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61

抑制剂 & 化合物

2

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Cat. No.	Product Name	Target	Signaling Pathways
T22062	CCG-100602	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子信号转导的特异性抑制剂。它抑制 PC-3 前列腺癌细胞中 RhoA/C 介导的、SRF 驱动的荧光素酶表达，IC50为 9.8 µM。
T11282	FGTI-2734	Transferase	Metabolism
	FGTI-2734 是有效的RAS C-末端法尼基转移酶 (FT) 和香叶烯基转移酶-1 (GGT-1) 抑制剂，IC50s 分别为 250 nM 和 520 nM。它可以阻断 KRAS 的膜定位，从而解决 KRAS 耐药性问题，并抑制突变的 KRAS 胰腺肿瘤。
T31408	DFHBI-1T DFHBI1T,DF-HBI-1T,DF HBI 1T,DFHBI 1T
	DFHBI-1T 是一种可透过细胞膜的 RNA 适配体激活的荧光探针。DFHBI-1T 可以用于活细胞中的 RNA 动态定位成像。
T26078	Rhodblock 6 Rhodblock6,Rhodblock-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Rhodblock 6 是一种 Rho 激酶 (ROCK) 抑制剂，可抑制磷酸化 MRLC（肌球蛋白调节轻链）定位,通过特异性抑制 Rho 激酶的活性发挥作用。
T9782	Cytochrome C	Others	Others
	Cytochrome C 是一种属于 c 型细胞色素家族 1 类的蛋白质，根据其细胞定位和其工作条件发挥不同的功能。
T61355	APX2039 APX-2039,APX 2039	Antifungal	Microbiology/Virology
	APX2039 是一种口服有效的真菌 Gwt1 酶 (fungal Gwt1 enzyme) 抑制剂，是新型Gwt2096抑制剂APX1的前药。APX2039 对 C. neoformans 和 C. gattii 展现出极强的抗氪球菌活性。APX2039 具有有效的抗真菌活性，科阻断 GPI (糖基磷脂酰肌醇)锚定细胞壁甘露蛋白的定位。APX2039 可用于研究隐球菌脑膜炎 (CM) 。
TP1653L	SV40 T-Ag-derived NLS peptide acetate SV40 T-Ag-derived NLS peptide acetate(105425-98-7 free base)	Others	Others
	SV40 T-Ag-derived NLS peptide acetate (SV40 T-Ag-derived NLS peptide acetate)(105425-98-7 free base) 是一种核定位信号肽。用这种肽标记的 DNA 可以有效地转移到细胞核中。
T40130	Nur77 modulator 1 Nur77 modulator 1	Others	Others
	Nur77 modulator 1 可与Nur77结合，KD 为 3.58 μM。它上调 Nur77 表达，介导Nur77亚细胞定位，诱导Nur77 依赖的内质网应激和自噬，可导致细胞凋亡，Nur77 modulator 1显示出抗肝癌生物活性。
T27612	INI-43 INI 43,INI43	Others	Others
	INI-43 是Nuclear Import-43 的抑制剂，通过靶向 Kpnβ1 对各种宫颈和食管癌细胞系显示出显着的细胞毒性作用，并干扰 Kpnβ1 和已知的 Kpnβ1 cargo 蛋白、NFAT、NFκB、AP-1和NFY 的核定位。
T69141	NSC1008
	NSC1008 is an inhibitor of the Ras Converting Enzyme 1 (Rce1) protease that disrupts Ras membrane localization in human cells.
T16941	Stauprimide	Others	Others
	Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.
T61328	CO delivery molecule 1
	CO delivery molecule 1 (compound 4) exhibits subcellular localization in the endoplasmic reticulum, mitochondria, and lysosomes. Such localization leads to the manifestation of CO-induced toxicity effects. Notably, the anti-inflammatory properties of CO delivery molecule 1, quantified through TNF-α suppression, are evident at nanomolar concentrations even without CO release. Furthermore, visible-light-induced CO release further enhances its anti-inflammatory effects [1].
TP1653	SV40 T-Ag-derived NLS peptide
	This peptide, a nuclear localization signal DNA tagged to this peptide efficiently translocates into the cell nucleus.
T26342	YH16899 YH-16899,YH 16899,BC-K-YH16899
	YH16899 is a KRS-67LR interaction inhibitor by directly blocking the association between KRS and 67LR, suppressing the dynamic movement of the N-terminal extension of KRS and reducing membrane localization of KRS.
T78448	TPPS	Others	Others
	TPPS是一种无细胞毒性的化合物，用于检测肿瘤位置的探针。
TP1520	Hepatitis B Virus Core (128-140) Hepatitis B Virus Core 128-140
	The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during the cell cycle.
T11282L	FGTI-2734 mesylate (1247018-19-4 free base) FGTI-2734 mesylate	Others	Others
	FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
T36959	BODIPY 558/568 C12 Red C12
	BODIPY 558/568 C12 is a fatty acid-conjugated fluorescent probe for lipid droplets. [1] [2] It displays excitation/emission maxima of 558/568 nm, respectively, and has been used to monitor the localization and dynamics of lipid droplets in live cells.
T82878	Biotin-KKKRKV acetate
	Biotin-KKKRKV acetate为一种生物素化KKKRKV acetate，其中KKKRKV作为源自猴病毒40的核定位信号(NLS)肽。
T39936	HM Janelia Fluor® 526, SE HM-JF526 NHS
	HM Janelia Fluor 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 label showed spontaneous blinking behavior throughout the imaging session and did not require short-wavelength activation light.
T78990	Biotin-labeled ODN 1018 sodium
	Biotin-labeled ODN 1018 (sodium) 为TLR9激动剂，能借助生物素检测系统与光学显微镜评估CpG ODN在细胞内摄取及其定位。
T72397	PARP11 inhibitor ITK7 ITK7
	PARP11 inhibitor ITK7 (ITK7) 为高效选择性的PARP11抑制剂，IC50为14 nM，主要用于针对PARP11的细胞定位研究。
T39243	Janelia Fluor® 585, SE JF585, SE,JF585,NHS
	Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments.
T72504	Aurora Kinases-IN-3
	Aurora Kinases-IN-3 是一种具有口服活性的AURKB 抑制剂，通过破坏 AURKB 的有丝分裂定位，而不是抑制其在 Ser10 位点 H3 的磷酸化，从而诱导 AURKB 抑制活性。
T78999	Biotin-labeled ODN 2395 sodium
	Biotin-labeled ODN 2395 (sodium) 是一类C型CpG ODN并且作为TLR9激动剂。该化合物的细胞内摄取及其在细胞内的定位可通过生物素检测系统结合光学显微技术进行评估。
T78993	Biotin-labeled ODN 1668 sodium
	Biotin-labeled ODN 1668 (sodium) 为B类CpG ODN，充当TLR9激动剂。该化合物的细胞内摄取与位置可利用生物素检测系统及光学显微镜进行评估。
T78662	Biotin-labeled Agatolimod sodium
	Biotin-labeled Agatolimod (sodium) 为B类CpG ODN，兼具TLR9激动剂功能。该化合物通过生物素检测系统与光学显微镜，用于评估CpG ODN的细胞内摄取及定位。
T78664	Biotin-labeled ODN 1826 sodium
	Biotin-labeled ODN 1826 (sodium) 为B类CpG ODN及TLR9激动剂。该化合物利用生物素检测系统与光学显微镜评估CpG ODN的细胞内摄取及定位。
T62406	Nur77 modulator 2
	Nur77 modulator 2 是一种 Nur77 调节剂，其 Kd 值为 0.35 μM。Nur77 modulator 2 也是一种有效的、口服具有活力的炎症抑制剂。Nur77 modulator 2 能够调节 Nur77 在线粒体中的共定位。
T78995	Biotin-labeled ODN 2088 sodium
	Biotin-labeled ODN 2088 (sodium) 作为TLR3、TLR7和TLR9的抑制剂，用于评估CpG ODN在细胞中的摄取与定位，可通过生物素检测系统及光学显微镜进行检测。
T78089	FITC-labeled ODN 1018 sodium
	FITC-labeled ODN 1018 (sodium) 作为TLR9激动剂，其细胞内摄取和定位可通过共聚焦激光扫描显微镜（激发/发射光波长：495/520 nm）或流式细胞术进行评估。
T78991	Biotin-labeled ODN 1585 sodium
	Biotin-labeled ODN 1585 (sodium) 作为一种有效的IFN和TNFα产生诱导剂，能够通过生物素检测系统与光学显微镜评估CpG ODN在细胞内的摄取与定位。
T78997	Biotin-labeled ODN 2216 sodium
	Biotin-labeled ODN 2216 (sodium) 作为TLR9激动剂，其功能在于通过生物素检测系统及光学显微镜评估CpG ODN的细胞内摄取与位置定位。
T78992	FITC-labeled ODN 1585 sodium
	FITC-labeled ODN 1585 (sodium) 为B类CpG ODN同时兼作TLR9激动剂。通过共聚焦激光扫描显微镜(激发/发射光波长：495/520 nm)或流式细胞术，可评估其细胞内摄取和定位情况。
T78998	FITC-labeled ODN 2216 sodium
	FITC-labeled ODN 2216 (sodium) 为TLR9激动剂，其细胞摄取与定位可通过共聚焦激光扫描显微镜（激发/发射光波长：495/520 nm）或流式细胞术评估。
T79000	FITC-labeled ODN 2395 sodium
	FITC-labeled ODN 2395 (sodium) 是C类CpG ODN，具有TLR9激动剂功能。该化合物的细胞摄取和定位可通过共聚焦激光扫描显微镜（激发/发射光波长：495/520 nm）或流式细胞术进行评估。
T79001	Biotin-labeled ODN TTAGGG sodium
	Biotin-labeled ODN TTAGGG (sodium) 作为TLR9、AIM2及cGAS拮抗剂的抑制性寡核苷酸，通过生物素检测系统及光学显微技术可评估CpG ODN在细胞内的摄取与定位。
T83343	3x DYKDDDDK Tag
	3x DYKDDDDK Tag 作为研究Abs时无法使用的蛋白质功能与定位的工具而得到应用。它经常以3x标志形式（3x DYKDDDDK Tag TFA）用于纯化低丰度蛋白。
T78534	NVOC cage-TMP-Halo	Others	Others
	NVOC cage-TMP-Halo是一种具有细胞渗透能力和光激活特性的蛋白质二聚化诱导剂。该化合物可对活细胞内蛋白质定位进行快速且可逆的控制，适用于研究动态细胞过程。
T36863	Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
	Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco...
T78665	FITC-labeled ODN 1826 sodium
	FITC-labeled ODN 1826（sodium）为B类CpG ODN，兼作TLR9激动剂。该化合物的细胞摄取和定位可通过共聚焦激光扫描显微镜（激发/发射光波长：495/520 nm）及流式细胞术进行评估。
T81305	ReAsH-EDT2
	ReAsH-EDT2为膜透性红色荧光染料，专用于蛋白质标记。作为二砷化合物，其通过共价结合至四半胱氨酸序列实现蛋白质成像，并可监测其定位与转运。(λex=530 nm，λem=592 nm)。
T78996	FITC-labeled ODN 2088 sodium
	FITC-labeled ODN 2088 (sodium) 作为TLR3、TLR7和TLR9的抑制剂，可用于评估CpG ODN在细胞内的摄取与定位。通过共聚焦激光扫描显微镜（激发/发射光波长：495/520 nm）或流式细胞术进行检测。
T78663	FITC-labeled Agatolimod sodium
	FITC-labeled Agatolimod (sodium) 是一种B类CpG ODN，兼具TLR9激动剂功能。该化合物应用共聚焦激光扫描显微镜(激发/发射光波长：495/520 nm)或流式细胞术，可以评估CpG ODN在细胞内的摄取及定位情况。
T79002	FITC-labeled ODN TTAGGG sodium
	FITC-labeled ODN TTAGGG (sodium) 作为一种寡核苷酸抑制剂，对TLR9、AIM2及cGAS具有拮抗作用。通过共聚焦激光扫描显微镜（激发/发射光波长：495/520 nm）或流式细胞术，可以评估CpG ODN在细胞内的摄取及定位情况。
T63980	BODIPY FL prazosin
	BODIPY FL prazosin 是荧光 α1-肾上腺素 α1-adrenergic 拮抗剂，能够作用于 α1a-AR (Ki: 14.5 nM)和 α1b-AR (Ki: 43.3 nM)。BODIPY FL prazosin 是一种荧光配体，激发和发射波长分别为 485 和 535 nm。BODIPY FL prazosin 能够用于 α1-肾上腺素受体亚型的亚细胞定位差异的研究。
T38153	NF-κB Inhibitor (trifluoroacetate salt)
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
T78994	FITC-labeled ODN 1668 sodium
	FITC-labeled ODN 1668 (sodium) 是B类CpG ODN，兼具TLR9激动剂功能。该化合物能借助共聚焦激光扫描显微镜(激发/发射光波长：495/520 nm)及流式细胞术，用于评估CpG ODN在细胞内的摄取及定位情况。
T78528	ERX-41	Others	Others
	ERX-41是一种口服活性的立体特异性小分子，靶向溶酶体酸性脂肪酶A (LIPA)。该化合物通过诱导内质网(ER)应激从而导致细胞死亡，这一作用表明ERX-41功能独立于LIPA，但依赖于其在内质网的定位。ERX-41主要用于实体瘤靶向研究。
T37559	NF-κB Control
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α. NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids...

化合物

Cat.No: T22062

Target: Rho, Ras

Cat.No: T11282

Target: Transferase

Cat.No: T31408

Synonym: DFHBI1T,DF-HBI-1T,DF HBI 1T,DFHBI 1T

Cat.No: T26078

Synonym: Rhodblock6,Rhodblock-6

Target: ROCK

Cat.No: T9782

Target: Others

Cat.No: T61355

Synonym: APX-2039,APX 2039

Target: Antifungal

SV40 T-Ag-derived NLS peptide acetate

Cat.No: TP1653L

Synonym: SV40 T-Ag-derived NLS peptide acetate(105425-98-7 free base)

Target: Others

Nur77 modulator 1

Cat.No: T40130

Synonym: Nur77 modulator 1

Target: Others

Cat.No: T27612

Synonym: INI 43,INI43

Target: Others

Cat.No: T69141

Cat.No: T16941

Target: Others

CO delivery molecule 1

Cat.No: T61328

SV40 T-Ag-derived NLS peptide

Cat.No: TP1653

Cat.No: T26342

Synonym: YH-16899,YH 16899,BC-K-YH16899

Cat.No: T78448

Target: Others

Hepatitis B Virus Core (128-140)

Cat.No: TP1520

Synonym: Hepatitis B Virus Core 128-140

FGTI-2734 mesylate (1247018-19-4 free base)

Cat.No: T11282L

Synonym: FGTI-2734 mesylate

Target: Others

BODIPY 558/568 C12

Cat.No: T36959

Synonym: Red C12

Biotin-KKKRKV acetate

Cat.No: T82878

HM Janelia Fluor® 526, SE

Cat.No: T39936

Synonym: HM-JF526 NHS

Biotin-labeled ODN 1018 sodium

Cat.No: T78990

PARP11 inhibitor ITK7

Cat.No: T72397

Synonym: ITK7

Janelia Fluor® 585, SE

Cat.No: T39243

Synonym: JF585, SE,JF585,NHS

Aurora Kinases-IN-3

Cat.No: T72504

Biotin-labeled ODN 2395 sodium

Cat.No: T78999

Biotin-labeled ODN 1668 sodium

Cat.No: T78993

Biotin-labeled Agatolimod sodium

Cat.No: T78662

Biotin-labeled ODN 1826 sodium

Cat.No: T78664

Nur77 modulator 2

Cat.No: T62406

Biotin-labeled ODN 2088 sodium

Cat.No: T78995

FITC-labeled ODN 1018 sodium

Cat.No: T78089

Biotin-labeled ODN 1585 sodium

Cat.No: T78991

Biotin-labeled ODN 2216 sodium

Cat.No: T78997

FITC-labeled ODN 1585 sodium

Cat.No: T78992

FITC-labeled ODN 2216 sodium

Cat.No: T78998

FITC-labeled ODN 2395 sodium

Cat.No: T79000

Biotin-labeled ODN TTAGGG sodium

Cat.No: T79001

3x DYKDDDDK Tag

Cat.No: T83343

NVOC cage-TMP-Halo

Cat.No: T78534

Target: Others

Geranylgeranyl Pyrophosphate (ammonium salt)

Cat.No: T36863

Synonym: Geranylgeranyl Pyrophosphate (ammonium salt),GGPP

FITC-labeled ODN 1826 sodium

Cat.No: T78665

Cat.No: T81305

FITC-labeled ODN 2088 sodium

Cat.No: T78996

FITC-labeled Agatolimod sodium

Cat.No: T78663

FITC-labeled ODN TTAGGG sodium

Cat.No: T79002

BODIPY FL prazosin

Cat.No: T63980

NF-κB Inhibitor (trifluoroacetate salt)

Cat.No: T38153

FITC-labeled ODN 1668 sodium

Cat.No: T78994

Cat.No: T78528

Target: Others

Cat.No: T37559

Cat. No.	Product Name	Target	Signaling Pathways
T2856	(-)-Epicatechin L-Epicatechin,表儿茶素,Epicatechin,(-)-Epicatechol,表儿茶精	Ferroptosis; COX; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	(-)-Epicatechin (Epicatechin) 是一种 COX-1 的抑制剂，通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达。
T19229	Catalase	Others	Others
	Catalase 是重要的抗氧化酶,在清除 ROS 及维持氧化还原状态的平衡方面发挥着重要作用。Catalase 与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。

天然产物

(-)-Epicatechin

Cat.No: T2856

Synonym: L-Epicatechin,表儿茶素,Epicatechin,(-)-Epicatechol,表儿茶精

Target: Ferroptosis, COX, Endogenous Metabolite

Cat.No: T19229

Target: Others

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