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24
Cat. No. | Product Name | Target | Signaling Pathways |
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T37985 |
D-Fructose-6-phosphate (sodium salt hydrate)
D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base) |
||
D-Fructose-6-phosphate (sodium salt hydrate) 是由磷酸葡萄糖异构酶将 6-磷酸葡萄糖异构化产生的糖酵解途径的糖中间体,可用于研究癌症。 | |||
T31878 |
Fructose-arginine
Arginyl fructose,Fructose arginine,Arginyl-fructose,J1.147.777A |
||
Fructose-arginine is a maillard reaction product. | |||
T22081 |
FBPase-1 inhibitor-1
Fructose 1,6-bisphosphatase-1 Inhibitor |
Others | Others |
FBPase-1 inhibitor-1 (Fructose 1,6-bisphosphatase-1 Inhibitor) 是一种fructose-1,6-bisphosphatase (FBPase-1)的变构抑制剂。 | |||
T35442 |
1-Amino-1-deoxy-D-fructose (hydrochloride)
|
||
1-Amino-1-deoxy-D-fructose is an amino monosaccharide.1It induces site-specific DNA damage at pyrimidine residues in cell-free assays. 1-Amino-1-deoxy-D-fructose moieties have been found as a component of fructosamines, glycated serum proteins that are elevated in patients with conditions such as diabetes.2,3 | |||
T64581 | β-D-Fructose | ||
β-D-Fructose 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64581,CAS号为 53188-23-1。 | |||
T73785 | D-Fructose-6-phosphate | ||
D-Fructose 6-phosphate 是存在于唾液中的内源代谢物,可用于研究路易体痴呆。 | |||
T73732 | D-Fructose 1-phosphate disodium | ||
D-Fructose 1-phosphate disodium salt 是果糖的衍生物。它是葡萄糖代谢的重要中间体。 | |||
T65105 | D-Fructose-1,6-diphosphate trisodium salt octahydrate | ||
D-Fructose-1,6-diphosphate trisodium salt octahydrate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T65105。 | |||
T16009L |
Managlinat dialanetil
MB06322,MB 6322,CS-917 |
Phosphatase | Metabolism |
Managlinat dialanetil (MB06322) 是一种可口服且具有有效性的 fructose 1,6-bisphosphatase (FBPase) 抑制剂,具有降糖活性,可用于研究 2 型糖尿病。 | |||
T77657 |
MSNBA
|
transporter | Metabolism |
MSNBA 是一种通过 GLUT5 转运的选择性且有效的果糖转运抑制剂,也可作为 GLUT5 转运蛋白的探针。MSNBA 对 MCF7 细胞中 GLUT5 果糖摄取有抑制作用,KI 为 3.2±0.4 μM。 | |||
T3260 |
(E)-3PO
3PO |
Glucokinase | Metabolism |
(E)-3PO 是一种 PFKFB3(6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase)抑制剂。 | |||
T60222 |
3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide
|
Others | Others |
3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide 是果糖1,6-二磷酸醛缩酶的有效抑制剂。 | |||
T11955 |
MB-07729
MB07729,MB 07729 |
Phosphatase | Metabolism |
MB-07729 是一种强效的 1,6-果糖二磷酸(FBP)酶非竞争性抑制剂,对大鼠、猴子和人的 IC50 值分别为 189、121 和 31 nM,可用来研究糖尿病。 | |||
T67874 |
PFKFB3-IN-2
|
Glucokinase | Metabolism |
PFKFB3-IN-2是一种6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3 (PFKFB3)抑制剂。在体内,对PFKFB3进行反义治疗可降低肿瘤生长速度。 | |||
T16020 | MB05032 | Others | Others |
MB05032 targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase), which is a special and efficacious inhibitor of GNG. | |||
T16017 |
MB-07803
|
Others | Others |
MB07803 is an orally available prodrug of an effective, noncompetitive inhibitor of fructose 1,6-bisphosphatase (FBPase) (EC50: 140 nM and t1/2 of 7.6±2.9 h). | |||
TP2383 |
Glipentide
Staticum,UR661,UR-661,UR 661,Glisentide |
||
Glieptide, a second-generation sulfonylurea, promotes the accumulation of fructose 2, 6-diphosphate in liver cells. | |||
T16009 |
(Rac)-Managlinat dialanetil
CS-917,(Rac)-MB06322,MB06322,(Rac)-CS-917 |
Others; DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
(Rac)-Managlinat dialanetil ((Rac)-MB06322) 是 Managlinat dialanetil 的外消旋体,Managlinat dialanetil 是一种可口服且具有有效性的 fructose 1,6-bisphosphatase (FBPase) 抑制剂,可用于研究 2 型糖尿病。 | |||
T37521 |
DL-Glyceraldehyde 3-phosphate
3-Phosphoglyceraldehyde,DL-甘油醛3-磷酸 |
||
DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+. | |||
T81982 | KHK-IN-4 | ||
KHK-IN-4(compound 14)是一种针对酮己糖激酶(KHK)的高效抑制剂,适用于果糖代谢疾病的研究。 | |||
T37613 |
Ibuprofen Carboxylic Acid
|
||
Ibuprofen carboxylic acid is a major metabolite of ibuprofen . It prevents fructose-, cyanate-, and prednisolone-induced inactivation of catalase and fructose- and cyanate-induced inactivation of fumarase when used at a concentration of 2 mM and penetrates into the lens of isolated bovine eyes. Ibuprofen carboxylic acid has been found in bank filtrate and surface water, as well as influent and effluent wastewater, and is considered a micropollutant. | |||
T20256 |
Sorbitol, L-
L-Glucitol |
||
Sorbitol, L- is a sugar alcohol. It can be obtained by the reduction of glucose, which changes the aldehyde group to a hydroxyl group. It is converted to fructose by sorbitol-6-phosphate 2-dehydrogenase. Sorbitol is an isomer of mannitol, another sugar al | |||
T37783 |
2,5-Anhydro-D-mannitol
|
||
2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism. | |||
T26935 |
C108297
C-108297,C 108297 |
||
C108297 is a glucocorticoid receptor modulator. C108297 prevents both diet-induced obesity and inflammation. C108297 decreased food and fructose intake and increased lipolysis in white adipose tissue (WAT) and free fatty acid levels in plasma, resulting i | |||
T76166 |
Invertase
|
||
Invertase 是存在于植物和微生物中的一种主要酶,常用于生物化学研究。Invertase 催化双糖蔗糖水解成葡萄糖和果糖。 | |||
T76097 | Aldolase | ||
Aldolase 是一种糖酵解酶,也是 vATP 酶复合物的组成部分。Aldolase 可使 1,6-二磷酸果糖分解成二羟基丙酮和 3-磷酸甘油醛。 | |||
T37989 |
D-Sedoheptulose-7-phosphate (barium salt)
|
||
D-Sedoheptulose-7-phosphate is an intermediate in the pentose phosphate pathway. [1] [2] In this pathway, transaldolase catalyzes the transfer of a three carbon dihydroxyacetone moiety from D-sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to generate D-fructose-6-phosphate . D-Sedoheptulose-7-phosphate is also an intermediate in carbon fixation in photosynthetic organisms, as well as in the biosynthesis of lipopolysaccharide, amino acids, secondary metabolites, and antibiotics. [3] | |||
T60312 | FBPase-IN-1 | ||
FBPase-IN-1 is a powerful inhibitor of Fructose-1,6-bisphosphatase (FBPase), a key enzyme involved in Type 2 diabetes (T2D) research. It exhibits an impressive IC50 value of 0.22 μM. Aside from its potency, FBPase-IN-1 also demonstrates the ability to effectively lower blood glucose levels and improve glucose tolerance. Its mechanism of action involves covalently modifying the C128 site, thereby influencing the N125-S124-S123 allosteric pathway of FBPase, ultimately impacting its catalytic activ... | |||
T60294 | FBPase-IN-2 | ||
FBPase-IN-2 (HS36) 是一种有效的果糖-1,6-二磷酸酶 (FBPase) 共价抑制剂,IC50值为 0.15 μM。FBPase-IN-2 可减少肝细胞内葡萄糖的产生,可用于二型糖尿病的研究。 | |||
T76152 | Glucose 6-phosphate isomerase | ||
Glucose 6-phosphate isomeras (GPI) 葡萄糖 6-磷酸异构酶,即磷酸葡萄糖异构酶/磷酸葡萄糖异构酶 (PGI) 或磷酸己糖异构酶 (PHI),常用于生化研究。Glucose 6-phosphate isomeras 是一种高度保守的糖酵解酶和二聚酶。Glucose 6-phosphate isomeras 催化葡萄糖-6-磷酸异构成果糖-6-磷酸。 | |||
T60684 |
FBA-IN-1
|
||
FBA-IN-1 (compound 2a11) 是首创的,对白色念珠菌的 1,6-二磷酸果糖醛缩酶 (CaFBA) 的共价变构抑制剂。此外,FBA-IN-1 以 MIC80为 1 μg/mL,抑制唑类耐药菌株 103 的生长。 | |||
T40565 | 5MPN | ||
5MPN is a novel compound that functions as a highly potent and selective inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4). This compound demonstrates oral activity and serves as a first-in-class inhibitor. Through competitive inhibition of the F6P binding site, 5MPN effectively hinders the functionality of PFKFB4, with a Ki value of 8.6 μM. Importantly, it exhibits no inhibitory effects on PFK-1 or PFKFB3. By specifically targeting the sugar metabolism of tumors, 5MPN... | |||
T79928 |
Phosphomannose isomerase
|
||
Phosphomannose isomerase 是 GDP-Man 生物合成途径中关键的首要酶,负责催化 Fru6P 与 Man6P 之间的互转。该酶对于细胞壁合成及蛋白质糖基化过程至关重要。同时,作为一种潜在的抗真菌靶点,Phosphomannose isomerase 可以有效抑制 A. flavus。 | |||
T37119 |
1,2,3-Trioctanoyl-rac-glycerol-13C3
1,2,3-Trioctanoyl-rac-glycerol-13C3 |
||
1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomo... | |||
T76103 | Sucrose phosphorylase | ||
Sucrose phosphorylase 是一种bacterium转葡萄糖苷酶,专门催化蔗糖与磷酸盐反应形成 α-D-葡萄糖-1-磷酸和 D-果糖。此外,该酶通过glucosylation作用可以水解产生 α-D-葡萄糖或将glucosyl group转移至目标hydroxyl group,进而合成新的 α-D-葡萄糖苷。它对底物与产物的hydrolase活性表现出较弱的反应性。 | |||
T35416 |
α-D-Glucose-1-phosphate (sodium salt hydrate)
|
||
α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-... | |||
T35683 |
2-deoxy-D-Glucose-13C6
2-deoxy-D-Glucose-13C6 |
||
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B oste... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2954 |
Fructose
Fructopyranose,果糖 |
Others | Others |
Fructose (Fructopyranose) 是一种酮类单糖,在许多植物中发现。它通常与葡萄糖结合形成二糖蔗糖。 | |||
T4823 |
D-Fructose
D-fructofuranose,Fructose,levulose,D-(-)-果糖,D-arabino-hexulose,Fruit sugar |
Others | Others |
D-Fructose (D-arabino-hexulose) 是一种天然单糖,存在于许多植物中。 | |||
T4941 |
D-Fructose-6-phosphate disodium salt
D-FRUCTOSE 6-PHOSPHATE DISODIUM SALT,D-果糖-6-磷酸二钠 |
Others; Endogenous Metabolite | Metabolism; Others |
D-Fructose-6-phosphate disodium salt (D-FRUCTOSE 6-PHOSPHATE DISODIUM SALT) 是内源性代谢产物的一种。 | |||
T35618 |
D-Fructose-13C6
D-果糖 13C6 |
Others | Others |
D-Fructose-13C6 可用作通过 GC-或 LC-MS 定量 D-果糖的内标。 | |||
T37984 |
D-Fructose-1,6-bisphosphate sodium salt hydrate
|
Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T3228 |
Fosfructose
D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan |
Others; Endogenous Metabolite | Metabolism; Others |
D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐,Fosfructose 通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血,镰状细胞性贫血和哮喘的研究。 | |||
T4875 |
Palatinose hydrate
6-O-α-D-Glucopyranosyl-D-fructose, Isoma,帕拉金糖水合物 |
Others; Endogenous Metabolite | Metabolism; Others |
Palatinose hydrate (6-O-α-D-Glucopyranosyl-D-fructose, Isoma) 是内源性代谢产物的一种。 | |||
T0799 |
Lactulose
Duphalac,4-O-β-D-Galactopyranosyl-D-fructose,D-Lactulose,Lactulosum,乳果糖 |
Others | Others |
Lactulose (Lactulosum) 是一种不易吸收的糖,一般给药 8 到 12 小时后开始发挥药效,但可能需要两天时间改善便秘。它可用于便秘和肝性脑病的研究。 | |||
T8074 |
Esafosfan trisodium
Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium |
Others; Endogenous Metabolite | Metabolism; Others |
Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐,用于镰状细胞性贫血,心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷。 | |||
T4733 |
Sucrose
D(+)-Sucrose,D-(+)-Saccharose,蔗糖 |
Others; Endogenous Metabolite | Metabolism; Others |
Sucrose (D-(+)-Saccharose) 是一种二糖,由果糖和葡萄糖组成。Sucrose 能够应用于一些动物模型,包括代谢性疾病、偏食、肥胖、糖尿病等。 | |||
T10185 |
6-Phosphogluconic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
6-Phosphogluconic acid 是竞争性的磷酸葡萄糖异构酶抑制剂,对6-磷酸果糖和6-磷酸葡萄糖和的 Ki 分别为 42 μM 和 48 μM。它属于人内源性代谢物。 | |||
T4S1578 |
Nystose
1,1-Kestotetraose,耐斯糖,Fungitetraose,蔗果四糖 |
Others | Others |
Nystose (1,1-Kestotetraose) 是四糖,由两个果糖分子通过 β (1→2) 键与蔗糖的果糖基部分连接而成。 | |||
T6544 |
Inulin
菊糖 |
Others | Others |
Inulin 是一种自菊科和百合科植物的贮藏多糖,是非消化性碳水化合物果聚糖。它通常用作益生元,糖替代品,脂肪替代品,质地改良剂,在胃中起有益作用。 | |||
T8144 |
Raffinose
Melitose,Melitriose,棉子糖 |
Others; Endogenous Metabolite | Metabolism; Others |
Raffinose (Melitriose) 是不能够消化的短链寡糖,是由半乳糖,葡萄糖和果糖组成的三糖,能够在许多植物中找到。它能够被 α-半乳糖苷酶 (α-GAL) 水解为 D-半乳糖和蔗糖。 | |||
T2713 |
Stachyose tetrahydrate
Stachyose,D-Stachyose tetrahydrate,水苏糖 |
Apoptosis; Others | Apoptosis; Others |
Stachyose tetrahydrate (D-Stachyose tetrahydrate) 是一种功能性低聚糖,可在肠道内产生有益物质或通过促进益生菌的增殖,间接防止结肠癌细胞生长,可作为益生元。 | |||
T3S0309 |
D(+)-Raffinose pentahydrate
D-Raffinose pentahydrate,Raffinose,D(+)-五水棉子糖,五水棉子糖 |
Others; Endogenous Metabolite | Metabolism; Others |
D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate) 是果糖,半乳糖和葡萄糖组成的三糖,天然存在于各种蔬菜和谷物中。D(+)-Raffinose pentahydrate 是一种功能性低聚糖。 | |||
TN6745 |
PALATINOSE
TNP-470,帕拉金糖水合物,Isomaltulose |
Others | Others |
PALATINOSE (TNP-470) 是一种天然存在的二糖,由α-1,6-连接的葡萄糖和果糖组成。PALATINOSE 对肝脏代谢功能具有有益的影响,因此可能是蔗糖甜味剂的良好替代品。 | |||
TN2376 |
Fructo-oligosaccharide DP8/GF7
蔗果八糖,Fructo-oligosaccharide DP8 / GF7 |
Others | Others |
Fructo-oligosaccharide DP8/GF7 (Fructo-oligosaccharide DP8 / GF7) 是一种聚果糖,聚合度(DP=8)。Fructo-oligosaccharides 由 7 个果糖单元通过 (2→1)-β-糖苷键连接,并在非还原性末端具有 1 个 D-葡萄糖单元。 | |||
T2133 |
Adenosine monophosphate
5'-Adenylic acid,5'-腺嘌呤核苷酸,AMP,Adenosine 5'-monophosphate |
Endogenous Metabolite; AMPK | Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling |
Adenosine monophosphate (AMP) 是一种嘌呤核糖核苷5'-单磷酸腺苷,是信号转导和调节能量稳态的关键细胞代谢物。它具有EC 3.1.3.11(果糖-二磷酸酶)抑制剂、EC 3.1.3.1(碱性磷酸酶)抑制剂和腺苷A1受体激动剂的作用。 | |||
T19329 |
Fructo-oligosaccharide DP12/GF11
蔗果十二糖 |
Others | Others |
Fructo-oligosaccharide DP12/GF11 is a member of fructooligosaccharides (FOS) characterized by a degree of polymerization (DP) of 12. FOS compounds consist of 11 fructose units connected by (2→1)-β-glycosidic bonds, with a lone D-glucosyl unit located at the non-reducing end. | |||
T78485 |
D-Glucosamine 6-phosphate
Glucosamine-6-phosphate |
Endogenous Metabolite | Metabolism |
D-Glucosamine 6-phosphate为内源性代谢分子,谷氨酰胺果糖-6-磷酸氨基转移酶(GFAT)介导合成。该化合物常用于糖尿病研究领域。 | |||
TN2358 |
Fructo-oligosaccharide DP10/GF9
蔗果十糖,Fructo-oligosaccharide DP10/GF9 |
Others | Others |
Fructo-oligosaccharide DP10/GF9 is a compound classified as a fructooligosaccharide (FOS) with a degree of polymerization (DP) of 10. FOS consists of a chain of 9 fructose units connected by (2→1)-β-glycosidic bonds, with a lone D-glucosyl unit located at the non-reducing end. | |||
T19328 |
Fructo-oligosaccharide DP11/GF10
|
Others | Others |
Fructo-oligosaccharide DP11/GF10 is a fructooligosaccharide (FOS) compound with a degree of polymerization (DP) equal to 11. FOS consists of 10 fructose units connected by (2→1)-β-glycosidic bonds, with a single D-glucosyl unit present at the non-reducing end. | |||
T35415 | α-D-Glucose-1,6-bisphosphate (potassium salt hydrate) | ||
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol... |