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Search Results for " palmitoyltransferase "

19

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78569	CPT2 Carnitine palmitoyltransferase 2	Apoptosis	Apoptosis
	CPT2 (Carnitine palmitoyltransferase 2) 是一种脂肪酸氧化过程中的酶，它在结直肠癌 (CRC) 预后评估中作为生物标志物。CPT2 通过过表达激活p-p53并增加p53蛋白水平，这有助于抑制肿瘤生长和促进细胞的凋亡。CPT2 缺乏是长链脂肪酸氧化障碍相关的常见遗传性疾病，并且CPT2 的表达降低与多种癌症的发展密切相关，因此，在癌症研究领域具有研究价值。
T4535	Etomoxir sodium salt (R)-(+)-乙莫克舍钠盐,(R)-Etomoxir sodium salt,Na salt,Etomoxir	Apoptosis; Others	Apoptosis; Others
	Etomoxir sodium salt ((R)-Etomoxir sodium salt) 是一种肉碱棕榈酰转移酶 1a (CPT-1a) 抑制剂，可以阻断脂肪酸合成。Etomoxir sodium salt 具有抗肿瘤活性。
T11978	McN3716 NSC359682,Methyl palmoxirate	Mitochondrial Metabolism; CPT	Metabolism
	McN3716 是一种肉碱棕榈酰转移酶 I (CPT-1) 抑制剂，可用于研究代谢疾病。
T26308	Lipoxamycin hemisulfate Lipoxamycin, sulfate (2:1),U-26146D,U26146D,U 26146D,Lipoxamycin	Antifungal	Microbiology/Virology
	Lipoxamycin hemisulfate (Lipoxamycin) 是一种丝氨酸棕榈酰转移酶抑制剂 (IC50 = 21 nM)，具有抗真菌活性。
T4535L	Etomoxir (R)-(+)-Etomoxir	Antioxidant; CPT	Metabolism; oxidation-reduction
	Etomoxir 是肉碱棕榈酰转移酶 1a （CPT-1a）抑制剂，通过抑制 CPT-1a 来抑制脂肪酸氧化，且抑制人、大鼠和豚鼠中棕榈酸酯的氧化。Etomoxir 对腺嘌呤核苷酸转位酶有抑制作用，可通过破坏CoA稳态来抑制巨噬细胞极化。
T35364	2-Bromohexadecanoic acid 2-BP,2-溴十六烷酸,2-bromopalmitate,2-Bromohexadecanoic acid	Others	Others
	2-Bromohexadecanoic acid (2-BP) 是一种不可代谢的棕榈酸酯类似物，可用作棕榈酰化抑制剂。它直接且不可逆地抑制所有 DHHC (Asp-His-His-Cys) 蛋白的棕榈酰转移酶活性。
T26308L	Lipoxamycin HCl Lipoxamycin HCl（11075-87-9 Free base）
	Lipoxamycin HCl 是一种高效的丝氨酸棕榈酰转移酶 (serine palmitoyltransferase) 抑制剂，具有抗真菌活性，抑制丝氨酸棕榈酰转移酶活性。
T68618	S-(-)-Etomoxir
	S-(-)-Etomoxir is an inhibitor of carnitine palmitoyltransferase A (CPT1) -- a molecule required for the oxidation of long-chain acyl CoA esters.
T38685	C12-Sphingosine C12-Sphingosine
	C12-Sphingosine is a short-chain homologue of Sphingosine. It effectively inhibits the activity of serine palmitoyltransferase in primary cultured cerebellar cells.
T68196	Aminocarnitine
	Aminocarnitine is an inhibitor of fatty acid oxidation that acts as a hypoglycemic and antiketogenic compound. It alters lipidic metabolism by inhibiting carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (CPT).
T68445	Clomoxir
	Clomoxir is a carnitine palmitoyltransferase I inhibitor that was under development as an antiarrhythmic and antidiabetic.
T37245	Palmitoyl-D-carnitine (chloride)
	Palmitoyl-D-carnitine is a long-chain acylcarnitine, an isomer of palmitoyl-L-carnitine , and the D enantiomer of palmitoyl-DL-carnitine . It inhibits carnitine palmitoyltransferase with a Ki value of 2.1 mM for 14C-palmitoylcarnitine synthesis by erythrocyte membranes.
T71554	ARN 14494
	ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
T83767	4-Hydroxyphenylglyoxylic Acid UK 22486
	4-Hydroxyphenylglyoxylic acid 是一种抑制剂，针对 carnitine palmitoyltransferase 1 (CPT1)，同时也是前药 oxfenicine 的活性代谢物。在 200 至 1,000 µM 的浓度范围内，该化合物能够抑制离体大鼠肝线粒体中的 CPT1，并能够抑制离体大鼠肝细胞中的油酸氧化。
T73829	Malonyl CoA
	Malonyl CoA是脂肪酸生物合成的重要底物，同时也担任脂肪酸氧化过程中的抑制剂角色。此外，Malonyl CoA亦作为线粒体肉碱棕榈酰转移酶1（CPT1）的可逆性抑制剂。
T38214	1-Deoxysphingosine (m18:1(4E)) 1-Deoxysphingosine (m18:1(4E))
	1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).3 \|1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemica...
T38284	C24 dihydro 1-Deoxyceramide (m18:0/24:0) C24 dihydro 1-Deoxyceramide (m18:0/24:0)
	C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, ...
T38280	C22 dihydro 1-Deoxyceramide (m18:0/22:0) C22 dihydro 1-Deoxyceramide (m18:0/22:0)
	C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C22 dihydro 1-Deoxyceramide (m18:0/22:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found as the most prevalent dihydro...
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...

化合物

Cat.No: T78569

Synonym: Carnitine palmitoyltransferase 2

Target: Apoptosis

Etomoxir sodium salt

Cat.No: T4535

Synonym: (R)-(+)-乙莫克舍钠盐,(R)-Etomoxir sodium salt,Na salt,Etomoxir

Target: Apoptosis, Others

Cat.No: T11978

Synonym: NSC359682,Methyl palmoxirate

Target: Mitochondrial Metabolism, CPT

Lipoxamycin hemisulfate

Cat.No: T26308

Synonym: Lipoxamycin, sulfate (2:1),U-26146D,U26146D,U 26146D,Lipoxamycin

Target: Antifungal

Cat.No: T4535L

Synonym: (R)-(+)-Etomoxir

Target: Antioxidant, CPT

2-Bromohexadecanoic acid

Cat.No: T35364

Synonym: 2-BP,2-溴十六烷酸,2-bromopalmitate,2-Bromohexadecanoic acid

Target: Others

Lipoxamycin HCl

Cat.No: T26308L

Synonym: Lipoxamycin HCl（11075-87-9 Free base）

Cat.No: T68618

C12-Sphingosine

Cat.No: T38685

Synonym: C12-Sphingosine

Cat.No: T68196

Cat.No: T68445

Palmitoyl-D-carnitine (chloride)

Cat.No: T37245

Cat.No: T71554

4-Hydroxyphenylglyoxylic Acid

Cat.No: T83767

Synonym: UK 22486

Cat.No: T73829

1-Deoxysphingosine (m18:1(4E))

Cat.No: T38214

Synonym: 1-Deoxysphingosine (m18:1(4E))

C24 dihydro 1-Deoxyceramide (m18:0/24:0)

Cat.No: T38284

Synonym: C24 dihydro 1-Deoxyceramide (m18:0/24:0)

C22 dihydro 1-Deoxyceramide (m18:0/22:0)

Cat.No: T38280

Synonym: C22 dihydro 1-Deoxyceramide (m18:0/22:0)

Nicotinamide-d4

Cat.No: T69395

Cat. No.	Product Name	Target	Signaling Pathways
T4785	Oxfenicine 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine	Others	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。
T36831	9-Oxononanoic Acid 9-ONA	Phospholipase; CPT	Metabolism
	9-Oxononanoic Acid是一种氧化脂肪酸，由亚油酸自氧化形成，它能提高磷脂酶 A2（PLA2）的活性，并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成，并提高大鼠肝脏肉碱棕榈酰转移酶（β-氧化的标志物）的活性。
T16165	Myriocin ISP-I,Thermozymocidin	HCV Protease; Antifungal	Microbiology/Virology; Proteases/Proteasome
	Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物，是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性，通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染，可用于研究神经病变和真菌感染。

天然产物

Cat.No: T4785

Synonym: 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine

Target: Others

9-Oxononanoic Acid

Cat.No: T36831

Synonym: 9-ONA

Target: Phospholipase, CPT

Cat.No: T16165

Synonym: ISP-I,Thermozymocidin

Target: HCV Protease, Antifungal

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