Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7318 |
Elimusertib
BAY-1895344 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Elimusertib (BAY-1895344) 是一种可口服的选择性ATR 抑制剂,IC50值为 7 nM。它具有抗肿瘤活性,可研究实体瘤和淋巴瘤。 | |||
T72024 |
ZIM
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ZIM,一种从4-Aminoantipyrine衍生的降冰片烯,有效诱导DNA损伤,造成基因组及染色体损害,进而引发细胞死亡和激活吞噬。其化疗潜力适用于癌症研究。 | |||
T3710 |
XMD16-5
|
Tyrosinase; PPAR | DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome |
XMD16-5 是TNK2抑制剂,对D163E 和R806Q 突变体的IC50值分别为16和77nM。 | |||
T3353 |
Niraparib hydrochloride
尼拉帕利盐酸盐,MK-4827 hydrochloride,MK-4827 (hydrochloride) |
Apoptosis; Others; PARP | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
Niraparib hydrochloride (MK-4827 hydrochloride) 是一种具有口服活性的PARP1和PARP2抑制剂,IC50值分别为 3.8 nM 和 2.1 nM。它抑制 DNA 损伤修复,诱导凋亡并具有抗肿瘤活性。 | |||
T35363 |
HM-cytosine
5hmC,5-Hydroxymethylcytosine,5-羟甲基胞嘧啶 |
Others | Others |
HM-cytosine (5hmC) (5hmC) 是哺乳动物基因组 DNA 中天然存在的成分,被认为是 DNA 的第六个碱基。HM-cytosine 是活性 DNA 去甲基化的中间代谢物。HM-cytosine 是已知会影响哺乳动物全局基因表达的表观遗传标记。 | |||
T9497 |
Niraparib tosylate monohyrate
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Niraparib tosylate monohyrate 也称为 MK-4827,是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂,具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性,增强 DNA 链断裂的积累,促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。 | |||
T11409 |
GLP-26
|
HBV | Microbiology/Virology |
GLP-26 是一种HBV 衣壳组装调节剂,抑制 Hep AD38 系统中的 HBV DNA 复制,IC50值为3 nM。 在 1 μM 时,使 cccDNA 降低> 90%。它破坏前基因组 RNA 的衣壳化,导致核衣壳解体,并减少 cccDNA 库。 | |||
T17031 | TEI-9647 | Others | Others |
TEI-9647 is a 1α,25-dihydroxy vitamin D3-26,23-lactone (1α,25-lactone) analog and is an effective VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist. | |||
T70115 |
Pamiparib hydrate
|
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Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo... | |||
T36593 |
TEI-9648
|
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TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons... | |||
T28293 |
Pamiparib maleate
BGB290,BGB 290,BGB-29 maleat 0 |
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Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, pro | |||
T73500 | AB-506 | ||
AB-506 是一种具有口服活性的,靶向病毒核心蛋白 HBV 复制的抑制剂。AB-506 可以与 HBV 核心蛋白结合,加速衣壳组装并抑制 HBV pgRNA 包壳。AB-506 可用于慢性乙型肝炎 (CHB)研究。 | |||
T63741 | SGK1-IN-3 | ||
SGK1-IN-3 是有效的、口服具有活力的 SGK1 抑制剂。其中丝氨酸/苏氨酸激酶 SGK1 是 β-连环蛋白途径的激活剂,也是强大的软骨降解刺激剂,在患病的骨关节炎软骨中被发现在基因组控制下被上调。SGK1-IN-3 对骨关节炎表现出研究潜力。 | |||
T35567 |
BIX01294 (hydrochloride hydrate)
|
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The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other ... | |||
T63632 | Anti-MRSA agent 3 | ||
Anti-MRSA agent 3 能够明显的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) 的活性 (MIC: 0.098 μg/ml),并且对正常细胞毒性较低。Anti-MRSA agent 3 对细菌基因组 DNA 具有较高的结合亲和力,对细菌细胞壁和细胞膜具有较强的破坏能力。 | |||
T62383 | Anti-MRSA agent 2 | ||
Anti-MRSA agent 2 (compound 14) 能够较好的抑制耐甲氧西林金黄色葡萄球菌 (MRSA) (MIC: 0.098 μg/ml),对正常细胞的毒性相对较低。Anti-MRSA agent 2 能够较强的破坏细菌膜,并具有较好的与细菌基因组DNA 结合的能力。 | |||
T82842 |
BODIPY FL EDA free base
|
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ODIPY FL EDA free base为绿色荧光胺类探针,能通过R-NH2与醛或酮反应形成可逆的席夫碱产物。使用如硼氢化钠或氰硼氢化钠等还原剂,ODIPY FL EDA free base可转化成稳定的胺衍生物,适用于检测修饰或未修饰脱氧核苷酸,以及评估DNA损伤和基因组DNA甲基化情况。 | |||
T38309 |
LL-37 amide (trifluoroacetate salt)
|
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LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ... |