscience
	Protriptyline hydrochloride (Protriptyline HCl) 是一种含有一个仲胺的三环结构抗抑郁试剂，可以用于抑郁和 ADHD 的相关研究。它使动物精力充沛起激励作用，并且有时用于嗜睡症的相关研究。
TP1159L	Boc-Gly-Gly-Phe-Gly-OH acetate Boc-Gly-Gly-Phe-Gly-OH acetate(187794-49-6 free base),GGFG acetate
	Boc-Gly-Gly-Phe-Gly-OH acetate (GGFG acetate)(187794-49-6 free base) 是 N 和 C 保护的四肽的自组装体。
T28860	ST-148 ST148
	ST-148 is a potent inhibitor for Dengue virus capsid. ST-148-enhanced capsid protein self-interaction perturbs assembly and disassembly of DV nucleocapsids, probably by inducing structural rigidity.
T29198	Z060228 Z 060228,Z-060228
	Z060228 is an potent anti-HBV inhibitor. The HBV DNA replication was effectively inhibited by Z060228 in the supernatants of the HepG2.2.15 cells. Z060228 exhibited effects on the self-assembly of Cp149. SEC data revealed that Z060228 altered the equilibr
TP1159	Boc-Gly-Gly-Phe-Gly-OH GGFG
	Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide.
TP1495	Boc-Gly-Gly-Phe-Gly-OH TFA(187794-49-6,free) Boc-Gly-Gly-Phe-Gly-OH TFA
	Boc-Gly-Gly-Phe-Gly-OH TFA is a self-assembly of N-protected and C-protected tetrapeptides and is a protease cleaved connector for antibody-drug binding (ADC).
T76652	PHF6
	PHF6 (VQIVYK) 为一自组装序列，能启动全长tau蛋白聚集，其定位于tau蛋白第三个微管结合重复区。
T60430	Protriptyline
	Protriptyline 是有效的抗抑郁剂，抑制AChE 活性(IC50 =.06 mM)，并可抑制 Aβ 自组装。Protriptyline 具有用于抑郁症和阿尔茨海默病的研究潜力。
T70941	CLR01 sodium
	CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.
T79224	Ara-SH	Apoptosis	Apoptosis
	Ara-SH为Cytarabine巯基丙酸取代的衍生物，应用于通过自组装技术制造携带Cytarabine和Venetoclax的智能共负载纳米颗粒(AV-NP)的触发器。在体外和体内实验中，Ara-SH展现出显著的协同抗白血病效果。
T73533	ADH-6
	ADH-6，一种三吡啶酰胺化合物，消除突变p53 DBD聚集成核亚结构域的自组装，并靶向解离人类癌细胞中的突变p53聚集体。通过此过程，ADH-6恢复p53的转录活性，导致细胞周期停滞与细胞凋亡(apoptosis)，展示了其研究癌症疾病的潜力。
T80362	Human α-Defensin 6
	Human α-Defensin 6，含32个半胱氨酸残基的抗菌肽，能够阻止细菌入侵，促进粘膜免疫。该肽通过自组装形成有序的原纤维和纳米网，能随机结合细菌表面蛋白，进而围绕并缠绕细菌。此外，Human α-Defensin 6抑制C. albicans生物膜的形成。
T74443	ADH-6 TFA
	ADH-6 TFA为三吡啶酰胺类化合物，通过靶向并解离人类癌细胞中突变p53聚集体，阻止突变p53 DBD聚集成核亚结构域的自组装，从而恢复p53的转录活性。这一过程导致细胞周期停滞和细胞凋亡(apoptosis)，显示出其在研究癌症疾病中的应用潜力。
T37105	2',3'-O-Isopropylideneguanosine
	2',3'-O-Isopropylideneguanosine is an alkylated guanosine building block.1,2It has been used in the synthesis of ordered honeycomb microporous films and mRNA cap analogs. 1.Gao, Y.-F., Huang, Y.-J., Xu, S.-Y., et al.Ordered honeycomb microporous films from self-assembly of alkylated guanosine derivativesLangmuir27(6)2958-2964(2011) 2.Kore, A.R., Shanmugasundaram, M., and Vlassov, A.V.Synthesis and application of a new 2',3'-isopropylidene guanosine substituted cap analogBioorg. Med. Chem. Lett.1...
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...

化合物

Protriptyline hydrochloride

Cat.No: T0204

Synonym: 盐酸普罗替林,Protriptyline HCl

Target: 5-HT Receptor, AChE

Boc-Gly-Gly-Phe-Gly-OH acetate

Cat.No: TP1159L

Synonym: Boc-Gly-Gly-Phe-Gly-OH acetate(187794-49-6 free base),GGFG acetate

Cat.No: T28860

Synonym: ST148

Cat.No: T29198

Synonym: Z 060228,Z-060228

Boc-Gly-Gly-Phe-Gly-OH

Cat.No: TP1159

Synonym: GGFG

Boc-Gly-Gly-Phe-Gly-OH TFA(187794-49-6,free)

Cat.No: TP1495

Synonym: Boc-Gly-Gly-Phe-Gly-OH TFA

Cat.No: T76652

Cat.No: T60430

Cat.No: T70941

Cat.No: T79224

Target: Apoptosis

Cat.No: T73533

Human α-Defensin 6

Cat.No: T80362

Cat.No: T74443

2',3'-O-Isopropylideneguanosine

Cat.No: T37105

Pal-KTTKS (acetate)

Cat.No: T36929

Cat. No.	Product Name	Target	Signaling Pathways
T2773	Vindoline 文朵灵,文多灵	Microtubule Associated	Cytoskeletal Signaling
	Vindoline 是从长春花叶片中提取的一种生物碱，通过抑制微管组装而表现出抗有丝分裂活性。

天然产物

Cat.No: T2773

Synonym: 文朵灵,文多灵

Target: Microtubule Associated

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