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Search Results for " leishmaniasis "

13

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12137	N-(2-Hydroxypropyl)methacrylamide	Parasite	Microbiology/Virology
	N-(2-Hydroxypropyl)methacrylamide 用于合成共聚物，用于靶向递送内脏利什曼病中的抗寄生虫剂。
T0891	Dapsone DDS,4,4‘-Sulfonyldianiline,氨苯砜,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone	Reactive Oxygen Species; Antibacterial; Antibiotic; Parasite	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Dapsone (Sulphadione) 是具有口服活性和血脑渗透通透性的磺酰类抗生素，具有抑菌、抗细菌和抗原虫活性。它有抗麻风活性，抑制麻风杆菌细胞提取物中叶酸的合成。它可研究皮肤病。
T39746	DNDI-6148
	DNDI-6148 is a novel preclinical candidate for the treatment of visceral leishmaniasis.
T0033	Miltefosine HePC,米替福新,Hexadecyl phosphocholine	Akt; HIV Protease; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Miltefosine (HePC) 是一种广谱抗微生物剂，是治疗内脏和皮肤利什曼病的药物。它是 CTP 磷酸胆碱胞苷基转移酶的抑制剂。
T39214L	LXE408 fumarate LXE408 fumarate (1799330-15-6 Free base)	Proteasome	Proteases/Proteasome; Ubiquitination
	LXE408 fumarate 是一种口服有效的，非竞争性的，动素体选择性蛋白酶体 (proteasome) 抑制剂。LXE408 fumarate 抑制 L. donovani 蛋白酶体 (IC50=0.04 μM) 和 L. donovani (EC50=0.04 μM)。LXE408 fumarate 具有较弱的透过血脑屏障能力。LXE408 fumarate 具有用于内脏利什曼病 (VL) 研究的潜力。
T29991	Aminoquinol triphosphate Aminochinol triphosphate
	Aminoquinol triphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.
T29990	Aminoquinol diphosphate
	Aminoquinol diphosphate may be useful in the treatment of acute necrotising cutaneous leishmaniasis.
T23783	Benzoxonium chloride Bradophen,Bialcol,D 301,D301,Cohortan
	Benzoxonium chloride, The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy.
T39214	LXE408 LXE408
	LXE408 is an orally active, kinetoplastid-selective proteasome inhibitor, exhibiting non-competitive inhibitory effects. It demonstrates an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. Moreover, LXE408 shows limited ability to traverse the blood-brain barrier. Hence, LXE408 holds promise for advancing research in the field of visceral leishmaniasis (VL).
T62362	GNF6702
	GNF6702 是一种选择性的动质体蛋白酶体 (kinetoplastid proteasome) 抑制剂。GNF6702 对利什曼病、南美锥虫病和人类非洲锥虫病小鼠模型中的寄生虫具有清除作用。
T64056	Trypanothione synthetase-IN-4
	Trypanothione synthetase-IN-4 是一个 L. infantumTryS 抑制剂，其活性依赖于多胺底物的浓度。Trypanothione synthetase-IN-4 表现出较强的抗 leishmanicidal 效果 (EC50: 0.6 μM，SI (选择性指数): 35）。Trypanothione synthetase-IN-4 能够用于研究利什曼病。
T60836	PT4
	PT4 可治疗皮肤利什曼病 (CL) ，它通过降低线粒体膜电位并增加活性氧的产生，从而寄生虫死亡。PT4 对两种利什曼原虫均产生效果，其对L. amazonensis 和L. braziliensis 的 IC50值分别为 125.18 和 233.18 μM。PT4 同时在体内具有有效的抗炎活性。
T65387	Paromomycin, sulfate (1:1)
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10...

化合物

N-(2-Hydroxypropyl)methacrylamide

Cat.No: T12137

Target: Parasite

Cat.No: T0891

Synonym: DDS,4,4‘-Sulfonyldianiline,氨苯砜,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone

Target: Reactive Oxygen Species, Antibacterial, Antibiotic, Parasite

Cat.No: T39746

Cat.No: T0033

Synonym: HePC,米替福新,Hexadecyl phosphocholine

Target: Akt, HIV Protease, PKC

LXE408 fumarate

Cat.No: T39214L

Synonym: LXE408 fumarate (1799330-15-6 Free base)

Target: Proteasome

Aminoquinol triphosphate

Cat.No: T29991

Synonym: Aminochinol triphosphate

Aminoquinol diphosphate

Cat.No: T29990

Benzoxonium chloride

Cat.No: T23783

Synonym: Bradophen,Bialcol,D 301,D301,Cohortan

Cat.No: T39214

Synonym: LXE408

Cat.No: T62362

Trypanothione synthetase-IN-4

Cat.No: T64056

Cat.No: T60836

Paromomycin, sulfate (1:1)

Cat.No: T65387

Cat. No.	Product Name	Target	Signaling Pathways
TN4660	Niranthin	Anti-infection; HBV; PAFR; Topoisomerase	DNA Damage/DNA Repair; GPCR/G Protein; Microbiology/Virology
	Niranthin 是一种木脂素，具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂，可用于研究耐药利什曼病的治疗。
T1104	Paromomycin Sulfate Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素，是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。它可研究细菌和寄生虫感染。
TN4470	Lyoniside	Antifection	Microbiology/Virology
	Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The
TN3568	Calceolarioside A	Calcium Channel; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi

天然产物

Cat.No: TN4660

Target: Anti-infection, HBV, PAFR, Topoisomerase

Paromomycin Sulfate

Cat.No: T1104

Synonym: Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐

Target: Antibacterial, Antibiotic, Parasite

Cat.No: TN4470

Target: Antifection

Calceolarioside A

Cat.No: TN3568

Target: Calcium Channel, Antifection

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