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Search Results for " niacin "

13

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19861	Niceritrol Perycit,Cardiolipol,戊四烟酯,Bufor	Others	Others
	Niceritrol (Cardiolipol) 是一种烟酸酯，可降低总血浆以及 VLD 和 LD 脂蛋白部分中的胆固醇和甘油三酯。
T2554	Etofibrate	Others	Others
	Etofibrate 是烟酸和氯贝酸的醚二醇-1,2 二酯。它是动物和人类中一种有效的降血脂剂。
T19700	IBC 293 IBC293,1-异丙基-1H-1,2,3-苯并噻唑-5-羧酸,IBC-293	GPR	Endocrinology/Hormones; GPCR/G Protein
	IBC 293 对 GPR109B 的选择性高于烟酸受体 GPR109A。 IBC 293 是 GPR109B 的高选择性激动剂，GPR109B 是一种在脂肪细胞中表达的人类孤儿 G 蛋白偶联受体。
T25867	Nicodan Percutan Nicotinic acid, propyl ester,Propylnicotinat,烟酸丙酯,Propyl pyridine-3-carboxylate,n-Propyl nicotinate,NSC-78447,NSC 78447,NSC78447	Others	Others
	Nicodan Percutan (Propylnicotinat) 是烟酸的丙酯形式，烟酸在各种动物和植物组织中存在，用于形成辅酶NAD 和NADP。
T1366	3-Pyridylacetic acid hydrochloride	DPP-4	Proteases/Proteasome
	3-Pyridylacetic acid hydrochloride （3-PAA-HCl）尼克酸的高同系物，是尼古丁（和其它烟草生物碱）的分解产物，还可与胺、醇和羧酸等反应，也可在反应中作为酸催化剂。
T1162	Acipimox Olbemox,K-9321,阿西莫司,阿昔莫司	Others	Others
	Acipimox (K-9321) 是烟酸类似物，能够急性抑制脂解作用，抑制全身游离脂肪水平，改善胰岛素敏感性。
T24532	Nicomol Cholexamine,Cholexamin
	Nicomol is a niacin derivative. It also has antilipidemic activity.
T16322	Nicodicosapent	Others	Others
	Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, H
T72188	Nicotinamide Hydrochloride Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride
	Nicotinamide Hydrochloride 是维生素 B3 或烟酸的一种形式，可抑制SIRT2的体外活性，其EC50值为 2 μM。 Nicotinamide Hydrochloride 可抑制 90% 的黑色素瘤细胞数量，并增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide Hydrochloride 抑制黑色素瘤小鼠的肿瘤生长并提高生存率，可用于黑色素瘤等皮肤癌相关的研究。
T40059	Nicotinamide riboside tartrate
	Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.
T40060	Nicotinamide riboside malate
	Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and provides protection against metabolic abnormalities induced by a high-fat diet. Additionally, Nicotinamide riboside malate mitigates cognitive decline in a genetically modified mouse model of Alzheimer's disease.
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...
T37249	Methylmalonyl-Coenzyme A (sodium salt)
	Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C...

化合物

Cat.No: T19861

Synonym: Perycit,Cardiolipol,戊四烟酯,Bufor

Target: Others

Cat.No: T2554

Target: Others

Cat.No: T19700

Synonym: IBC293,1-异丙基-1H-1,2,3-苯并噻唑-5-羧酸,IBC-293

Target: GPR

Nicodan Percutan

Cat.No: T25867

Synonym: Nicotinic acid, propyl ester,Propylnicotinat,烟酸丙酯,Propyl pyridine-3-carboxylate,n-Propyl nicotinate,NSC-78447,NSC 78447,NSC78447

Target: Others

3-Pyridylacetic acid hydrochloride

Cat.No: T1366

Target: DPP-4

Cat.No: T1162

Synonym: Olbemox,K-9321,阿西莫司,阿昔莫司

Target: Others

Cat.No: T24532

Synonym: Cholexamine,Cholexamin

Cat.No: T16322

Target: Others

Nicotinamide Hydrochloride

Cat.No: T72188

Synonym: Niacinamide Hydrochloride,Nicotinic acid amide Hydrochloride,Niacinamide Hydrochloride ; Nicotinic acid amide Hydrochloride

Nicotinamide riboside tartrate

Cat.No: T40059

Nicotinamide riboside malate

Cat.No: T40060

Nicotinamide-d4

Cat.No: T69395

Methylmalonyl-Coenzyme A (sodium salt)

Cat.No: T37249

Cat. No.	Product Name	Target	Signaling Pathways
T0879	Niacin Vitamin B3,烟酸(维生素B3),Nicotinic acid	Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Niacin (Nicotinic acid)，也称为烟酸和维生素 B3，是一种水溶性必需的 B 族维生素，用于治疗维生素缺乏症以及高脂血症，血脂异常，高甘油三酯血症，并降低心肌梗塞的风险
T0879L	Niacin hydrochloride
	Niacin hydrochloride is a water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is needed by the body for the formation of coenzymes NAD and NADP. It possesses PELLAGRA-curative, vasodilating, and antilipemic properties.
T13795	Nicotinamide riboside	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Nicotinamide riboside 是维生素 B3 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体，增加 NAD+水平并激活SIRT1和SIRT3，可用于研究阿尔茨海默氏病的认知退化。
T6220	Nicotinamide riboside chloride 烟酰胺核糖氯酸盐,烟酰胺核苷	Sirtuin; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nicotinamide riboside Chloride 是维生素 B3 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体，增加 NAD+水平并激活SIRT1和SIRT3，可用于研究阿尔茨海默氏病的认知退化。
T4853	TRIA-662 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate	Others; Endogenous Metabolite	Metabolism; Others
	TRIA-662 (Nicotinamide Chloromethylate) 是内源性代谢产物的一种。
T5233	N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylnicotinamide (Nicotinic Acid Methylamide) 是内源性代谢产物的一种。
T0439	L-Tryptophan (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	L-Tryptophan (Tryptophane) 是一种必需氨基酸，是褪黑素、血清素和维生素B3的前体。
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) 是一种酮类和氨基酸衍生物，具有多种生物功能，包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达，可能被用作评估癌症风险的生物标志物。

天然产物

Cat.No: T0879

Synonym: Vitamin B3,烟酸(维生素B3),Nicotinic acid

Target: Endogenous Metabolite, Autophagy

Niacin hydrochloride

Cat.No: T0879L

Nicotinamide riboside

Cat.No: T13795

Target: Sirtuin

Nicotinamide riboside chloride

Cat.No: T6220

Synonym: 烟酰胺核糖氯酸盐,烟酰胺核苷

Target: Sirtuin, Endogenous Metabolite

Cat.No: T4853

Synonym: 3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate

Target: Others, Endogenous Metabolite

N-Methylnicotinamide

Cat.No: T5233

Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺

Target: Others, Endogenous Metabolite

Cat.No: T0439

Synonym: (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸

Target: Amino Acids and Derivatives, Endogenous Metabolite

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Cat.No: T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸

Target: Others, Endogenous Metabolite

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