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Search Results for " genotoxicity "

10

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38311	(S)-3-Thienylglycine	Others	Others
	(S)-3-Thienylglycine 是一种噻吩衍生物，可用于研究与噻吩衍生物相似结构的遗传毒性。
T40382	Dibromoacetaldehyde
	Dibromoacetaldehyde, a halogenated byproduct found in drinking water, exhibits genotoxicity.
T9791	Mequindox
	Mequindox(MEQ) 是一种抗菌剂。Mequindox 作为DNA 合成的抑制剂，对小鼠具有遗传毒性和致癌性。
T63495	CYP2C1/CYP2C19-IN-2
	CYP2C1/CYP2C19-IN-2 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂，能够用于研究寨卡病毒 (ZIKV) 感染。
T63496	CYP2C9/CYP2C19-IN-1
	CYP2C9/CYP2C19-IN-1 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂，能够用于研究寨卡病毒 (ZIKV) 感染。
T79212	mTOR inhibitor-12	mTOR	PI3K/Akt/mTOR signaling
	mTORinhibitor-12（Compound 11）为选择性脑渗透性mTOR抑制剂，无遗传毒性风险，适用于中枢神经系统疾病研究。
T63025	Antitubercular agent-26
	Antitubercular agent-26 (Compound 32) 是一种口服具有活力的抗结核剂，能够作用于 M. tuberculosisH37Rv 细胞（在细胞外的 IC50: 0.50 μM，细胞内的 IC50: 0.51 μM)。Antitubercular agent-26 具有良好的代谢稳定性，及低心脏毒性风险低，没有遗传毒性。
T70782	PF-05139962
	PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in ...
T35646	4-oxo-2-Nonenal 4-oxo-2-Nonenal,4-ONE
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity and has been widely used as a marker of lipid peroxidation.[1][2][3] 4-oxo-2-Nonenal is a more recently identified product of lipid peroxidation.[4][5][6] It actively modifies histidine and lysine residues on prot...
T36001	4-hydroperoxy 2-Nonenal
	4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress. 4-HNE exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. 4-hydroperoxy 2-Nonenal is the immediate precursor of 4-HNE formed from the cleavage of ω-6 hydroperoxides. Analogous reactions are expected to occur with hydroper...

化合物

(S)-3-Thienylglycine

Cat.No: T38311

Target: Others

Dibromoacetaldehyde

Cat.No: T40382

Cat.No: T9791

CYP2C1/CYP2C19-IN-2

Cat.No: T63495

CYP2C9/CYP2C19-IN-1

Cat.No: T63496

mTOR inhibitor-12

Cat.No: T79212

Target: mTOR

Antitubercular agent-26

Cat.No: T63025

Cat.No: T70782

4-oxo-2-Nonenal

Cat.No: T35646

Synonym: 4-oxo-2-Nonenal,4-ONE

4-hydroperoxy 2-Nonenal

Cat.No: T36001

Cat. No.	Product Name	Target	Signaling Pathways
T2S2109	Skimmianine beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine	Others	Others
	Skimmianine (Chloroxylonine) 是一种呋喹啉类生物碱，主要存在于芸香科，具有抗炎、抗痉挛和抗血小板聚集活性。它对多种癌细胞系具有细胞毒性和基因毒性。
TN1162	Dibutyl phthalate 1,2-Benzenedicarboxylic acid	Antifection	Microbiology/Virology
	Dibutyl phthalate (1,2-Benzenedicarboxylic acid) 是一种增塑剂，广泛用于工业制造。Dibutyl phthalate可调节 MSH6 巴豆酰化，可诱导诱导氧化损伤和遗传毒性，可破坏果蝇和人体细胞中保守的昼夜节律。
T4822	N-Acetylglycine N-乙酰甘氨酸,Acetamidoacetic acid,Aceturic acid	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetylglycine (Aceturic acid) 是一种食物中的少量成分，无基因毒性和急性毒性，能够用于模拟肽的生物研究。
T3860	Isoliquiritin apioside	MMP; p38 MAPK; NF-κB	MAPK; NF-κB; Proteases/Proteasome
	Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成，显著降低 PMA 诱导的MMP9活性增加，并抑制 PMA 诱导的MAPK 和NF-κB 活化。
TN1962	Myricetin 3-O-galactoside Myricetin 3-O-beta-D-galactopyranoside	NOS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) 可抑制黄嘌呤氧化酶 (xanthine oxidase; XO) 活性，脂质过氧化并清除自由基。杨梅素3- o -半乳糖苷具有很多作用包括细胞毒性、抗氧化、抗基因毒性、抗感染性、抗炎作用和抗氧化活性，其主要作用是抑制诱导型一氧化氮合酶(iNOS)的合成。Myricetin 3-O-galactoside 抑制脂质过氧化的 IC50 为 160 μg/mL。
T3S2259	Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。
T16160	Musk tibetene Musk tibetine	Others	Others
	Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity.
TN4841	Ptaquiloside
	Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium.
TN4084	Fumitremorgin B	Antifection	Microbiology/Virology
	Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic

天然产物

Cat.No: T2S2109

Synonym: beta-Fagarine,Skimmianin,茵芋碱,Chloroxylonine,Skimmiamine

Target: Others

Dibutyl phthalate

Cat.No: TN1162

Synonym: 1,2-Benzenedicarboxylic acid

Target: Antifection

N-Acetylglycine

Cat.No: T4822

Synonym: N-乙酰甘氨酸,Acetamidoacetic acid,Aceturic acid

Target: Others, Endogenous Metabolite

Isoliquiritin apioside

Cat.No: T3860

Target: MMP, p38 MAPK, NF-κB

Myricetin 3-O-galactoside

Cat.No: TN1962

Synonym: Myricetin 3-O-beta-D-galactopyranoside

Target: NOS, Xanthine Oxidase

Cat.No: T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

Target: GABA Receptor

Cat.No: T16160

Synonym: Musk tibetine

Target: Others

Cat.No: TN4841

Fumitremorgin B

Cat.No: TN4084

Target: Antifection

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