35
1
18
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14521 |
BDP9066
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
BDP9066 是一种具有强效性和选择性的 MRCK 抑制剂,抑制 MRCKβ 和 MRCKα/β ,可用于预防和治疗皮肤癌。 | |||
TP1549L |
NY-BR-1 p904 A2 acetate(347142-73-8 free base)
|
Others | Others |
NY-BR-1 p904 A2 acetate(347142-73-8 free base) 对这种 NY-BR-1 表位 (p904) 特异的 T 细胞克隆可以识别表达 NY-BR-1 的乳腺肿瘤细胞。 | |||
T63828 | Hsp90-IN-16 | ||
Hsp90-IN-16 是 HSP90 抑制剂,能够有效的、高度选择性的作用于 HER2 阳性癌细胞。Hsp90-IN-16 能够抑制 HCC1954 乳腺癌细胞的增殖,其 IC50 值为 6 μM。Hsp90-IN-16 能够抑制HSP90“客户”蛋白,包括一个关键的致癌受体HER2/neu,诱导癌细胞凋亡。 | |||
T61904 | HSP90-IN-14 | ||
HSP90-IN-14 (compound 4) 是有效的Hsp90 抑制剂(Kd= 0.26μM)。在MDCK 细胞中,HSP90-IN-14 表现出抗流感病毒活性,抗 A/H3N2、A/H1N1 和 B 型流感病毒的EC50分别为 2.6、3.9 和 17 μM。 | |||
T78942 |
HSP90-IN-23
|
HSP | Cytoskeletal Signaling; Metabolism |
HSP90-IN-23 (Comp 12-1)为热休克蛋白90 (HSP90)的抑制剂,具有9 nM的IC50值。该化合物能够诱导肿瘤细胞凋亡,并抑制肿瘤细胞在G0/G1期的细胞周期。HSP90-IN-23常用于肿瘤学领域的研究。 | |||
T61938 |
HSP90-IN-12
|
||
vibsanin A 类似物 C(VAC)是一种抗癌化合物,对各种癌细胞系显示出抗增殖作用,且抗增殖活性在 vibsanin A 类似物中较强。VAC 使细胞中 HSP90相关蛋白的量波动,并显示出对 HSP90介导的荧光素酶体外蛋白重折叠的抑制作用。 | |||
T73037 |
HSP90-IN-18
|
||
HSP90-IN-18, 作为一种高效的热休克蛋白90(Hsp90)抑制剂,显示出了显著的抑制活性,其IC50值仅为0.39 μM。该化合物广泛应用于病毒感染、神经退行性疾病以及炎症等研究领域。 | |||
T13725 |
Hsp90-Cdc37-IN-1
|
Others | Others |
Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance. | |||
T63531 |
HDAC6/HSP90-IN-1
|
||
HDAC6/HSP90-IN-1 是有效的、选择性的 HDAC6 (IC50: 4.3 nM) 和 HSP90 (IC50: 46.8 nM) 的双重抑制剂。HDAC6/HSP90-IN-1 能够下调 INF-γ 处理的 H1975 肺癌细胞中 PD-L1 的表达。HDAC6/HSP90-IN-1 在 H1975 异种移植小鼠中表现出肿瘤生长的抑制作用。 | |||
T62163 |
Hsp90-IN-15
|
||
Hsp90-IN-15 是一种 Hsp90 抑制剂,具有抗癌作用。Hsp90-IN-15 能够将细胞周期阻滞在 S 期,诱导细胞凋亡 (apoptosis),并可以减少 Hela 细胞中 Hsp90 的表达水平。 | |||
T63528 | HSP90-IN-11 | ||
HSP90-IN-11 是 HSP90 的有效抑制剂,诱导亚 G1 期群体的显着积累。 HSP90-IN-11 具有与 AUY-922 (Luminespib) 相当的有效 HSP90α 抑制作用。在 CRC 和 NSCLC 细胞中,HSP90-IN-11 具有显着的抗增殖活性,在两位数 nM 范围内。HSP90-IN-11 能够快速降解 NSCLC 细胞中客户蛋白 EGFR 和 Akt 。 | |||
T73011 | HSP90-IN-20 | ||
HSP90-IN-20 是一种有效的 HSP90抑制剂,IC50为 ≤10 μM。HSP90-IN-20 具有用于癌症研究的潜力。 | |||
T72225 |
Hsp90-IN-17 hydrochloride
|
||
Hsp90-IN-17 (Example 5) hydrochloride,一种针对增殖性疾病如癌症和神经退行性疾病研究的HSP90抑制剂。 | |||
T63529 |
HDAC/HSP90-IN-3
|
||
HDAC/HSP90-IN-3 是选择性的、有效的真菌 Hsp90 (IC50: 0.83 μM) 和 HDAC (IC50: 0.91 μM) 双重抑制剂,对耐唑白色念珠菌表现出抗真菌作用。HDAC/HSP90-IN-3 对重要毒力因子表现出抑制作用,能够下调耐药基因ERG11和CDR1。 | |||
T64263 | HSP90-IN-9 | ||
HSP90-IN-9 是一种选择性的、有效的 HSP90 抑制剂。HSP90-IN-9 以剂量依赖性地表现出杀真菌效果。HSP90-IN-9 联合 FLC 用药,可以抑制真菌生物膜形成和真菌形态变化。HSP90-IN-9 能够下调 ERG11、CDR1 和 CDR2 基因表达,恢复 FLC 的耐药性。 | |||
T82166 | HSP90-IN-27 | HSP | Cytoskeletal Signaling; Metabolism |
HSP90-IN-27(化合物19)是一种HSP90抑制剂。 | |||
T79487 | MAO A/HSP90-IN-2 | Monoamine Oxidase | Neuroscience |
MAO A/HSP90-IN-2(compound 4-C)是一种针对HSP90和MAO A的双重抑制剂,显示出分别对这两种酶有0.016 μM和4.58 μM的IC50值。该化合物能够上调HSP70,降低HER2和磷酸化AKT的表达,同时能减少GL26细胞中由IFN-γ诱导的PD-L1表达增加。此外,MAO A/HSP90-IN-2能够抑制对Temozolomide敏感或耐药的胶质母细胞瘤(GBM)、结肠癌、白血病和非小细胞肺癌细胞的生长,并可能有助于阻止肿瘤逃避免疫监控。 | |||
T78863 |
HSP90-IN-25
|
HSP | Cytoskeletal Signaling; Metabolism |
HSP90-IN-25 (化合物4a) 作为一种HSP90抑制剂,其作用机制为特异性抑制HSP90的ATPase活性。 | |||
T63205 |
HSP90-IN-13
|
||
HSP90-IN-13(compound 5k)是一种有效的HSP90抑制剂,具有25.07 nM的IC50值,并对EGFR、VEGFR-2以及Topoisomerase-2展现出多靶点作用。此外,HSP90-IN-13能够在G2/M期阻滞MCF-7细胞周期,并通过线粒体途径诱导细胞凋亡(apoptosis)。 | |||
T79083 | HSP90-IN-22 | HSP | Cytoskeletal Signaling; Metabolism |
HSP90-IN-22(Compound 35)作为Hsp90抑制剂,对MCF7乳腺癌细胞的IC50为3.65μM,对SKBr3乳腺癌细胞的IC50为2.71μM,显示出对这些细胞系具有显著的抗增殖活性。 | |||
T61315 | HDAC6/HSP90-IN-2 | ||
HDAC6/HSP90-IN-2 (compound 6e) 是HDAC6和Hsp90的双抑制剂其IC50s 分别为106 nM 和61 nM。HDAC6/HSP90-IN-2 (compound 6e) 可用于癌症的研究。 | |||
T73835 | PROTAC HSP90 degrader BP3 | ||
PROTACHSP90 degrader BP3 以 CRBN 依赖性方式有效且选择性地降解 HSP90。PROTACHSP90 degrader BP3对 MCF-7 细胞中的 HSP90蛋白有一定的降解作用 (DC50=0.99 µM)。PROTACHSP90 degrader BP3 抑制乳腺癌细胞的生长。 | |||
T79323 |
PROTAC Hsp90α degrader 1
|
HSP | Cytoskeletal Signaling; Metabolism |
PROTACHsp90α degrader 1 (Compound X10g) 是一款选择性的PROTACHsp90α降解剂,专用于乳腺癌细胞研究。它对MDA-MB-231、MDA-MB-468、MCF-7、及MX-1等乳腺癌细胞系表现出显著的增殖抑制作用,其IC50s值分别为51.48 μM、16.46 μM、8.93 μM、和11.95 μM。 | |||
T63827 | HSP90-IN-10 | ||
HSP90-IN-10 是 HSP90 的有效抑制剂。HSP90-IN-10 对 HCC1954 乳腺癌细胞表现出强大的抗增殖效果 (IC50: 6 μM)。HSP90-IN-10 能够诱导细胞凋亡 (apoptosis),且不抑制正常上皮细胞的生长。 | |||
T64261 | HDAC/HSP90-IN-4 | ||
HDAC/HSP90-IN-4 能够明显抑制 HDAC 和 HSP90 的活性,化合物20(HDACIC50= 194 nM; HSP90αIC50= 153 nM)和化合物26((HDACIC50= 360 nM; HSP90αIC50= 77 nM) 具有较强的 HDAC 和 HSP90α抑制效果。这两种化合物都能诱导 HSP90表达并下调 HSP90客户蛋白,而 HSP90客户蛋白在调节癌细胞的生存和侵袭中发挥着重要作用。 | |||
T62307 | Aha1/Hsp90-IN-1 | ||
Aha1/Hsp90-IN-1 (Compound 17) 是一种 Aha1/Hsp90 complex 抑制剂,对 tau 蛋白聚集具有抑制作用。Aha1/Hsp90-IN-1 能够破坏 Aha1/Hsp90 的相互作用 (IC50: 3.32 μM)。 | |||
T79486 | MAO A/HSP90-IN-1 | Monoamine Oxidase | Neuroscience |
MAO A/HSP90-IN-1 (4-b) 是一种针对MAO A和HSP90的双重抑制剂,展现在恶性胶质瘤GL26细胞上的IC50为1.77 μM,针对HSP90α的IC50为0.019 μM。该化合物能够通过抑制MAO A活性和HSP90结合,以及降低HER2和phospho-Akt表达,进而抗击恶性胶质瘤(GMB)。同时,MAO A/HSP90-IN-1 (4-b)可减少PD-L1的表达,从而降低T细胞活化的抑制,有望用来抑制肿瘤的免疫逃逸。该化合物适用于脑肿瘤相关疾病研究。 | |||
T73038 | HSP90-IN-19 | HSP | Cytoskeletal Signaling; Metabolism |
HSP90-IN-19 是一种高效 Hsp90 抑制剂,其 IC50 值仅为 0.27 μM。该化合物在病毒感染、神经退行性疾病及炎症相关研究中具有潜在应用价值。 | |||
T72780 |
HSP90/mTOR-IN-1
|
||
HSP90/mTOR-IN-1 是一种有效的Hsp90和mTOR 抑制剂,IC50分别为 69 nM 和 29 nM。HSP90/mTOR-IN-1 通过过度激活PI3K/AKT/mTOR 通路抑制 SW780 细胞增殖。HSP90/mTOR-IN-1 通过对HSP90和mTOR 的选择性抑制来诱导细胞凋亡 (apoptosis) 和细胞自噬 (autophagy)。HSP90/mTOR-IN-1 在异种移植小鼠体内也表现出良好的抗肿瘤活性。HSP90/mTOR-IN-1 可用于膀胱癌的研究。 | |||
T61182 |
(R)-BDP9066
|
||
(R)-BDP9066 is a highly effective inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK), effectively impeding cancer cell invasion, making it an invaluable resource for studying and researching proliferative diseases, particularly cancer. | |||
T72996 |
Hsp90-IN-17
|
||
Hsp90-IN-17 (Example 5),一种HSP90抑制剂,适用于增殖性疾病如癌症及神经退行性疾病研究。 | |||
TP1549 |
NY-BR-1 p904 (A2)
NY-BR-1 p904 A2 |
||
T-cell clones specific for this NY-BR-1 epitope (p904) can recognize breast tumor cells expressing NY-BR-1. | |||
T80622 |
Trontinemab
|
||
Trontinemab为一种双特异性人源IgG1-κ抗体,靶向Aβ前体蛋白(APP)与转铁蛋白受体p90, CD71 (TFRC)。该抗体主要应用于阿兹海默症研究。 | |||
T6878 |
LJI308
|
S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
LJI308 是泛RSK 抑制剂,对 RSK1、RSK2 和 RSK3 的IC50分别为 6、4 和 13 nM。它抑制辐照、EGF 处理和表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。 | |||
T11310 |
FMK-MEA
|
Others | Others |
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16896 |
SL 0101-1
SL0101 |
S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
SL 0101-1 (SL0101) 是一种可透过细胞膜且具有选择性、高效性、可逆性、ATP竞争性的 p90核糖体S6激酶(RSK) 的抑制剂,对 RSK 的 IC50 值为 89 nM。SL 0101-1 (SL0101) 也是一种有效的 RSK1/2 抑制剂,其 Ki 值为 1 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01873 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (His)
TFR1,p90,CD71,TFR,transferrin receptor,T9,TRFR,TR |
Human | HEK293 Cells |
Transferrin Receptor/TFRC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is AAA61153.1. | |||
TMPY-05096 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc)
CD71,T9,transferrin receptor,TFR1,p90,TRFR,TFR,TR |
Human | HEK293 Cells |
Transferrin Receptor/TFRC Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.6 kDa and the accession number is CAA25527.1. | |||
TMPY-02294 |
Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His)
2610028K12Rik,p90,E430033M20Rik,AI426448,TFR,AU0157... |
Mouse | HEK293 Cells |
Transferrin Receptor/TFRC Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.3 kDa and the accession number is Q62351. | |||
TMPY-03112 |
Calnexin Protein, Human, Recombinant (hFc)
P90,calnexin,CNX,IP90 |
Human | HEK293 Cells |
Calnexin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.4 kDa and the accession number is P27824. | |||
TMPK-00374 |
Transferrin R/CD71 Protein, Human, Recombinant (His & Avi)
p90,TFR,sTfR,T9,TFRC,TfR1,CD71,TR |
Human | HEK293 Cells |
The transferrin receptor (CD71) is known as a receptor for IgA1 on mesangial cells. The transcript and protein expression of glomerular CD71 was determined by real-time polymerase chain reaction and immunohistochemistry. Human mesangial cells (HMCs) were treated with sera from IgAN patients and expression levels of CD71 and inflammatory cytokine markers were compared according to disease status. Transferrin R/CD71 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells wit... | |||
TMPK-00375 |
Transferrin R/CD71 Protein, Human, Recombinant (His & Avi), Biotinylated
TFRC,sTfR,T9,p90,CD71,TR,TFR,TfR1 |
Human | HEK293 Cells |
The transferrin receptor (CD71) is known as a receptor for IgA1 on mesangial cells. The transcript and protein expression of glomerular CD71 was determined by real-time polymerase chain reaction and immunohistochemistry. Human mesangial cells (HMCs) were treated with sera from IgAN patients and expression levels of CD71 and inflammatory cytokine markers were compared according to disease status. Transferrin R/CD71 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mamma... | |||
TMPK-01261 |
Transferrin R/CD71 Protein, Cynomolgus, Recombinant (His)
TFR,T9,CD71,TfR1,sTfR,TFRC,TR,p90 |
Cynomolgus | HEK293 Cells |
The transferrin receptor (CD71) is known as a receptor for IgA1 on mesangial cells. The transcript and protein expression of glomerular CD71 was determined by real-time polymerase chain reaction and immunohistochemistry. Human mesangial cells (HMCs) were treated with sera from IgAN patients and expression levels of CD71 and inflammatory cytokine markers were compared according to disease status. Transferrin R/CD71 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with... | |||
TMPK-00376 |
Transferrin R/CD71 Protein, Human, Recombinant (hFc)
sTfR,CD71,TfR1,TFR,p90,TFRC,TR,T9 |
Human | HEK293 Cells |
The transferrin receptor (CD71) is known as a receptor for IgA1 on mesangial cells. The transcript and protein expression of glomerular CD71 was determined by real-time polymerase chain reaction and immunohistochemistry. Human mesangial cells (HMCs) were treated with sera from IgAN patients and expression levels of CD71 and inflammatory cytokine markers were compared according to disease status. Transferrin R/CD71 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hF... | |||
TMPJ-00378 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (aa 101-760, His)
p90,TfR,T9,Trfr,Transferrin receptor protein 1,TR |
Human | HEK293 Cells |
Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron o... | |||
TMPY-05617 |
Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated
TRFR,p90,TR,TFR,CD71,TFR1,T9,transferrin receptor |
Human | HEK293 Cells |
Transferrin Receptor/TFRC Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.4 kDa and the accession number is P02786. | |||
TMPJ-00923 |
Calnexin Protein, Human, Recombinant (His)
p90,Calnexin,CANX,Major Histocompatibility Complex ... |
Human | HEK293 Cells |
Calnexin/CANX is a single-pass type I membrane protein which belongs to the calreticulin family. It consists of a large N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail. The function of calnexin is to retain unfolded or unassembled N-linked glycoproteins in the endoplasmic reticulum. Calnexin is a calcium-binding protein that interacts briefly with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin may ... | |||
TMPY-04392 |
RSK3 Protein, Human, Recombinant (GST)
HU-2,ribosomal protein S6 kinase, 90kDa, polypeptide 2,S6K-α... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a... | |||
TMPY-01478 |
HSP90 alpha Protein, Human, Recombinant
Hsp89,Hsp90,HSPCAL1,heat shock protein 90kDa alpha ... |
Human | E. coli |
HSP90 alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.6 kDa and the accession number is K9JA46. | |||
TMPY-06846 |
HSP90 alpha Protein, Mouse, Recombinant (His)
AL024080,Hspca,hsp4,Hsp86-1,heat shock protein 90kDa α (cyto... |
Mouse | Baculovirus Insect Cells |
HSP90 alpha Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.19 kDa and the accession number is NP_032328.2. | |||
TMPH-01429 |
HSP90AA1 Protein, Human, Recombinant (His)
|
Human | E. coli |
HSP90AA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.0 kDa and the accession number is P07900. | |||
TMPY-06845 |
HSP90 alpha Protein, Human, Recombinant (His)
EL52,HSP89A,heat shock protein 90kDa alpha (cytosolic), clas... |
Human | Baculovirus Insect Cells |
HSP90 alpha Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.06 kDa and the accession number is NP_005339.3. | |||
TMPH-01430 |
HSP90AB1 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
HSP90AB1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 88.1 kDa and the accession number is P08238. | |||
TMPH-03113 |
HSP90AA1 Protein, Pig, Recombinant (His)
|
Sus scrofa (Pig) | Baculovirus Insect Cells |
HSP90AA1 Protein, Pig, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 19.7 kDa and the accession number is O02705. |