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21

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0961	Trometamol 三(羟甲基)氨基甲烷,Tromethamine,缓血酸铵	COX	Immunology/Inflammation; Neuroscience
	Trometamol (Tromethamine) 是一种在生理范围内控制 pH 值的有效胺类化合物，也是一种低毒性的生物惰性氨基醇，可以在体内和体外缓冲二氧化碳和酸。
T23478	Trometamol hydrochloride TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐	Others	Others
	Trometamol hydrochloride (TRIS hydrochloride) 是低毒性的生物惰性氨基醇，可以在体内、外缓冲二氧化碳和酸，能用于生理范围内控制 pH 值。
T16034	Meclinertant SR 48692	Others	Others
	Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in human colon carcinoma (HT-29) cell
T19805	Benoxacor BRN-4190275,解草酮,BRN 4190275,BRN4190275	Others	Others
	Benoxacor (BRN-4190275) 是一种惰性农业化学品。它作为一种除草剂安全剂，可保护作物免受除草剂毒性。
TNU0123	5-Methoxyuridine Mo5U	Apoptosis	Apoptosis
	5-Methoxyuridine (Mo5U) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.5-Methoxyuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.5-Methoxyuridine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.
TNU0436	2-Thiocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2-Thiocytidine 是一种靶向惰性淋巴系统恶性肿瘤的嘌呤核苷类似物，具有广泛的抗肿瘤活性。2-Thiocytidine 通过抑制 DNA 合成诱导细胞凋亡 (apoptosis) 。
TNU0022	6-Azauridine 6-Azuridine	Apoptosis	Apoptosis
	6-Azauridine (6-Azuridine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.6-Azuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.
TNU0352	1-beta-D-Arabinofuranosylthymine Thymine 1-β-D-arabinofuranoside,Spongothymidine	Apoptosis	Apoptosis
	1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.
T21017	5'-Amino-5'-deoxyadenosine 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo	Apoptosis; Adenosine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	5'-Amino-5'-deoxyadenosine (NH2dAdo) 是一种针对惰性淋巴系统恶性肿瘤的腺苷激酶抑制剂，具有抗肿瘤和抗癌作用。5'-Amino-5'-deoxyadenosine 的抗癌机制通过抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等来实现。
TNU0168	2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine	Apoptosis	Apoptosis
	Nucleoside Derivatives - Fluoro-modified nucleosides, Arabino-nucleosides, 2’-Modified nucleosides; Drugs and Inhibitors; Anticancer agent; Impurity C of Clofarabine
TNU0839	1,4-Dideoxy-1,4-epithio-D-ribitol	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	1,4-Dideoxy-1,4-epithio-D-ribitol 是一种靶向惰性淋巴系统恶性肿瘤的嘌呤核苷类似物，具有广泛的抗肿瘤活性。1,4-Dideoxy-1,4-epithio-D-ribitol 通过抑制 DNA 合成诱导细胞凋亡 (apoptosis) 。
TNU0630	2'-O-Methyl-5-iodouridine 5-Iodo-2'-O-methyluridine
	2'-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) 是一种靶向惰性淋巴系统恶性肿瘤的嘌呤核苷类似物，具有广泛的抗肿瘤活性。2'-O-Methyl-5-iodouridine 的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 。
T1098	Denatonium benzoate 苯甲地那铵,THS-839	Others	Others
	Denatonium benzoate (THS-839) 是一种已知的最苦的化合物，可作为厌恶剂(苦味剂)，加入到工业酒精、防冻液、咬指甲癖预防、呼吸器面罩配合测试、动物驱虫剂、液体皂和洗发水中，防止不适当的摄取。
T40973	MDNI-caged-L-glutamate MDNI-caged-L-glutamate,MDNI-glu
	MDNI-glu is a photosensitive derivative of L-glutamate, a major excitatory amino acid, that is biologically inert. It demonstrates improved utilization of incident light.
T39050	Pitnot-2
	Pitnot-2 is an inert analogue of the clathrin inhibitor Pitstop 2, commonly employed as a negative control in experimental studies.
T76984	Tecaginlimab
	Tecaginlimab (BNT-312) 是一种 Fc 惰性双特异性抗体，用于CD40和4-1BB 的双重靶向和条件刺激。Tecaginlimab 可以增强肿瘤特异性免疫的启动和再激活。
T21075	Perfluoro(1,3-dimethylcyclohexane) Cyclohexane, perfluoro-1,3-dimethyl-,Hexadecafluoro-1,3-dimethylcyclohexane,Cyclohexane, decafluoro-1,3-bis(trifluoromethyl)-
	Perfluoro-1,3-dimethylcyclohexane is used as a synthesis reagent for amorphous fluorocarbon film preparation by plasma polymerization, and for the hydroformylation of linear terminal alkenes. As a chemically inert compound, it is similar in properties to
TP1189	C-Peptide, dog C-Peptide (dog)
	C-Peptide, dog is a component of proinsulin, released from pancreatic beta cells into blood together with insulin. The C-peptide of proinsulin is important for the biosynthesis of insulin but has for a long time been considered to be biologically inert.
TNU1041	3’-Deoxy-1,2-O-isopropylidene-5-O-(p-toluoyl)-L-arabinofuranose
	3’-Deoxy-1,2-O-isopropylidene-5-O-(p-toluoyl)-L-arabinofuranose 是一种嘌呤核苷类似物，通过抑制DNA 合成、诱导细胞凋亡发挥抗肿瘤活性，它可以靶向惰性淋巴系统恶性肿瘤。
T77228	Polyoxyethylene Sorbitan Monostearate
	Polyoxyethylene Sorbitan Monostearate 是一种由饱和脂肪酸硬脂酸 (C18:0) 构成的酯，广泛应用作药用辅料，包括表面活性剂、乳化剂、增溶剂和润湿剂。作为药用助剂，其主要作用是改善药物制剂的稳定性、溶解性和加工性，同时对药物的吸收、分布、代谢和消除 (ADME) 过程具有影响。
T38071	HPF
	The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.[1] There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). [2] HPF is a cell-permeable aroma...

化合物

Cat.No: T0961

Synonym: 三(羟甲基)氨基甲烷,Tromethamine,缓血酸铵

Target: COX

Trometamol hydrochloride

Cat.No: T23478

Synonym: TRIS hydrochloride,三(羟甲基)氨基甲烷盐酸盐

Target: Others

Cat.No: T16034

Synonym: SR 48692

Target: Others

Cat.No: T19805

Synonym: BRN-4190275,解草酮,BRN 4190275,BRN4190275

Target: Others

5-Methoxyuridine

Cat.No: TNU0123

Synonym: Mo5U

Target: Apoptosis

Cat.No: TNU0436

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: TNU0022

Synonym: 6-Azuridine

Target: Apoptosis

1-beta-D-Arabinofuranosylthymine

Cat.No: TNU0352

Synonym: Thymine 1-β-D-arabinofuranoside,Spongothymidine

Target: Apoptosis

5'-Amino-5'-deoxyadenosine

Cat.No: T21017

Synonym: 5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo

Target: Apoptosis, Adenosine Receptor

2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine

Cat.No: TNU0168

Target: Apoptosis

1,4-Dideoxy-1,4-epithio-D-ribitol

Cat.No: TNU0839

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

2'-O-Methyl-5-iodouridine

Cat.No: TNU0630

Synonym: 5-Iodo-2'-O-methyluridine

Denatonium benzoate

Cat.No: T1098

Synonym: 苯甲地那铵,THS-839

Target: Others

MDNI-caged-L-glutamate

Cat.No: T40973

Synonym: MDNI-caged-L-glutamate,MDNI-glu

Cat.No: T39050

Cat.No: T76984

Perfluoro(1,3-dimethylcyclohexane)

Cat.No: T21075

Synonym: Cyclohexane, perfluoro-1,3-dimethyl-,Hexadecafluoro-1,3-dimethylcyclohexane,Cyclohexane, decafluoro-1,3-bis(trifluoromethyl)-

Cat.No: TP1189

Synonym: C-Peptide (dog)

3’-Deoxy-1,2-O-isopropylidene-5-O-(p-toluoyl)-L-arabinofuranose

Cat.No: TNU1041

Polyoxyethylene Sorbitan Monostearate

Cat.No: T77228

Cat.No: T38071

Cat. No.	Product Name	Target	Signaling Pathways
TNU0052	Nebularine 9-(beta-D-Ribofuranosyl)-9H-purine	Apoptosis	Apoptosis
	Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine)，是一种嘌呤核苷类似物，具有广谱的抗肿瘤活性，针对惰性淋巴恶性肿瘤并诱导凋亡。Nebularine的抗癌机制依赖于抑制DNA合成。
T41358	2-Hydroxybenzylamine	Others	Others
	2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂，可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。

天然产物

Cat.No: TNU0052

Synonym: 9-(beta-D-Ribofuranosyl)-9H-purine

Target: Apoptosis

2-Hydroxybenzylamine

Cat.No: T41358

Target: Others

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