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3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16708 |
R-268712
|
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。 | |||
T60226 |
CT52923
|
PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological diseases such as atherosclerosis, glomerulonephritis, liver cirrhosis, pulmonary fibrosis, and cancer. | |||
T73375 |
CK2-IN-4
|
Casein Kinase | Metabolism; Stem Cells |
CK2-IN-4 是一种蛋白激酶 (CK2) 抑制剂 ,IC50 值为 8.6 µM。 CK2-IN-4 具有潜在的抗癌啊和抗炎活性,可用于研究病毒感染和肾小球肾炎的疾病。 | |||
T63272 |
Edralbrutinib
TG-1701 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Edralbrutinib (TG-1701) 是有效的BTK抑制剂,具有抗癌活性,可用于治疗肿瘤、免疫系统疾病、血液及淋巴系统疾病。Edralbrutinib可用于研究膜性肾小球肾炎和视神经脊髓炎。 | |||
T68182 |
3-Hydroxykynurenamine
|
||
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ... | |||
T36673 | CC 401 dihydrochloride | ||
High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication. Uehara et al (2004) c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 78 324 PMID:15316358 |Uehara et al (2005) JNK mediates hepatic ischemia reperfusion injury. J... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3869 |
Skimmin
茵芋苷,Skimmine |
Others | Others |
Skimmin (Skimmine) 是一种香豆素类物质。存在于圆锥绣球中,能够抑制免疫复合物的沉积,具有抗炎作用。 | |||
T3775 |
Armepavine
亚美罂粟碱,R-Armepavine,(-)-Armepavine |
IκB/IKK; NF-κB | NF-κB |
Armepavine (R-Armepavine) 是来自Nelumbo nucifera 的活性化合物,能够抑制 TNF-α 诱导的MAPK 和NF-κB 信号级联反应。它不仅对人外周血单核细胞具有抗炎作用,且对 T 淋巴细胞和狼疮肾炎小鼠也具有免疫抑制作用。 | |||
T78492 |
D-Mannuronic acid sodium
|
||
D-Mannuronic acid sodium,一种可从Macrocystis pyrifera中分离得到的化合物,显示出在自身免疫性脑脊髓炎(EAE)、佐剂性关节炎(AIA)、肾病综合征以及急性肾小球肾炎的研究中具有潜在应用价值。 |