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21

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。
T20158	Phenformin Debeone,N-Phenethylbiguanide,Insoral,BRN 1977317,Azucaps	Apoptosis	Apoptosis
	Phenformin (BRN 1977317) 是一种双胍化合物，具有抗癌和抗血糖活性，抑制皮肤肿瘤生长并促进角质形成细胞分化，促进细胞凋亡。
T20029	Buformin hydrochloride NSC528218,NSC-528218,盐酸丁双胍,NSC 528218	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂，是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收，增加胰岛素敏感性和葡萄糖对细胞的吸收，并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性，可用于各种癌症研究。
T1453	Phenformin hydrochloride Phenformin HCl,Phenethylbiguanide hydrochloride,盐酸苯乙福明	Potassium Channel; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; PI3K/Akt/mTOR signaling
	Phenformin hydrochloride (Phenformin HCl) 是一种具有抗高血糖活性的双胍类抗糖尿病药物，能够使 AMPK 活化。
T73712	Metformin-d6 hydrochloride 1,1-Dimethylbiguanide-d6 hydrochloride	AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) 是 Metformin 的一种氘代化物，可用于研究 Metformin 在体内的代谢，常作为Metformin的内标。
T8526	Metformin 甲福明,二甲双胍,1,1-Dimethylbiguanide	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin (1,1-Dimethylbiguanide) 是一种 AMPK 激活剂，具有血脑屏障渗透性。Metformin 可通过提高胰岛素敏感性和减少肠道对葡萄糖的吸收来改善血糖控制，常用于 2 型糖尿病的研究。
T0740	Metformin hydrochloride Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 是一种抗糖尿病药物，抑制结肠、前列腺等多种 Y 细胞的增殖，具有作为抗 Y 药物的潜在功能。它可以透过血脑屏障，诱导自噬。
T32177	Ioforminol GE-145,GE145,AN 113111,AN113111,AN-113111,GE 145
	Ioforminol, also known as GE-145 and AN-113111, is a new low-osmolar dimeric radiographic contrast agent. GE-145 exhibits similar preclinical properties to other dimeric radiographic contrast media. In addition, the low osmolality enables an iso-osmolar f
T32590	Lauformine
	Lauformine is a isoquinoline alkaloid.
T34878	Tiformin hydrochloride
	Tiformin hydrochloride is a biochemical.
T125793	Malformin-B4
	Malformin-B4 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125793，CAS号为 149596-55-4。
T83122	Amyloid-Forming peptide GNNQQNY
	Amyloid-Forming peptide GNNQQNY是由酵母蛋白Sup35的N-末端朊病毒决定结构域中得来的七肽段，具有生物活性，并能形成淀粉样纤维。它的详细原子低聚结构之研究，使其成为揭示早期聚集阶段的理想模型。GNNQQNY二聚体以三种稳定构形存在：寄存器内并排、寄存器外并排和反向并排。对准的平行二聚体其β-pleated sheet结构中肽链间氢键较少，强调了疏水作用的重要性，相较于反向并排结构有更高的构象熵。
T69405	Metformin embonate
	Metformin embonate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T71222	Metformin glycinate
	Metformin glycinate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T70806	Metformin icosapent
	Metformin icosapent is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T32758	Linagliptin mixture with metformin Jentadueto Xr,Linagliptin / metformin,Jentadueto
	Linagliptin mixture with metformin is used for the treatment of type 2 diabetes.
T32518	Labriformine Labriformin
	Labriformine is a nitrogen-containing cardenolide of low polarity, predominated in the latices.
T23837	Buformin 丁双胍,W37,W 37,H 224,W-37
	Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class. It also inhibits the synthesis of glucose by the liver. Buformin delays absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake
T69049	Metformin orotate
	Metformin orotate is an AMP-activated protein kinase (AMPK) activator that improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose.
T125260	19-Hydroxypseudovincadifformine
	19-Hydroxypseudovincadifformine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125260。
T30319	Benfosformin Benfosformine,JAV-52,JAV852,JAV 852,Benfosformina
	Benfosformin is a bioactive chemical.

化合物

Cat.No: T23372

Target: Others

Cat.No: T20158

Synonym: Debeone,N-Phenethylbiguanide,Insoral,BRN 1977317,Azucaps

Target: Apoptosis

Buformin hydrochloride

Cat.No: T20029

Synonym: NSC528218,NSC-528218,盐酸丁双胍,NSC 528218

Target: AMPK

Phenformin hydrochloride

Cat.No: T1453

Synonym: Phenformin HCl,Phenethylbiguanide hydrochloride,盐酸苯乙福明

Target: Potassium Channel, AMPK, Autophagy

Metformin-d6 hydrochloride

Cat.No: T73712

Synonym: 1,1-Dimethylbiguanide-d6 hydrochloride

Target: AMPK, Autophagy

Cat.No: T8526

Synonym: 甲福明,二甲双胍,1,1-Dimethylbiguanide

Target: Mitophagy, AMPK, Autophagy

Metformin hydrochloride

Cat.No: T0740

Synonym: Metformin HCl,盐酸二甲双胍,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride

Target: Mitophagy, AMPK, Autophagy

Cat.No: T32177

Synonym: GE-145,GE145,AN 113111,AN113111,AN-113111,GE 145

Cat.No: T32590

Tiformin hydrochloride

Cat.No: T34878

Cat.No: T125793

Amyloid-Forming peptide GNNQQNY

Cat.No: T83122

Metformin embonate

Cat.No: T69405

Metformin glycinate

Cat.No: T71222

Metformin icosapent

Cat.No: T70806

Linagliptin mixture with metformin

Cat.No: T32758

Synonym: Jentadueto Xr,Linagliptin / metformin,Jentadueto

Cat.No: T32518

Synonym: Labriformin

Cat.No: T23837

Synonym: 丁双胍,W37,W 37,H 224,W-37

Metformin orotate

Cat.No: T69049

19-Hydroxypseudovincadifformine

Cat.No: T125260

Cat.No: T30319

Synonym: Benfosformine,JAV-52,JAV852,JAV 852,Benfosformina

Cat. No.	Product Name	Target	Signaling Pathways
T13777	Moniliformin sodium salt	Others	Others
	Moniliformin sodium salt is water-soluble mycotoxin isolate from Fusarium moniliforme.
T36489	Malformin A
	Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhibits replication of tobacco mosaic virus (TMV) in local lesion and leaf-disc assays (IC50s = 19.7 and 45.4 μg/ml, respectively). It is cytotoxic to NCI-H460, MIA PaCa-2, MCF-7, SF-268, and WI-38 cancer cells (IC50s = 70, 50, 100, 70, and 100 nM, respectively), inhibits proliferati...
T75512	Bleformin A
	Bleformin A 是一种有效的BChE 抑制剂，其IC50值为 5.2 μM。Bleformin A 是可以从Bletilla striata 中分离得到的天然产物。Bleformin A 可用于研究阿尔茨海默病 (AD)。
T75631	Ganorbiformin B
	Ganorbiformin B是一种具有与灵芝酸相同羊毛甾烷骨架的羊毛甾烷三萜类化合物。其C-3差向异构体灵芝酸T对结核分枝杆菌H37Ra显示出强抗分枝杆菌活性。
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ...

天然产物

Moniliformin sodium salt

Cat.No: T13777

Target: Others

Cat.No: T36489

Cat.No: T75512

Ganorbiformin B

Cat.No: T75631

Cat.No: T36961

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