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15

抑制剂 & 化合物

2

天然产物

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Cat. No. Product Name Target Signaling Pathways
T6713 Ulipristal

Estrogen/progestogen Receptor; Progesterone Receptor Endocrinology/Hormones; Others
Ulipristal 是性孕酮受体 (progesterone receptor) 的选择性调节剂。它能够与孕激素受体结合,抑制 PR 介导的基因表达,降低生殖系统中孕激素的活性。
T2527 Ulipristal acetate

Ulipristal,醋酸乌利司他,CDB-2914

Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy Autophagy; Endocrinology/Hormones; Others
Ulipristal acetate (CDB-2914) 是一种具有抗孕酮活性的选择性孕酮受体调节剂。它可抑制子宫平滑肌瘤病的生长。它通过抑制或延迟排卵和影响子宫内膜组织,可用作紧急避孕药。
T20720 Norethisterone enanthate

NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,炔诺酮庚酸酯,NSC-9564

Estrogen/progestogen Receptor Endocrinology/Hormones
Norethisterone enanthate (NSC-9564) 是一种口服有效的长效的孕激素。
T0384 Estradiol benzoate

Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin

Estrogen Receptor/ERR; Estrogen/progestogen Receptor Endocrinology/Hormones
Estradiol benzoate (Benzhormovarine) 是一种类固醇性激素,是一种雌二醇的前体药物。它表现出轻微的合成代谢特性,增加血液凝固性。
T20506 Maleuric acid

N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778

Others Others
Maleuric acid (N-Carbamoylmaleamic acid) 可抗有丝分裂,可与放射自显影技术结合起来用于生物研究。Maleuric acid 可用于改善动植物的生长和繁殖力以及治疗乳清酸缺乏症。
T2408 Ostarine

MK-2866,GTX-024,Enobosarm

Androgen Receptor Endocrinology/Hormones
Ostarine (MK-2866) 是一种具有合成代谢活性的非甾体药物。选择性雄激素受体调节剂 (SARM) GTx-024 旨在像睾酮一样发挥作用,从而促进和/或维持性欲、生育能力、前列腺生长以及肌肉生长和力量。模仿睾酮的作用,这种药物可以增加瘦体重,从而改善癌症恶病质高代谢状态下的肌肉萎缩。
T23737 Anordiol

H 241,H241,AF-45,AF 45,AF45

Anordiol is an antiestrogen with estrogenic activity. It also is known to inhibit fertility.
T33725 Norgestrienone

Planor,A-301,A301,Ogyline,A 301

Nogotrienone is an anabolic steroid with fertility and contraceptive activity that has been studied as a therapeutic agent for hereditary angioneurotic edema.
T24084 Gamendazole

Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.
T78515 Follicle-stimulating hormone

Others Others
卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白,其参与调控动物的生殖能力与繁殖效率。
T36916 Estrone-3-Glucuronide (sodium salt hydrate)

Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of fertility in women. 1.Blackwell, L.F., Brown, J.B., and Cooke, D.Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual ...
T77769 Menotropin

Human Menopausal Gonadotrophin

Menotropin (Human Menopausal Gonadotropin)为治疗生育障碍的激素活性药物,源自绝经后妇女的尿液提取。
T83428 1-Myristoyl-3-chloropropanediol

1-Myristoyl-3-chloropropanediol 是一种MCPD (3-一氯丙二醇) 脂肪酸酯。慢性口服该化合物可导致肾病、小管增生和腺瘤形成,在大鼠中也观察到生育能力下降,不育发生率增加,以及免疫功能受到抑制。
T35783 Zearalenone-13C18

Zearalenone-13C18

Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i...
T83870 BHD

BHD作为一种可逆的男性避孕化合物,在体内通过(100 和 500 mg/kg)剂量引发精子生成细胞凋亡和精子管异常,破坏血-睾丸屏障,降低雄性小鼠的生育指数,效果持续两至六周。

化合物

Ulipristal
Cat.No: T6713
Synonym:
Target: Estrogen/progestogen Receptor, Progesterone Receptor
Ulipristal acetate
Cat.No: T2527
Synonym: Ulipristal,醋酸乌利司他,CDB-2914
Target: Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy
Norethisterone enanthate
Cat.No: T20720
Synonym: NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,炔诺酮庚酸酯,NSC-9564
Target: Estrogen/progestogen Receptor
Estradiol benzoate
Cat.No: T0384
Synonym: Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Maleuric acid
Cat.No: T20506
Synonym: N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778
Target: Others
Ostarine
Cat.No: T2408
Synonym: MK-2866,GTX-024,Enobosarm
Target: Androgen Receptor
Anordiol
Cat.No: T23737
Synonym: H 241,H241,AF-45,AF 45,AF45
Target:
Norgestrienone
Cat.No: T33725
Synonym: Planor,A-301,A301,Ogyline,A 301
Target:
Gamendazole
Cat.No: T24084
Synonym:
Target:
Follicle-stimulating hormone
Cat.No: T78515
Synonym:
Target: Others
Estrone-3-Glucuronide (sodium salt hydrate)
Cat.No: T36916
Synonym:
Target:
Menotropin
Cat.No: T77769
Synonym: Human Menopausal Gonadotrophin
Target:
1-Myristoyl-3-chloropropanediol
Cat.No: T83428
Synonym:
Target:
Zearalenone-13C18
Cat.No: T35783
Synonym: Zearalenone-13C18
Target:
BHD
Cat.No: T83870
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T1048 Estradiol

雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Estradiol (E2) 是一种天然的类固醇性激素,对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。
TN2120 Quassin

Others; Antifection Microbiology/Virology; Others
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.

天然产物

Estradiol
Cat.No: T1048
Synonym: 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Quassin
Cat.No: TN2120
Synonym:
Target: Others, Antifection
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