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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T23312	SB 204741	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 204741 是一种选择性的5-HT2B 拮抗剂，具有高亲和性，pKi 值为7.1。
T26822	Bisaramil hydrochloride RGH-2957,NK 1556,NK1556,Bisaramil,NK-1556,RGH 2957	Potassium Channel; Adrenergic Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Bisaramil hydrochloride (Bisaramil) 是一种新型二氮双环壬烷抗心律失常化合物，抑制自由基生成。Bisaramil hydrochloride 可阻断钠电流，抑制异丙肾上腺素在 K（+）去极化肌上诱导的缓慢 Ca（2+）动作电位。
T69598	Isoproterenol-d7 HCl
	Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom...
T37896	AZ 1729
	FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assays, displays positive allosteric modulation of FFA-induced Gi signaling and negative allosteric modulation of FFA-induced Gq/G11 signaling. Inhibits lipolytic effect of isoproterenol (pEC50 = 5.03) and induces migration of human neutrophils in vitro. Bolognini et al (2016) A novel...
T71141	Fenspiride-d5
	Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ...
T36679	Rp-cAMPS sodium salt
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t...

化合物

SB 204741

Cat.No: T23312

Synonym:

Target: 5-HT Receptor

Bisaramil hydrochloride

Cat.No: T26822

Synonym: RGH-2957,NK 1556,NK1556,Bisaramil,NK-1556,RGH 2957

Target: Potassium Channel, Adrenergic Receptor

Isoproterenol-d7 HCl

Cat. No.	Product Name	Target	Signaling Pathways
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。