271
6
Cat. No. | Product Name | Target | Signaling Pathways |
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T1698 |
Carvedilol EP IMpurity E
Carvedilol USP E,Carvedilol Impurity E,卡维地洛杂质 |
Others | Others |
Carvedilol EP IMpurity E (Carvedilol USP E) 用作药物中间体。 | |||
T1733 |
Ciprofloxacin EP IMpurity A
Q-Acid,Fluoroquinolonic Acid,环丙羧酸,Ciprofloxacin Impurity A |
Antibiotic | Microbiology/Virology |
Ciprofloxacin EP IMpurity A (Fluoroquinolonic Acid) 是一种抗生素和抗菌剂。 | |||
T8752 |
BAR 501 impurity
|
GPCR19 | GPCR/G Protein |
BAR 501 impurity 在 BAR501 制剂中发现的一种杂质,可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。 | |||
T31204 | Darapladib-impurity | Others | Others |
Darapladib-impurity 是 Darapladib 的杂质。Darapladib 对脂蛋白相关磷脂酶 A2 (Lp-PLA2)有抑制作用。 | |||
T11007L |
Levofloxacin Hydrochloride Impurity A
Levofloxacin Hydrochloride Impurity A(117707-40-1 Free base),左氧氟沙星杂质A(盐酸盐) |
Antibacterial | Microbiology/Virology |
Levofloxacin Hydrochloride Impurity A 是一种喹诺酮类药物,具有广谱抗菌作用。 | |||
T9042 |
Teriflunomide impurity 3
4-Amino-N-(4-trifluoromethylphenyl)benzamide |
COX | Immunology/Inflammation; Neuroscience |
Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) 是一种选择性COX-1抑制剂,IC50为 30 µM。 | |||
T1690 |
BroMhexine IMpurity B
|
Others | Others |
BroMhexine IMpurity B 试剂用于制备 Ambroxol 和 Bromhexine (B678600) 代谢物 Ambroxol EP Impurity E。 | |||
T0667 |
Flecainide Impurity D
|
Others | Others |
Flecainide Impurity D 在工业中用作中间体。 | |||
T67853 |
Rivaroxaban Impurity
Rivaroxaban-10 |
Factor Xa | Metabolism |
Rivaroxaban Impurity (Rivaroxaban-10) 是一种强效凝血因子Xa 抑制剂,IC50=66 nM。 | |||
T12962 |
Sofosbuvir impurity G
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Sofosbuvir impurity G 是 Sofosbuvir 的非对映异构体,是 Sofosbuvir 的杂质。其中 Sofosbuvir 能够抑制 HCVRNA 的复制,具有抗丙型肝炎病毒作用。 | |||
T0550 |
Domperidone EP Impurity A
5-氯-1,3-二氢-1-(4-哌啶基)-2H-苯并咪唑-2-酮 |
Others | Others |
Domperidone EP Impurity A 用作医药中间体。 | |||
T1357 |
TriMetazidine EP IMpurity-D
|
Others | Others |
TriMetazidine EP IMpurity-D 是合成 TriMetazidine 的起始原料,是合成多种化合物的中间体。 | |||
T3097 |
Mycophenolic Acid Impurity
马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide |
Others | Others |
Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) 是一种免疫抑制药物和有效的抗增殖剂,可用于代替旧的抗增殖剂 azathioprine。它通常用作三联疗法的一部分,包括钙调神经磷酸酶抑制剂(ciclosporin 或 tacrolimus)和prednisolone。它还可用于研究选择表达编码 XGPRT(黄嘌呤鸟嘌呤磷酸核糖基转移酶)的大肠杆菌基因的动物细胞。 | |||
T4196 |
Betahistine EP Impurity C
NSC19005 |
Others; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others |
Betahistine EP Impurity C (NSC19005) 是 Betahistine 的杂质。 Betahistine 是可口服的组胺 H1 受体激动剂和 H3 受体的拮抗剂,可用作血管扩张剂,用于类风湿性关节炎的研究。 | |||
T9084 |
Cetirizine Impurity B dihydrochloride
De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride,西替利嗪杂质B二盐酸盐,西替利嗪杂质04 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine Impurity B dihydrochloride (De(carboxymethoxy) Cetirizine Acetic Acid Dihydrochloride) 是 Cetirizine dihydrochloride 的杂质。Cetirizine 是一种抗组胺剂,是口服有活力的、特异性 H1受体拮抗剂。它能够抑制过敏反应期间嗜酸性粒细胞趋化,可以标记抗过敏特性。 | |||
T12961 |
Sofosbuvir impurity F
索非布韦杂质 F,Sofosbuvir 3',5'-Bis-(S)-phosphate |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) 既是 Sofosbuvir 的非对映异构体,也是 Sofosbuvir 的杂质,Sofosbuvir 是 HCV RNA 复制的抑制剂。 | |||
T1689 |
Enalapril IMpurity B
(+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine,依那普利杂质B |
Others | Others |
Enalapril IMpurity B ((+)-N-[1-(S)-Ethoxycarbonxyl-3-phenylpropyl]-L-alanine) 是 Moexipril 中间体,是 Imidapril 的主要代谢物。 | |||
T21113 |
N2-Acetylaciclovir
Aciclovir EP Impurity F |
Antibacterial | Microbiology/Virology |
N2-Acetylaciclovir (Aciclovir EP Impurity F) 是抗病毒化合物Aciclovir 的 衍生物,具有选择性T 细胞免疫毒性。 | |||
T32550 |
Lamivudine impurity A RS
Lamivudine impurity A,Lamivudine specified impurity A |
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Lamivudine impurity A RS is a bioactive chemical. | |||
T39031 |
Olmesartan impurity
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Olmesartan impurity, a compound related to Olmesartan, is an angiotensin II receptor (AT1R) antagonist utilized in the study of high blood pressure. Olmesartan (RNH-6270) is the parent compound with similar properties and functions as an AT1R antagonist. | |||
T20997 |
Amlodipine besilate impurity B
Amlodipine EP Impurity B |
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Amlodipine besilate impurity B is a biochemical. | |||
T36076 |
Ciprofibrate impurity A
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Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate is a PPARα agonist[1]. [1]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8. | |||
T40537 | Ibuprofen Impurity K | ||
Ibuprofen Impurity K is a compound that serves as an impurity in Ibuprofen. Ibuprofen itself is an anti-inflammatory inhibitor specifically designed to target COX-1 and COX-2. It exhibits inhibitory activity with IC50 values of 13 μM and 370 μM for COX-1 and COX-2, respectively. | |||
T40785 |
Gefitinib impurity 1
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Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 50 = 54 nM) and inhibits EGFR autophosphorylation induced by EGF in tumor cells. Additionally, Gefitinib induces autophagy and exhibits antitumor activity. | |||
T1364 |
7-Aminodeacetoxycephalosporanic acid
7-ADCA,Cephalexin Impurity B,Cefalexine EP IMpurity B,Deacetoxycephalosporanic Acid,头孢氨苄杂质B,7-Aminodesacetoxycephalosporanic acid |
Antibiotic | Microbiology/Virology |
7-Aminodeacetoxycephalosporanic acid (Cefalexine EP IMpurity B) 是一种头孢菌素合成中的关键中间体。 | |||
T37704 |
Olanzapine Lactam Impurity
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Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1It is a degradation product formed by exposure to thermal or oxidative stress. 1.Baertschi, S.W., Brunner, H., Bunnell, C.A., et al.Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulationsJ. Pharm. Sci.97(2)883-892(2008) | |||
T36945 |
Cetirizine Impurity C
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Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine and the carboxylated metabolite of hydroxyzine. It acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor[1][2]. | |||
T36592 |
Impurity of Calcipotriol
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Impurity of Calcipotriol 是卡泊三醇的杂质,卡泊三醇是一种合成的 VitD3 类似。 | |||
T2692 |
A40926
Dalbavancin Impurity,达巴霉素杂质 |
Antibacterial | Microbiology/Virology |
A40926 (Dalbavancin Impurity) 是Dalbavancin 的前体,是一种糖肽抗生素。它抑制革兰氏阳性细菌,对淋病奈瑟氏球菌非常有效。 | |||
T37026 |
Mesalamine impurity P
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Mesalamine impurity P is an impurity of Mesalamine . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1]. [1]. Kyle Dammann, et al.PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60. | |||
T37176 | Edoxaban impurity 6 | ||
Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe... | |||
T20995 |
Amlodipine besilate impurity D
Amlodipine Related Compound A,Amlodipine impurity A |
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Amlodipine besilate impurity D is a biochemical. | |||
T40941 |
Olmesartan lactone impurity
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Olmesartan lactone impurity is a cyclic ester impurity derived from Olmesartan, which is an angiotensin II receptor (AT1R) antagonist with potential applications in the study of high blood pressure. | |||
T37628 | Ibuprofen impurity 1 | ||
Ibuprofen impurity 1 is an Ibuprofen impurity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1]. [1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. | |||
T35430 | Afatinib impurity 11 | ||
Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively[1]. [1]. Li D, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. | |||
T40752 |
Ibuprofen Impurity F
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Ibuprofen Impurity F is a known impurity of Ibuprofen, which acts as an anti-inflammatory inhibitor that selectively targets both COX-1 and COX-2 enzymes. It exhibits inhibitory activity with IC50 values of 13 μM and 370 μM for COX-1 and COX-2, respectively. | |||
T35728 |
Hydrochlorothiazide Impurity C
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Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.[2][3][4] | |||
T37175 |
Edoxaban impurity 4
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Edoxaban impurity 4, an impurity of Edoxaban (DU-176), is a selective, potent, and orally active inhibitor of factor Xa (FXa), exhibiting Kis of 0.561 nM for free FXa and 2.98 nM for prothrombinase. As an anticoagulant agent, Edoxaban is utilized for stroke prevention[1][2]. | |||
T35876 |
Chlorthalidone Impurity G
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Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an... | |||
T2025 |
HDAC-IN-7
HBI-8000,西达本胺杂质,CS055,Chidamide impurity |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDAC-IN-7 (HBI-8000) 是 Chidamide 的一种杂质。Chidamide 是一种可口服的 HDAC 酶 I 类 HDAC1/2/3 和 IIb 类 HDAC10 抑制剂。 | |||
T36006 |
Olmesartan medoxomil impurity C
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Olmesartan medoxomil impurity C is an Olmesartan medoxomil impurity. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. [1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Phar... | |||
T29998 |
Amlodipine besilate impurity F
Amlodipine Dimethyl Ester,Amlodipine USP Related Compound F,Amlodipine EP Impurity F |
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Amlodipine besilate impurity F, also known as Amlodipine Dimethyl Ester, is a biochemical. | |||
T10957 |
Dapagliflozin impurity
|
Others | Others |
Dapagliflozin impurity is the enantiomer of Dapagliflozin, Dapagliflozin is a sodium glucose transporter 2 inhibitor. | |||
T39885 |
Captopril EP Impurity E
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Captopril EP Impurity E is an impurity of Captopril. Captopril, also known as SQ-14534, is an orally active angiotensin-converting enzyme (ACE) inhibitor that contains a thiol group. It has antihypertensive properties and competes with ACE with an inhibitor constant (IC 50 ) of 0.025 μM. | |||
T20996 |
Amlodipine besilate impurity E
Amlodipine Diethyl Ester,Amlodipine EP Impurity E,Amlodipine USP Related Compound E |
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Amlodipine besilate impurity E is a biochemical. | |||
T0614 |
4-Amino-5-Chloro-2-Methoxybenzoic Acid
甲氧氯普胺杂质C,Metoclopramide EP Impurity C |
Others | Others |
4-Amino-5-Chloro-2-Methoxybenzoic Acid (Metoclopramide EP Impurity C) 是一种Metoclopramide 代谢物。 | |||
T11997 |
MELK-IN-1
Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L |
MELK | PI3K/Akt/mTOR signaling |
MELK-IN-1 (MELK inhibitor 17)是一种母体胚胎亮氨酸拉链激酶的有效抑制剂,IC50=3 nM,Ki=0.39 nM。 | |||
T38577 | Remdesivir O-desphosphate acetonide impurity | ||
Remdesivir O-desphosphate acetonide impurity is a contaminant found in Remdesivir. Remdesivir (GS-5734) is a nucleoside analogue known for its potent antiviral properties, particularly in inhibiting SARS-CoV-2 (COVID-19) infection in vitro. | |||
T12957 |
Sofosbuvir impurity B
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Others | Others |
Sofosbuvir impurity B is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity. | |||
T12969 |
Sofosbuvir impurity N
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HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN5757 |
p-Hydroxybenzaldehyde glucoside
4-formylphenyl b-d-glucopyranoside,Gastrodin Impurity |
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p-Hydroxybenzaldehyde glucoside (4-formylphenyl b-d-glucopyranoside) 是抑制天麻素衍生物,具有镇痛活性,可以用于研究神经源性疼痛。 | |||
TN7045 |
N-phenethylbenzamide
N-(2-Phenylethyl)benzamide,Solina New Impurity 21,N-苯乙基-苯甲酰胺,4-(DICHLOROMETHYL)PYRIDINE HCL |
Others | Others |
N-phenethylbenzamide (Solina New Impurity 21) 是一种天然产物。 | |||
TN7036 |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路,诱导间充质干细胞成骨分化和随后的骨形成,可用于研究骨质疏松症。 | |||
TN7064 |
Candicine
4-Hydroxy-N-Benzeneethanaminium,N, N, N-trimethyltyramine chloride,Candicin,N-Methylhordenine,Tyramine Impurity 1,4-羟基-N,N,N-三甲基-苯乙铵,2-(4-hydroxyphenyl)ethyl-trimethylazanium |
Others | Others |
Candicine (N, N, N-trimethyltyramine chloride) 是来自 Stapelia gigantea 的天然产品。 | |||
TN6498 |
Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester)
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Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6498,CAS号为 1309929-72-3。 | |||
TN1352 |
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide
12顺-亚油酸酰胺,(9Z,12Z)-N-(3-Methoxybenzyl)octadeca-9,12-dienamide,n-3-methoxybenzyl-9z-12z-octadecadienamide,玛卡酰胺杂质10 |
Drug Metabolite | Metabolism |
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide ((9Z,12Z)-N-(3-Methoxybenzyl)octadeca-9,12-dienamide) 是一种 Macamide 杂质,可能用于代谢疾病的研究。 |