16
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40781L1 |
Geranylgeranyl pyrophosphate tetrabutylammonium(1:2)
Geranylgeranyl pyrophosphate tetrabutylammonium(1:2)(6699-20-3 Free base) |
Others | Others |
Geranylgeranyl pyrophosphate tetrabutylammonium(1:2)是甲羟戊酸途径产生内源性胆固醇和中间体之一。Geranylgeranyl pyrophosphate tetrabutylammonium(1:2) 香叶基香叶基焦磷酸三铵是二萜类化合物的常见前体,例如紫杉醇,可用于癌症研究。 | |||
T36863 |
Geranylgeranyl Pyrophosphate (ammonium salt)
Geranylgeranyl Pyrophosphate (ammonium salt),GGPP |
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Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco... | |||
T25450 |
GGTI 2147
GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147 |
NF-κB; Rho | Cell Cycle/Checkpoint; NF-κB |
GGTI 2147 降低 Rac1 活性,下调 p65 的表达,改善 OGD/R 诱导的神经元凋亡。 | |||
T40781 |
Geranylgeranyl pyrophosphate
|
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Geranylgeranyl pyrophosphate, a key metabolite in protein geranylgeranylation, serves as the universal precursor for diterpenoids, such as Paclitaxel. Its role in cancer research stems from this critical function. | |||
T40781L |
Geranylgeranyl pyrophosphate tetrabutylammonium(1:1.5)
|
Others | Others |
(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl dihydrogen diphosphate,tetrabutylammonium(1:1.5) 是紫杉二烯,如紫杉醇,的常见前体。 | |||
T37693 |
N-acetyl-S-geranylgeranyl-L-Cysteine
|
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N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins. | |||
T83926 |
S-Geranylgeranyl-L-glutathione
GGG |
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S-Geranylgeranyl-L-glutathione是孤儿G蛋白偶联受体(GPCR)P2RY8的配体。该化合物在100 nM浓度下,选择性地诱导P2RY8而非鞘氨醇-1-磷酸受体2(S1P2)、GPR55、半胱氨酸白三烯受体1(CysLT1 receptor)以及CysLT2 receptor的内吞作用。在10 nM浓度下,S-Geranylgeranyl-L-glutathione抑制了表达P2RY8的WEHI-231 B细胞淋巴瘤细胞和分离的人扁桃体生发中心B细胞由趋化因子(C-X-C motif)配体12(CXCL12)诱导的迁移。 | |||
T11282 |
FGTI-2734
|
Transferase | Metabolism |
FGTI-2734 是 有效的RAS C-末端法尼基转移酶 (FT) 和香叶烯基转移酶-1 (GGT-1) 抑制剂,IC50s 分别为 250 nM 和 520 nM。 它可以阻断 KRAS 的膜定位,从而解决 KRAS 耐药性问题,并抑制突变的 KRAS 胰腺肿瘤。 | |||
T12452 |
Digeranyl bisphosphonate
DGBP |
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
Digeranyl bisphosphonate (DGBP) 是一种有效的香叶基焦磷酸香叶酯 (GGPP) 合酶抑制剂,对 Rac1 的香叶基焦磷酸化有抑制作用。Digeranyl bisphosphonate 诱导细胞发生自噬却不诱导细胞凋亡。 | |||
T11330L |
FTI-2148
|
Others | Others |
FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively). | |||
T35589 |
Geranyl pyrophosphate triammonium
|
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Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the biosynthesis of farnesyl pyrophosphate , geranylgeranyl pyrophosphate , cholesterol, terpenes, and terpenoids. | |||
T11330 |
FTI-2148 diTFA
|
Others | Others |
FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively. | |||
T11282L |
FGTI-2734 mesylate (1247018-19-4 free base)
FGTI-2734 mesylate |
Others | Others |
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors. | |||
T69205 |
GGTI-2166
|
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GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. | |||
T72989 |
hGGPPS-IN-3
|
Apoptosis | Apoptosis |
hGGPPS-IN-3(Compound 13h)是一种针对人类香叶基香叶基焦磷酸合成酶(hGGPPS)的有效抑制剂,属于C-2取代的噻吩并嘧啶基双膦酸盐(C2-ThP-BPs)衍生物。该化合物能够诱导多发性骨髓瘤(MM)细胞具有选择性地进入凋亡(apoptosis),并且在体内展现了对抗骨髓瘤的活性。 | |||
T63906 | hGGPPS-IN-2 | ||
hGGPPS-IN-2 是一种 C-2 取代的噻吩并嘧啶基双膦酸盐 (C2-ThP-BPs) 的类似物,是一种有效的人类香叶基香叶基焦磷酸合成酶 (hGGPPS) 抑制剂。hGGPPS-IN-2 能够靶向作用于多发性骨髓瘤 (MM) 细胞,诱导其选择性凋亡 (apoptosis),并在体内显示出抗骨髓瘤作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T3314 |
Perillyl alcohol
Isocarveol,Perilla alcohol,紫苏醇 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Perillyl alcohol (Isocarveol) 是一种单萜,可在不影响正常细胞的情况下诱导肿瘤细胞凋亡。 |