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Search Results for " hyperglycemic "

10

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78059	Glucagon (Human) Hyperglycemic-glycogenolytic factor,Glukagon	Others	Others
	Glucagon 对蛋白质和氨基酸的代谢产生显著的调节作用。它抑制了氨基酸与肝脏、肌肉以及胰腺蛋白的结合，增加氮的排出，并促进肝脏内尿素的合成。同时，Glucagon 增加了肝脏中转氨酶和尿素循环酶的浓度，提高了肝脏对氨基酸的摄取，并加强了氨基酸与肝糖原之间的结合，从而降低了血液中的氨基酸浓度。
T62091	Anti-hyperglycemic agent-1
	Anti-hyperglycemic agent 1 是一种 α- 葡萄糖苷酶 (α-Glucosidase) 的有效抑制剂 (IC50: 0.53 μM)。Anti-hyperglycemic agent 1 能够用于研究糖尿病。
T5954	Methyldopa hydrate L-甲基多巴,Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate	Dopamine Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methyldopa hydrate (MK-351 hydrate) 是一种前药，在中枢神经系统中被代谢成 α-Methylepinephrine。它是一种 α-肾上腺素能激动剂，对α2-adrenergic receptors 有选择性。
T32754	Limiglidole
	Limiglidole is an anti-hyperglycemic drug candidate.
T30166	ASP-4000 HCl ASP4000 HCl,ASP 4000 HCl,UNII-7393JFE67B
	ASP-4000 HCl is an inhibitor of dipeptidyl peptidase 4 (DPP) with anti-hyperglycemic activity.
T10362L	AR453588 hydrochloride	Others	Others
	AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
T10362	AR453588	Others	Others
	AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.
T80715	α-Amylase/α-Glucosidase-IN-6
	α-Amylase/α-Glucosidase-IN-6 (compound 5j) 是一种对α-amylase和α-glucosidase具有双重抑制作用的有效化合物，其IC50s分别为17.0 µM和40.1 µM。该化合物还表现出抗高血糖活性。
T35798	Massarigenin C
	Massarigenin C is a fungal metabolite that has been found inM. flavoroseaand has enzyme inhibitory activities.1,2Massarigenin C inhibits neuraminidasein vitro(IC50= 4.15 μM).2It is also an inhibitor of yeast α-glucosidase (IC50= 1.25 mM).1It reduces the postprandial peak in blood glucose levels in an oral sucrose tolerance test in normo- and hyperglycemic mice when administered at doses of 3.2, 10, and 31.6 mg/kg.
T62542	GPR40 agonist 5
	GPR40 agonist 5 是一种口服具有活力的 GPR40 (G 蛋白偶联受体 40) 激动剂 (EC50: 47 nM)。GPR40 agonist 5 能够减少血糖水平，改善糖耐量。GPR40 agonist 5 对 2 型糖尿病小鼠的高血糖状态表现出充足的控制作用。

化合物

Glucagon (Human)

Cat.No: T78059

Synonym: Hyperglycemic-glycogenolytic factor,Glukagon

Target: Others

Anti-hyperglycemic agent-1

Cat.No: T62091

Methyldopa hydrate

Cat.No: T5954

Synonym: L-甲基多巴,Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate

Target: Dopamine Receptor, Adrenergic Receptor

Cat.No: T32754

Cat.No: T30166

Synonym: ASP4000 HCl,ASP 4000 HCl,UNII-7393JFE67B

AR453588 hydrochloride

Cat.No: T10362L

Target: Others

Cat.No: T10362

Target: Others

α-Amylase/α-Glucosidase-IN-6

Cat.No: T80715

Cat.No: T35798

GPR40 agonist 5

Cat.No: T62542

Cat. No.	Product Name	Target	Signaling Pathways
T3672	Nomilin	MAPK	MAPK
	Nomilin 是一种柠檬苦素类化合物，从柑桔类提取物中获得，是抗肥胖症和降糖药。
T0505	Methyldopa L-(-)-α-Methyldopa,MK-351,甲基多巴	Dopamine Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-(-)-α-Methyldopa (MK-351) 是一种前药，在中枢神经系统中被代谢成 α-Methylepinephrine。它是 α-肾上腺素能激动剂，对 α2- adrenergic receptors 有选择性。
TN1513	Clitorin 碟豆宁,碟豆素	PKC; Antifection	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Clitorin 是一种山奈酚糖苷，分离自 Acalypha indica 的花和叶，表现出抗氧化活性。
TN6793	Demethylisoencecalin 6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran	Others	Others
	Demethylisoencecalin (6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran) 具有抗高血糖活性。
T3747	syringaldehyde Syringic aldehyde,丁香醛,Springaldehyde	COX	Immunology/Inflammation; Neuroscience
	syringaldehyde 是可从厚朴和木薯中分离得到的黄酮类多酚，具有抗氧化、抗高血糖和抗炎活性，可适度抑制COX-2活性，IC50为 3.5 μg/mL。
TN3532	Borapetoside E	Others	Others
	Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.
T80007	Stevisalioside A	Phosphatase	Metabolism
	Stevisalioside A (Compound 2)，一种从甜叶菊根提取的化合物，展现出抗糖尿病的口服活性。该化合物有效抑制PTP1B，IC50为526.8 μM，并能降低Stevisalioside A引起的高血糖小鼠血糖水平，改善餐后血糖峰值及口服葡萄糖和胰岛素耐量测试结果。

天然产物

Cat.No: T3672

Target: MAPK

Cat.No: T0505

Synonym: L-(-)-α-Methyldopa,MK-351,甲基多巴

Target: Dopamine Receptor, Adrenergic Receptor

Cat.No: TN1513

Synonym: 碟豆宁,碟豆素

Target: PKC, Antifection

Demethylisoencecalin

Cat.No: TN6793

Synonym: 6-Acetyl-5-hydroxy-2,2-dimethyl-2H-1-benzopyran

Target: Others

Cat.No: T3747

Synonym: Syringic aldehyde,丁香醛,Springaldehyde

Target: COX

Cat.No: TN3532

Target: Others

Stevisalioside A

Cat.No: T80007

Target: Phosphatase

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