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Search Results for " pancreatic α "

17

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1137L	Pancreatic Polypeptide (human) acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽，可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。
TP1044L	Pancreatic Polypeptide, rat acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide, rat acetate 是 NPY 受体的激动剂，对 NPYR4 具有高亲和力。
T15389L	Glucagon (1-29), bovine, human, porcine hydrochloride 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride	Glucocorticoid Receptor; Glucagon Receptor	Endocrinology/Hormones; GPCR/G Protein
	Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化，促进糖异生。
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T76538	Pancreatic polypeptide
	Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽，具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。
T63015	Pancreatic lipase/Carboxylesterase 1-IN-1
	Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂，作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。
T6157	Devimistat CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis; Dehydrogenase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) 是一种线粒体代谢抑制剂，还是一种lipoic acid 拮抗剂，能阻断线粒体能量代谢，诱导多种癌细胞凋亡。
T67924	ABzOH
	ABzOH 是一种苯甲酸衍生物，结构类似于阿司匹林等非甾体抗炎药，具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。
T37834	G3-CNP
	G3-CNP is a colorimetric substrate for α-amylases.1Upon hydrolysis by α-amylases, 2-chloro-4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity. G3-CNP has been used to characterize the activity of human pancreatic or salivary amylase.
T74255	HPA-IN-1
	HPA-IN-1 (Compound 1)为高效、选择性的人类胰腺α淀粉酶(HPA)抑制剂，其对HPA及α-glucosidase的IC50值分别为12.0 μM与410.4 μM。
T29154	WB403 WB-403,WB 403
	WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α-
T15389	Glucagon (1-29), bovine, human, porcine 胰高血糖素,Porcine glucagon,Glucagon	Others	Others
	Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T72970	Rosolic Acid 蔷薇色酸
	Rosolic Acid是Nrf2及其下游靶点的激活剂，能够提升血管生成因子的水平，并降低TNF-α和IL-1β等炎症标志物以及CXCL10和CCL2等凋亡标志物的水平。同时，Rosolic Acid能够恢复胰腺细胞功能，并对受到内质网应激影响的内皮细胞(EC)提供保护。
T36380	GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
	GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans...
T70882	Orlistat-d3
	Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit...
T76255	Certepetide
	Certepetide (CEND-1)，即双功能环肽（a.k.a. iRGD），是一种具有穿透肿瘤功能的多肽。通过与α-V整联蛋白（alphav-integrins）的RGD motif相互作用，以及激活神经纤毛蛋白1（NRP-1），Certepetide能够将实体瘤微环境转化成临时的活性分子通道，从而在肿瘤中累积。该化合物在胰腺癌和其他实体瘤的研究中具有应用潜力。

化合物

Pancreatic Polypeptide (human) acetate

Cat.No: TP1137L

Target: Neuropeptide Y Receptor

Pancreatic Polypeptide, rat acetate

Cat.No: TP1044L

Target: Neuropeptide Y Receptor

Glucagon (1-29), bovine, human, porcine hydrochloride

Cat.No: T15389L

Synonym: 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride

Target: Glucocorticoid Receptor, Glucagon Receptor

Cat.No: T6823

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Pancreatic polypeptide

Cat.No: T76538

Pancreatic lipase/Carboxylesterase 1-IN-1

Cat.No: T63015

Cat.No: T6157

Synonym: CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism

Cat.No: T67924

Cat.No: T37834

Cat.No: T74255

Cat.No: T29154

Synonym: WB-403,WB 403

Glucagon (1-29), bovine, human, porcine

Cat.No: T15389

Synonym: 胰高血糖素,Porcine glucagon,Glucagon

Target: Others

Cat.No: T36408

Synonym: Rhein-13C4

Cat.No: T72970

Synonym: 蔷薇色酸

GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)

Cat.No: T36380

Cat.No: T70882

Cat.No: T76255

Cat. No.	Product Name	Target	Signaling Pathways
T3S0013	Ethyl trans-caffeate 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester	Others	Others
	Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。它是一种有前途的天然化合物，未来在慢性肝病中的应用。它是一种有效的化学预防化合物，可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。它强烈抑制 JB6 Cl41细胞的肿瘤转化，无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
T80702	α-Thevetin B
	α-Thevetin B（Compound 24）, 一种从Thevetia peruviana分离得到的心脏苷，用于肺癌、胃癌和胰腺癌的研究。
T83308	5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl
	5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) 是从漏斗石斛 (D. infundibulum) 中分离出的化合物。该化合物不具有对 α-葡萄糖苷酶和胰脂肪酶的抑制活性。

天然产物

Ethyl trans-caffeate

Cat.No: T3S0013

Synonym: 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester

Target: Others

Cat.No: T80702

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl

Cat.No: T83308

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