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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T22676	Prothrombin (474-477) [Mus musculus]	Others	Others
	Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T1184	Rivaroxaban BAY 59-7939,利伐沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂，IC50=0.7 nM，Ki 为 0.4 nM。
T1736	Apixaban 阿哌沙班,BMS-562247-01	Factor Xa	Metabolism
	Apixaban (BMS-562247-01) 是一种高度选择性，可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂，抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。
T20616	Coumachlor G-23133,Ratilan,G23133,Tomorin,G 23133
	Coumachlor, a first-generation anticoagulant rodenticide, blocks the formation of prothrombin and inhibits blood coagulation causing internal haemorrhage.
T75589	Bitis Cornuta Venom
	Bitis Cornuta Venom (Many-horned Adder Venom) 是从 Bitis Cornuta 提取的蛇毒，含有sPLA2毒素，该毒素具有通过抑制凝血酶原复合物以发挥抗凝活性的能力，并能促使凝血酶原转化为凝血酶，引发凝块形成。
TP1853	TP508
	TP508 is a 23 amino acid synthetic peptide representing residues 508-530 of human prothrombin which is identified as a potential receptor-binding domain based on competition for high-affinity thrombin binding to fibroblasts.TP508 (Chrysalin) is an investi
TP2234	coagulation factor II (thrombin) B chain fragment [Homo sapiens]	Others	Others
	Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble
T27698	JTV-803 mesylate JTV803,JTV 803,JTV-803
	JTV-803 is a factor Xa inhibitor. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM and IC(50) value of 0.081 microM. JTV-803 was 100 times more selective in inhibiting human factor Xa as compared to its
T36203	Menaquinone 9 MK-9,Vitamin K2(45),Menaquinone 9
	Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.

化合物

Prothrombin (474-477) [Mus musculus]

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Rivaroxaban

Cat.No: T1184

Synonym: BAY 59-7939,利伐沙班

Target: Factor Xa, Thrombin

Apixaban

Cat.No: T1736

Synonym: 阿哌沙班,BMS-562247-01

Target: Factor Xa

Coumachlor

Cat.No: T20616

Synonym: G-23133,Ratilan,G23133,Tomorin,G 23133

coagulation factor II (thrombin) B chain fragment [Homo sapiens]

Synonym: JTV803,JTV 803,JTV-803

Target:

Menaquinone 9

Cat.No: T36203

Synonym: MK-9,Vitamin K2(45),Menaquinone 9

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T0809	Dicoumarol Dicumarol,双羟香豆素,双香豆素	Dehydrogenase; NADPH; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂，它们的IC50值分别为 0.37 和 19.42 μM。

天然产物

Dicoumarol

Cat.No: T0809

Synonym: Dicumarol,双羟香豆素,双香豆素

Target: Dehydrogenase, NADPH, PDK

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