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Search Results for " essential hypertension "

14

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6595	Moexipril hydrochloride 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。
T2621	Rostafuroxin PST 2238	ATPase; RSV	Membrane transporter/Ion channel; Microbiology/Virology
	Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物，是一种口服有效的 Na+,K+-ATPase 抑制剂，具有抗高血压和抗 RSV 活性，用于研究治疗原发性高血压的试验。
T6219	Azilsartan Medoxomil TAK-491,阿齐沙坦酯	RAAS	Endocrinology/Hormones
	Azilsartan Medoxomil (TAK-491) 是一种具有口服活性的1型血管紧张素II 受体拮抗剂(IC50:0.62 nM)。
T27119L	(Rac)-Daglutril SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid	Others	Others
	(Rac)-Daglutril (SLV 306 acetic acid) 是 Daglutril 的消旋体。Daglutril 是一种口服活性的混合中性内肽酶/内皮素转化酶抑制剂，正在开发用于治疗原发性高血压和充血性心力衰竭。
T70522	FK-906 HCl
	FK-906 HCl is a human renin inhibitor used for the long-term treatment of patients with essential hypertension.
T20167	Cilazapril Ro-34-2848,Ro 34-2848,Cilazapril (anhydrous),Ro34-2848,西拉普利
	Cilazapril is an angiotensin-converting enzyme inhibitor. It has been researched for mild to moderate essential hypertension.
T28323	PD 125754 PD125754,PD-125754
	PD 125754 is a Renin inhibitor, which represents a group of pharmaceutical drugs used primarily to treat essential hypertension.
T28324	PD 125967 PD125967,PD-125967
	PD 125967 is a renin inhibitor, which represents a group of pharmaceutical drugs used primarily to treat essential hypertension.
T27306	Fasidotril BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137
	Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in patients with essential hypertension.
T6340L	Enalaprilat MK422,MK 422,MK 421 diacid,Enalapril acid,MK-422
	Enalaprilat, the active metabolite of Enalapril, is a effective intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failur
T78567	Moprolol (±)-Moprolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Moprolol ((±)-Moprolol)为β-肾上腺素能受体阻滞剂，主要应用于原发性高血压研究。
T35871	Bopindolol (malonate)
	Bopindolol is a non-selective β-adrenergic receptor antagonist. In vivo, bopindolol decreases heart rate and blood pressure and attenuates ischemia-induced myocardial acidosis in dogs. Formulations containing bopindolol have been used to treat essential and renovascular hypertension.
T33673	Niludipine Niludipina,BAY-a 7168,Bay a 7168,Niludipinum
	Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug
T9451	Bopindolol
	Bopindolol 是一种口服活性的 β-肾上腺素受体 (ARs) 拮抗剂，具有部分激动剂活性。Bopindolol 对 β1- 和 β2-ARs 无选择性，对β3-AR 亚型亲和力低。Bopindolol 是 Pindolol 的前体药物，可迅速代谢为活性水解形式。Bopindolol 可用于原发性和肾血管性高血压的研究。

化合物

Moexipril hydrochloride

Cat.No: T6595

Synonym: 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

Cat.No: T2621

Synonym: PST 2238

Target: ATPase, RSV

Azilsartan Medoxomil

Cat.No: T6219

Synonym: TAK-491,阿齐沙坦酯

Target: RAAS

(Rac)-Daglutril

Cat.No: T27119L

Synonym: SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid

Target: Others

Cat.No: T70522

Cat.No: T20167

Synonym: Ro-34-2848,Ro 34-2848,Cilazapril (anhydrous),Ro34-2848,西拉普利

Cat.No: T28323

Synonym: PD125754,PD-125754

Cat.No: T28324

Synonym: PD125967,PD-125967

Cat.No: T27306

Synonym: BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137

Cat.No: T6340L

Synonym: MK422,MK 422,MK 421 diacid,Enalapril acid,MK-422

Cat.No: T78567

Synonym: (±)-Moprolol

Target: Adrenergic Receptor

Bopindolol (malonate)

Cat.No: T35871

Cat.No: T33673

Synonym: Niludipina,BAY-a 7168,Bay a 7168,Niludipinum

Cat.No: T9451

Cat. No.	Product Name	Target	Signaling Pathways
T17056	Tetrahydrobiopterin Sapropterin,BH4,(Rac)-Sapropterin	NOS; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子，可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。

天然产物

Tetrahydrobiopterin

Cat.No: T17056

Synonym: Sapropterin,BH4,(Rac)-Sapropterin

Target: NOS, Endogenous Metabolite

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