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Cat. No.	Product Name	Target	Signaling Pathways
T73611	Kallikrein
	Kallikrein 能够在血浆和组织中形成激肽释放酶激肽系统（KKS)，分别产生缓激肽和激肽肽。
T40312	Plasma kallikrein-IN-1
	Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM.
T63579	Kallikrein-IN-1
	Kallikrein-IN-1 (Formula A) 是一种激肽释放酶 Kallikrein 抑制剂。
T63796	Kallikrein-IN-2
	Kallikrein-IN-2 (compound 1) 是一种激肽释放酶 Kallikrein 的抑制剂。
T72337	Plasma kallikrein-IN-2
	Plasma kallikrein-IN-2 是一个有效的 plasma kallikrein (PKal)抑制剂，IC50值为 0.1 nM。Plasma kallikrein-IN-2 可用于遗传性血管水肿、糖尿病性黄斑水肿、糖尿病视网膜病变的研究。
T72624	Kallikrein 5-IN-2
	Kallikrein 5-IN-2 是一种选择性 KallikreinKLK5抑制剂 (pIC50=7.1)。KLK5 抑制可以使表皮脱落正常化并减少相关的炎症和瘙痒。
T61403	Plasma kallikrein-IN-3
	Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].
T11885	LSP-249	Others	Others
	LSP-249是血浆 kallikrein 的抑制剂，用于血管性水肿的研究，EC50值小于 100 nM。
T14358	Avoralstat BCX4161	Others	Others
	Avoralstat (BCX4161) 是血浆激肽释放酶(PKK)抑制剂，具有口服活性，可用于遗传性血管性水肿的研究。
T3359	Aprotinin 抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others; Serine Protease; Influenza Virus; Proteasome	Microbiology/Virology; Others; Proteases/Proteasome; Ubiquitination
	Aprotinin (Traskolan) 是分离自牛肺的一种广谱丝氨酸蛋白酶抑制剂，可抑制多种不同酯酶和蛋白酶的活性。
T6370	AEBSF hydrochloride AEBSF HCl,Pefabloc SC	Thrombin; Serine Protease; Influenza Virus	Microbiology/Virology; Proteases/Proteasome
	AEBSF hydrochloride (Pefabloc SC) 是一种丝氨酸蛋白酶的不可逆抑制剂。
T39350	Sebetralstat KVD900	Others	Others
	Sebetralstat (KVD900) 是一种血浆激肽释放酶抑制剂，可用于代谢性疾病的研究。
TP1792L	KKI-5 acetate(97145-43-2 free base)	Serine Protease	Proteases/Proteasome
	KKI-5 acetate(97145-43-2 free base) 是一种丝氨酸蛋白酶抑制剂，可抑制激肽释放酶和纤溶酶。 KKI 5 可能表现出抗癌化疗益处，也可用作血管性水肿的治疗方法。
T68173	ZD-2138 Ici-D2138	Lipoxygenase	Metabolism
	ZD-2138是一种有效且具有选择性的5-脂氧合酶（5-LOX）的特异性抑制剂，抑制了过敏原诱导的肺支气管收缩，可减少豚鼠孤立气道的神经诱发性快速激肽能收缩。ZD-2138可用来治疗哮喘疾病。
T0372	Gabexate mesylate 甲磺酸加贝酯,FOY	Factor Xa; Serine Protease; Proteasome	Metabolism; Proteases/Proteasome; Ubiquitination
	Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
T21610	Bradykinin (acetate)	Bradykinin Receptor	GPCR/G Protein
	Bradykinin (acetate) 是一种由激肽释放酶-激肽系统产生的活性肽。它是一种炎症介质，也被认为是多种血管和肾功能的神经介质和调节剂。它由血液中的 kallidin 酶促产生，是一种强大的血管扩张剂，可引起平滑肌收缩，并可能介导炎症。它具有作为人血清代谢物和血管扩张剂的作用。它是缓激肽 (2+) 的互变异构体。
T70161	Berotralstat HCl
	Berotralstat HCl is a novel selective inhibitor of plasma kallikrein, blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE.
T37033	H-D-Pro-Phe-Arg-pNA . 2 HCl
	pFR-pNA, chromogenic substrate for the determination of plasma kallikrein-like activity. CAS Number (net): 64816-19-9.
T82510	Ecallantide TFA DX-88 TFA
	Ecallantide (DX-88) TFA 是一种特异性的重组血浆激肽释放酶(Kallikrein)抑制剂，作用于缓激肽的生成过程以减少其产生。此化合物主要用于预防和治疗血管性水肿的急性攻击。
T71417	LM-030
	LM-030, also known as BPR277, is a novel inhibitor of kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2).
T80271	Irucalantide
	Irucalantide 是一种激肽释放酶（kallikrein）抑制剂，能够阻碍这种酶的活性，从而影响相关的生物过程。
T35579	PKSI-527
	PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of in...
T77999	KKI-5 TFA
	KKI-5 (TFA)为特异性组织激肽释放酶抑制剂，能有效减少乳腺癌细胞的浸润性。
T63507	Feniralstat
	Feniralstat 是吡唑衍生物，是一种激肽释放酶 (kallikrein) 的有效抑制剂，能够抑制人血浆激肽释放酶 (pKal) (IC50: 6.7 nM)。Feniralstat 不抑制人 KLK1、人 FXIa 和人因子 Xlla (IC50均 >40 μM)。
TP1379	KKI-5 TFA(97145-43-2 free base) KKI-5 (TFA)
	KKI-5 (TFA) is a specific tissue kallikrein inhibitor.Kki-5 (TFA) can reduce breast cancer cell infiltration.
T35869	Berotralstat
	Berotralstat (BCX7353) is a second-generation, synthetic, and orally active plasma kallikrein inhibitor with low toxicity. It is highly specific and effectively used in the research of hereditary angioedema (HAE) attacks. Berotralstat functions by inhibiting the enzymatic activity of plasma kallikrein, which is responsible for the release of bradykinin. This blocking mechanism targets the major biologic peptide involved in the promotion of swelling and pain associated with HAE attacks[1][2].
TP1013	N-CBZ-Phe-Arg-AMC Z-FR-AMC
	N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a substrate for serine proteases, including cathepsins, kallikrein and plasmin. Absorption/emission of substrate = 330/390 nm (weak fluorescence); absorption/emission of end product (AMC) = 342/441 nm (strong fluorescence).
T80095	D-Pro-Phe-Arg-Chloromethylketone	Factor Xa	Metabolism
	D-Pro-Phe-Arg-Chloromethylketone是一种抑制剂，它针对凝血因子XII (coagulation factor XII) 和血浆激肽释放酶 (kallikrein)，在血栓形成和炎症过程中具有关键作用。
T69777	DKFZ-251
	DKFZ-251 is a potent inhibitor of kallikrein-related peptidase 6 with on-target cellular activity. DKFZ-251 demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay.
T78572	Ecallantide DX-88
	Ecallantide (DX-88) 是高特异性重组血浆激肽释放酶抑制剂，用于阻断缓激肽生成，治疗血管性水肿急性发作。
TP1792	KKI-5
	KKI 5 is a serine protease inhibitor that inhibits kallikrein and plasmin. KKI 5 may exhibit anticancer chemotherapeutic benefit and may also be used as a treatment for angioedema.
T6564L	Leupeptin Leupeptin Ac-LL,NK-381
	Leupeptin is a competitive protease inhibitor produced by actinomycetes. Leupeptin can inhibit cysteine, serine and threonine peptidases. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine p
T69297	Leupeptin HCl
	Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. Leupeptin is a competitive transition state inhibitor and its inhibition may be relieved by...
T76248	Tutuilamide A
	Tutuilamide A为一有效抑制剂，针对猪胰弹性蛋白酶(PPE)展现出1.2 nM的IC50值。此外，该化合物亦对人中性粒细胞弹性蛋白酶(HNE; IC50=0.73 nM)及激肽释放酶7(KLK7; IC50=5.0 nM)有抑制作用。
T76710	Lanadelumab
	Lanadelumab (SHP643) 是一种针对血浆激肽释放酶 (plasma kallikrein (pKal)) 的人源化IgG1单克隆抗体，Ki 值为 0.12 nM。Lanadelumab 抑制游离和 HMWK 结合的 pKal。Lanadelumab 具有研究遗传性血管性水肿的潜力
T70170	Milvexian TFA
	Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%.

化合物

Cat.No: T73611

Plasma kallikrein-IN-1

Cat.No: T40312

Kallikrein-IN-1

Cat.No: T63579

Kallikrein-IN-2

Cat.No: T63796

Plasma kallikrein-IN-2

Cat.No: T72337

Kallikrein 5-IN-2

Cat.No: T72624

Plasma kallikrein-IN-3

Cat.No: T61403

Cat.No: T11885

Target: Others

Cat.No: T14358

Synonym: BCX4161

Target: Others

Cat.No: T3359

Synonym: 抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin

Target: Others, Serine Protease, Influenza Virus, Proteasome

AEBSF hydrochloride

Cat.No: T6370

Synonym: AEBSF HCl,Pefabloc SC

Target: Thrombin, Serine Protease, Influenza Virus

Cat.No: T39350

Synonym: KVD900

Target: Others

KKI-5 acetate(97145-43-2 free base)

Cat.No: TP1792L

Target: Serine Protease

Cat.No: T68173

Synonym: Ici-D2138

Target: Lipoxygenase

Gabexate mesylate

Cat.No: T0372

Synonym: 甲磺酸加贝酯,FOY

Target: Factor Xa, Serine Protease, Proteasome

Bradykinin (acetate)

Cat.No: T21610

Target: Bradykinin Receptor

Berotralstat HCl

Cat.No: T70161

H-D-Pro-Phe-Arg-pNA . 2 HCl

Cat.No: T37033

Ecallantide TFA

Cat.No: T82510

Synonym: DX-88 TFA

Cat.No: T71417

Cat.No: T80271

Cat.No: T35579

Cat.No: T77999

Cat.No: T63507

KKI-5 TFA(97145-43-2 free base)

Cat.No: TP1379

Synonym: KKI-5 (TFA)

Cat.No: T35869

N-CBZ-Phe-Arg-AMC

Cat.No: TP1013

Synonym: Z-FR-AMC

D-Pro-Phe-Arg-Chloromethylketone

Cat.No: T80095

Target: Factor Xa

Cat.No: T69777

Cat.No: T78572

Synonym: DX-88

Cat.No: TP1792

Cat.No: T6564L

Synonym: Leupeptin Ac-LL,NK-381

Cat.No: T69297

Cat.No: T76248

Cat.No: T76710

Cat.No: T70170

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