Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMN355 是一种化学亲环素 A 抑制剂,能够抑制泡沫细胞形成和细胞因子分泌,可用于动脉粥样硬化的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 413 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,480 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,320 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 892 | 现货 |
产品描述 | TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. |
体外活性 | Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p 0.0001).?Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced.?TMN 355 (0.5-10 μM;?3-9 hours) results in 75.9% reduction of cyclophilin A protein expression.?And cyclophilin A after 6 h of activation inhibited by TMN 355(1 μM). |
别名 | 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺 |
分子量 | 380.8 |
分子式 | C21H14ClFN2O2 |
CAS No. | 1186372-20-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (82.06 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6261 mL | 13.1303 mL | 26.2605 mL | 65.6513 mL |
5 mM | 0.5252 mL | 2.6261 mL | 5.2521 mL | 13.1303 mL | |
10 mM | 0.2626 mL | 1.313 mL | 2.6261 mL | 6.5651 mL | |
20 mM | 0.1313 mL | 0.6565 mL | 1.313 mL | 3.2826 mL | |
50 mM | 0.0525 mL | 0.2626 mL | 0.5252 mL | 1.313 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TMN355 1186372-20-2 Others Inhibitor inhibit TMN-355 TMN 355 2-氯-N-[(9H-芴-9-氨基)羰基]-6-氟苯甲酰胺 inhibitor