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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9153	Picotamide	Others	Others
	Picotamide 具有抗凝和纤维蛋白溶解特性。
T31091	CRANAD-28 CRANAD28	Others	Others
	CRANAD-28 是一种血脑屏障（BBB）穿透型双光子成像探头，能够显示淀粉样蛋白斑块，可以标记斑块和脑淀粉样血管病。
T23131	PE 154	AChE	Neuroscience
	PE 154是一种强效的 acetylcholinesterase (AChE) 和 butyrylcholinesterase (BChE) 荧光抑制剂，IC50 分别为 280 pM 和 16 nM。PE 154 在组织化学分析中常用来标记 β 淀粉样蛋白斑块。
T30506	BMS-212122 UNII-0Z473OO6GB,BMS212122,BMS 212122	CETP	Metabolism
	BMS-212122 (UNII-0Z473OO6GB) 是一种有效的微粒体甘油三酯转移蛋白(MTP )抑制剂，在动物实验中显示出降血脂作用。BMS-212122 显著减少动脉粥样硬化斑块中的脂质含量和单核细胞衍生(CD68+)细胞。
T17157	TRAF-STOP inhibitor 6877002 CD40-TRAF6 inhibitor	NF-κB	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂，可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化，减少白细胞募集和巨噬细胞的活化，减少动脉粥样硬化斑块中的巨噬细胞增殖。
T33448	ML 10 ML-10,ML10
	ML 10 is is a [18F] positron emission tomography (PET) radiotracer that accumulates in cells presenting apoptosis-specific membrane alterations. [18F]ML-10 allows for the detection of apoptotic cells located in atherosclerotic plaques.
T31801	Florbetapir F-18
	Florbetapir F-18 is a PET agent for Abeta plaques.
T10529	BF-168	Others	Others
	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
TP1729	β-Amyloid (10-35), amide
	β-Amyloid (10-35), amide, is a chemical compound consisting of 26 amino acids, specifically residues 10-35 of the Aβ peptide. It serves as the primary constituent of amyloid plaques found in Alzheimer's disease.
T64361	6-NBDG	Others	Others
	6-NBDG 是一种荧光葡萄糖类似物，可用作荧光探针。6-NBDG 可用于监测葡萄糖转运和摄取。6-NBDG 可用于检测富含巨噬细胞的动脉粥样硬化斑块。
T36727	9(S)-HODE
	9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.[1],[2] It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles.[3]
T74786	BIBD-124
	BIBD-124 通过与淀粉样蛋白 (Aβ) 斑块结合，展现出优异的亲和力，其 IC50 值达到了 9.51 nM。作为一种放射性示踪剂，[18F]BIBD-124 能够针对 Aβ 斑块进行高效的标记。
T38149	β-Amyloid (1-43)(human)
	The amyloid β-protein is a 39- to 43-amino acid polypeptide that is the primary constituent of senile plaques and cerebrovascular deposits in Alzheimer's disease and Down's syndrome. Additionally it acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro.
T39302	β-Amyloid (1-38), mouse, rat
	β-Amyloid (1-38), derived from mice and rats, is a chemical compound comprising 38 amino acids, specifically residues 1-38 of the Aβ peptide. Notably, it serves as the primary constituent of amyloid plaques associated with Alzheimer's disease.
T19904	Wollastonite Wollastonite (Ca(SiO3))
	Wollastonite is an industrial mineral comprised chemically of calcium, silicon, and oxygen. It has been determined to have low biopersistence in both in vivo and in vitro studies, which probably accounts for its relative lack of toxicity. There are no ple
T36948	NIAD-4
	NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (Ki = 10 nM). It displays excitation/emission spectra of 475/625 nm, respectively, with the far-red emission occurring upon binding to Aβ.
T75751	β-Amyloid (1-40) (TFA)
	β-Amyloid (1-40) TFA 是阿尔茨海默症患者脑斑块中发现的一种主要蛋白片段。
T74143	AZD4694 Precursor
	AZD4694 Precursor (AZ13040214) 为[18F] AZD4694合成前体，专用于[18F] AZD4694的合成。该前体作为淀粉样蛋白-β成像配体，展现对淀粉样蛋白-β斑块的高亲和性。
T75378	DCDAPH
	DCDAPH（Compound 2c）是用于β-淀粉样蛋白（Aβ）斑块检测的新型智能近红外探针，在PBS中λex/λem为597/665 nm。此化合物对Aβ具有高亲和性（Ki=37 nM，Kd=27 nM），并显示良好的血脑屏障渗透性，能够满足大多数体外及体内Aβ检测需求。
TP1228	β-Amyloid (1-16) Amyloid β-Protein (1-16),β-Amyloid 1-16
	β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is responsible for the formation of amyloid plaques in the brains of individuals affected by Alzheimer's disease (AD).
TP1673	β-Amyloid (11-22) β-Amyloid 11-22
	β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerat
T37367	Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi...
T70800	Elenbecestat free base
	Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.
T78426	MCAAD-3
	MCAAD-3为一种近红外Aβ成像探针，能穿透血脑屏障。其对Aβ聚合体拥有高亲和力（Ki >106 nM），能够在转基因小鼠大脑中标记Aβ斑块。
T81299	Remternetug LY3372993
	Remternetug为一种人源化IgG1-kappa型单克隆抗体，针对APP (Aβ42 N3pGlu)的特定焦谷氨酸形式。该抗体能够特异性识别并结合形成淀粉样斑块的Aβ聚集体。
T37472	TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
	TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease. Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers. TAMRA-Amyloid-β (1-42) peptide is a labeled form of Aβ42 containing carboxytetramethyl rhodamine (TAMRA), which displays excitation/emission maxima of 543/572 nm, respectively.
T74778	ASM-IN-1	Phospholipase	Metabolism
	ASM-IN-1是一种高效的口服活性ASM抑制剂，具有1.5 µM的IC50值。该化合物在减少主动脉弓及主动脉的脂质斑块方面表现出效果，并能够降低血浆中的神经酰胺以及Ox-LDL水平。ASM-IN-1展现了抗动脉粥样硬化与抗炎的活性。
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。
T36731	Cholesteryl Heptadecanoate
	Cholesteryl heptadecanoate is a cholesterol ester (CE) formed by the condensation of cholesterol with heptadecanoic acid, a C-17 saturated fatty acid that does not occur in any natural animal or vegetable fat at high concentrations. As such, it is commonly used as an internal standard for the quantification of cholesterol esters by GC- or LC-mass spectrometry. CEs are major constituents of lipoprotein particles carried in blood and accumulate in the fatty acid lesions of atherosclerotic plaques....
T76394	Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)
	Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42) 为β淀粉样蛋白36至42氨基酸片段，构成阿尔茨海默病患者大脑淀粉样斑块的核心组分。此多肽链含36-43个氨基酸，而β淀粉样低聚物(Aβos)通过引起神经损伤与认知功能障碍，在阿尔茨海默病发展中扮演重要角色。
T37393	13(S)-HpODE
	13(S)-HpODE is produced by the oxidation of linoleic acid by lipoxygenase-1 (LO-1) in many plants including soybean, flaxseed, apples, and tea leaves,1,2 and by 15-LO in mammals.3 In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase.4 In mammalian tissues, 13(S)-HpODE is generally reduced to 13(S)-HODE，a compound which exhibits many biological activities.3 A direct action for 13(S)-HpODE has been demonstrated in Syrian hamster embryo cells where it stimula...
TP2177	Amyloid Precursor C-Terminal Peptide	Others	Others
	Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose am
T82684	Connexin mimetic peptide 40,37GAP26
	Connexin mimetic peptide 40,37GAP26是一种生物活性肽，对应Cx37和Cx40主要血管连接蛋白的胞外环GAP26结构域，命名基于Cx同源性为37,40Gap26。本化合物主要用于研究间隙连接对环吡嗪酸(CPA)通过啮齿动物髂动脉壁导致的内皮超极化扩散的影响。Cx37和Cx40形成的间隙连接斑块在内皮细胞中高度丰富，而Connexin mimetic peptide 40,37GAP26能抑制内膜下超极化。
T35498	β-Amyloid (1-14),mouse,rat
	β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru...

化合物

Cat.No: T9153

Target: Others

Cat.No: T31091

Synonym: CRANAD28

Target: Others

Cat.No: T23131

Target: AChE

Cat.No: T30506

Synonym: UNII-0Z473OO6GB,BMS212122,BMS 212122

Target: CETP

TRAF-STOP inhibitor 6877002

Cat.No: T17157

Synonym: CD40-TRAF6 inhibitor

Target: NF-κB

Cat.No: T33448

Synonym: ML-10,ML10

Florbetapir F-18

Cat.No: T31801

Cat.No: T10529

Target: Others

β-Amyloid (10-35), amide

Cat.No: TP1729

Cat.No: T64361

Target: Others

Cat.No: T36727

Cat.No: T74786

β-Amyloid (1-43)(human)

Cat.No: T38149

β-Amyloid (1-38), mouse, rat

Cat.No: T39302

Cat.No: T19904

Synonym: Wollastonite (Ca(SiO3))

Cat.No: T36948

β-Amyloid (1-40) (TFA)

Cat.No: T75751

AZD4694 Precursor

Cat.No: T74143

Cat.No: T75378

β-Amyloid (1-16)

Cat.No: TP1228

Synonym: Amyloid β-Protein (1-16),β-Amyloid 1-16

β-Amyloid (11-22)

Cat.No: TP1673

Synonym: β-Amyloid 11-22

Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37367

Elenbecestat free base

Cat.No: T70800

Cat.No: T78426

Cat.No: T81299

Synonym: LY3372993

TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

Cat.No: T37472

Cat.No: T74778

Target: Phospholipase

Cat.No: T76393

Cholesteryl Heptadecanoate

Cat.No: T36731

Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)

Cat.No: T76394

Cat.No: T37393

Amyloid Precursor C-Terminal Peptide

Cat.No: TP2177

Target: Others

Connexin mimetic peptide 40,37GAP26

Cat.No: T82684

β-Amyloid (1-14),mouse,rat

Cat.No: T35498

Cat. No.	Product Name	Target	Signaling Pathways
T1068	Dithranol 1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Dithranol (cignoline) 是蒽醌衍生物，可破坏线粒体功能和结构，用于治疗皮肤病。

天然产物

Cat.No: T1068

Synonym: 1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin

Target: Others, DNA/RNA Synthesis

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