Cat. No. | Product Name | Target | Signaling Pathways |
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T21505 |
Suberoyl bis-hydroxamic acid
SBHA,软木肟酸,Suberohydroxamic acid |
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂,ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径,可研究甲状腺髓样癌。 | |||
T1583 |
Vorinostat
MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA |
Apoptosis; Mitophagy; Virus Protease; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM),对 HDAC1/2/3/6/7/11 均有抑制活性。 Vorinostat 具有抗肿瘤活性,可以诱导细胞分化,阻滞细胞周期,诱导细胞凋亡。 | |||
T36105 |
coumarin-SAHA
coumarin-Suberoylanilide Hydroxamic Acid,coumarin-SAHA |
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Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm | |||
T14864 |
Caracemide
NSC-253272,卡醋胺 |
Others; DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Caracemide (NSC-253272) 抑制大肠杆菌的核糖核苷酸还原酶。 Caracemide 可用于抗癌研究。 | |||
T1592 |
Acetohydroxamic acid
Methylhydroxamic acid,Acetic acid,Lithostat,AHA,oxime,N-Hydroxyacetamide,乙酰氧肟酸 |
MMP; Antibacterial | Microbiology/Virology; Proteases/Proteasome |
Acetohydroxamic acid (N-Hydroxyacetamide) 是一种不可逆的细菌和植物尿素酶抑制剂,可研究慢性尿路感染。 | |||
T13996 |
1-Naphthohydroxamic acid
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HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
1-Naphthohydroxamic acid 是一种选择性 HDAC8抑制剂,IC50为 14 μM。它对 HDAC8的选择性高于 I 类 HDAC1 和 II 类 HDAC6,IC50大于100 μM,可诱导微管蛋白乙酰化。 | |||
T33614 |
n-Decanohydroxamic acid
N-Hydroxydecanamide,Decanohydroxamic acid,Caprinohydroxamic acid |
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n-Decanohydroxamic acid is a biochemical. | |||
T72148 | Phosphoglycolohydroxamic acid | ||
Phosphoglycolohydroxamic acid 是有效抑制醛缩酶(aldolase)和磷酸丙糖异构酶(triose-phosphate isomerase)的化合物,同时在抗菌和抗真菌领域的研究中具有应用潜力。 | |||
T14043 |
4-(tert-Butyl)-benzhydroxamic Acid
|
Others | Others |
4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1]. | |||
TQ0052 |
SH5-07
|
STAT | JAK/STAT signaling; Stem Cells |
SH5-07 是一种基于异羟肟酸的 Stat3 抑制剂,IC50值为 3.9 μM。 | |||
T0721 |
Piroctone olamine
Piroctone ethanolamine,羟吡酮,吡罗克酮乙醇胺盐 |
Antibiotic; Antifungal | Microbiology/Virology |
Piroctone olamine (Piroctone ethanolamine) 是一种吡啶衍生物,可用于治疗真菌感染。 | |||
T8517 |
Belinostat
PX105684,PXD101,贝利司他,PXD-101 |
HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Belinostat (PXD101) 是一种异羟肟酸型组蛋白脱乙酰酶抑制剂,具有抗肿瘤活性,在 HeLa 细胞提取物中的IC50为 27 nM。 | |||
T16729 |
Remetinostat
SHP-141 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Remetinostat (SHP-141) 是一种基于异羟肟酸的组蛋白脱乙酰酶抑制剂,可用于治疗皮肤 T 细胞淋巴瘤的研究。 | |||
T1852 |
Rac-Belinostat
NSC726630,PXD101,PX-105684 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rac-Belinostat (PX-105684) 是一种具有抗肿瘤活性的新型异羟肟酸型组蛋白脱乙酰酶 (HDAC) 抑制剂。 Belinostat 靶向 HDAC 酶,从而抑制肿瘤细胞增殖、诱导细胞凋亡、促进细胞分化和抑制血管生成。这种药物可以使耐药肿瘤细胞对其他抗肿瘤药物敏感,可能是通过一种涉及胸苷酸合酶下调的机制。 | |||
T33551 |
N(alpha)-Acetylfusarinines
Nalpha-Acetylfusarinines |
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N(alpha)-Acetylfusarinines is a group of naturally occurring hydroxamic acids produced by unidentified species of Penicillium when grown on iron-deficient media. | |||
T68085 |
Idrapril
|
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Idrapril 是一种血管紧张素转换酶(ACE)抑制剂,通过将具有重要催化作用的锌离子与羟基肟基团结合而起作用。 | |||
T74166 | Microtubule destabilizing agent-1 | ||
Microtubule destabilizing agent-1 (Compound 12b)为基于异羟肟酸的微管去稳定剂(MDA)。该化合物表现出良好的代谢稳定性、高生物利用度及有效的抗肿瘤活性。 | |||
T35765 |
SAHA-BPyne
|
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Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. SAHA-BPyne is a SAHA derivative with a benzophenone crosslinker and an alkyne tag intended to be used for profiling HDAC activities in proteomes and live cells. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azi... | |||
T71110 |
Nanatinostat TFA
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Nanatinostat, also known as Tractinostat, CHR-3996 and VRx-3996, is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor... | |||
T36110 |
L-Pyrohomoglutamic Acid
|
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L-Pyrohomoglutamic acid is an amino acid building block.1,2It has been used in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. 1.Pomplun, S., Wang, Y., Kirschner, A., et al.Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs)Angew. Chem. Int. Ed.54(1)345-348(2015) 2.Taddei, M., Cini, E., Giannotti, L., et al.Lactam based 7-amino suberoylamide hydroxamic acids as potent HDAC inhibitors... | |||
T35762 | MC1742 | ||
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin... | |||
T38381 |
CAY17c
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CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,... |