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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8425 |
Linoleoyl Ethanolamide
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Linoleoyl ethanolamide 是脂肪酸乙醇酰胺。它可弱结合 CB1 和 CB2 受体,并分别抑制[3H]CP-55,940的结合,Ki 分别为 10 和 25μM。它在引起小鼠过氧化氢酶方面的效力是 anandamide 的4倍,且对睡眠时间无延长效果。 | |||
T3574 |
Sematilide hydrochloride
司美利特,CK-1752A,CK-1752,Sematilide HCl |
Potassium Channel | Membrane transporter/Ion channel |
Sematilide hydrochloride (CK-1752) 是一种选择性的 IKr 通道阻滞剂。Sematilide 以浓度依赖性抑制延迟整流钾通道 (K+current),IC50为 25 μM。Sematilide 是一种 III 类抗心律不齐剂。 | |||
T6541 |
Ibutilide Fumarate
Corvert Fumarate,U70226E,富马酸伊布利特 |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物,可作用于急性心梗阻塞。 | |||
T0869 |
Atomoxetine hydrochloride
Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,盐酸托莫西汀,LY 139603,Atomoxetine HCl,LY 139603 HCl |
Dopamine Receptor; 5-HT Receptor; Norepinephrine | GPCR/G Protein; Neuroscience |
Atomoxetine hydrochloride (LY 139603) 是苯氧基-3-丙胺衍生物和选择性非兴奋剂,是去甲肾上腺素再摄取抑制剂,具有认知增强活性。 与人 NET,SERT 和 DAT 的放射性配体结合的 Ki 分别为5,77和1451 nM。 | |||
T15755 |
Lidoflazine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia. | |||
T21391 |
Flecainide
Tambocor,Apocard,Flecainida,Flecainidum |
||
Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3765 |
L-asarinin
細辛素,(-)-Episesamin |
Others | Others |
L-asarinin ((-)-Episesamin) 降低外周血 IL-12 浓度并抑制 CXCR3 和 TLR4 的表达,这意味着 Asarinin 可能在 TLR4 通路中发挥作用,并延长同种异体心脏的存活时间。 |