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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23550	YM-750 YM 750	Acyltransferase	Metabolism
	YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。
T13171	TMN355 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺	Others	Others
	TMN355 是一种化学亲环素 A 抑制剂，能够抑制泡沫细胞形成和细胞因子分泌，可用于动脉粥样硬化的研究。
T73906	Myristoyl glutamic acid sodium
	Myristoyl glutamic acid sodium，即化妆品/面霜中常用的肉豆蔻酰谷氨酸成分。作为氨基酸类表面活性剂，其清洁能力温和且具备发泡性和轻度抑菌作用。
T35985	CAY10487
	The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits....
T70356	F-1394
	F-1394 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts directly on the arterial wall. F-1394 significantly reduced neointimal thickening and the extent of macrophages in lesions without affecting serum cholesterol levels. In vitro, F-1394 attenuated foam cell formation in mouse peritoneal macrophages.

化合物

YM-750

Cat.No: T23550

Synonym: YM 750

Target: Acyltransferase

TMN355

Cat.No: T13171

Synonym: 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺

Target: Others

Myristoyl glutamic acid sodium

Cat. No.	Product Name	Target	Signaling Pathways
T3244	2-Deoxy-2-sulfoamino-D-glucose sodium 氨基葡萄糖硫酸钠盐,N-Sulfo-D-glucosamine sodium salt,N-Sulfo-glucosamine sodium salt,GlcN-2S,2-Deoxy-2-sulfamino-D-glucopyranose	Others; Endogenous Metabolite	Metabolism; Others
	2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) 是内源性代谢产物的一种。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN5097	Tanshindiol C	LDL; Histone Methyltransferase	Chromatin/Epigenetic; Metabolism
	Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.It possesses a unique anti-cancer activity whose mechani
T27977	Manzamine A Keramamine A
	Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram negative and gram positive bacteria, an
TN4600	Myrianthic acid	PAFR; AChR	GPCR/G Protein; Neuroscience
	Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoproteins at a 50 uM concentration. Myrianthic acid is equivalently inhibitive as acetylsalicylic acid (IC50: 57.0 microM) on epinephrine induced platelet aggregation.